Piperazines

Carbosynth LLC. Biosynth Chemical Compound, 3-(2-Methoxyethyl)oxolan-3-amine hydrochloride

Biosynth Chemical Compound, 3-(2-Methoxyethyl)oxolan-3-amine hydrochloride

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Apexbio Technology LLC L-NIO dihydrochloride 159190-44-0 10mg

L-NIO dihydrochloride (CAS 159190-44-0) is a potent inhibitor of nitric oxide synthase (NOS) targeting inducible (iNOS) endothelial (eNOS) and neuronal (nNOS) isoforms with an IC50 of 65 M By blocking NOS activity L-NIO reduces nitric oxide (NO) production in activated macrophages and neutrophils which can influence both tumor cell cytotoxicity and inflammatory responses In vitro and in vivo studies demonstrate that L-NIO modulates vascular responses preventing immune complex-induced vasculitis and counteracting hypotensive effects triggered by acetylcholine and bradykinin This compound is widely utilized to investigate the role of NO in inflammation vascular regulation and immune-mediated tissue injury

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Apexbio Technology LLC CP 31398 dihydrochloride 1217195-61-3 10mg

CP 31398 dihydrochloride (CAS 1217195-61-3) is a small molecule that modulates the tumor suppressor protein p53 by stabilizing both wild-type and mutant forms thereby promoting p53-dependent transcriptional activity Through p53 pathway activation CP 31398 dihydrochloride increases p21 expression inhibits G1/S-phase cyclin-dependent kinase complexes and induces apoptosis in multiple cancer cell lines irrespective of p53 mutation status In various models including head and neck squamous cell carcinoma and colon adenocarcinoma it has demonstrated the ability to inhibit cancer cell proliferation and enhance the cytotoxic effects of chemotherapeutic agents Combined administration with celecoxib has been shown to significantly reduce both incidence and multiplicity of colon tumors in preclinical studies supporting its utility in cancer research and therapeutic strategy development

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Apexbio Technology LLC PI-103 Hydrochloride 371935-79-4 5mg

PI-103 Hydrochloride (CAS 371935-79-4) is a dual inhibitor targeting class I phosphatidylinositide 3-kinases (PI3K) and mammalian target of rapamycin (mTOR) It selectively inhibits PI3K isoforms p110 p110 p110 and mTOR with reported IC50 values of 0 002 M 0 003 M 0 003 M and 0 030 M respectively PI-103 effectively blocks the PI3K/Akt/mTOR pathway which is centrally involved in cell proliferation and survival signaling and is frequently dysregulated in cancer In various cellular models including leukemia hepatocellular carcinoma glioblastoma and neuroblastoma PI-103 suppresses pathway activation and inhibits cell proliferation It is widely used for investigating PI3K/Akt/mTOR signaling in oncology research

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Apexbio Technology LLC KX2-391 dihydrochloride 1038395-65-1 250mg

KX2-391 dihydrochloride (CAS 1038395-65-1) is an orally bioavailable small molecule that inhibits Src tyrosine kinase through selective interaction with the peptide substrate binding site rather than the ATP-binding site By blocking this non-catalytic domain KX2-391 disrupts Src kinase-mediated signaling pathways involved in tumor cell proliferation and metastatic processes Src kinases are frequently upregulated in various malignancies underscoring their importance in cancer biology KX2-391 is widely utilized in preclinical studies investigating Src-driven mechanisms of oncogenesis and tumor progression

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Medchemexpress LLC IT1t dihydrochloride | 1092776-63-0 | MFCD22683853 | 99.8% | 479.57 | C21H36Cl2N4S2 | 50 MG

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IT1t dihydrochloride is a potent small-molecule antagonist of the CXCR4 chemokine receptor. It inhibits CXCL12/CXCR4 interaction with high potency (IC50 ≈ 2.1 nM), shows activity in HIV-1 (X4) cellular assays, and has been used in preclinical metastasis models. Supplied as the dihydrochloride salt for research use.

• Potent CXCR4 antagonist with low-nanomolar potency.
• Active in HIV-1 (X4) cellular assays.
• Suitable for CXCR4 signaling and metastasis studies.
• Provided as a dihydrochloride salt for stability.
• High reported purity (≈99.8%).
• Available in small research pack sizes (mg scale).

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eMolecules​ 110-85-0 | Piperazine | Chem-Impex | MFCD00005953 | 86.138 | C4H10N2 | 99.000 | C1CNCCN1 | 5kg | 272385526

Piperazine | Chem-Impex | 110-85-0 | MFCD00005953 | 86.138 | C4H10N2 | 99.000 | C1CNCCN1 | 5kg | 272385526

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Apexbio Technology LLC GW 583340 dihydrochloride 50mg

GW 583340 dihydrochloride (CAS 1173023-85-2) is a small molecule inhibitor targeting the tyrosine kinase activity of both EGFR and ErbB2 exhibiting potent inhibitory effects with IC50 values of 0 01 M and 0 014 M respectively In addition to suppressing these receptor-mediated signaling pathways GW 583340 dihydrochloride has been shown to inhibit ABC transporters including ABCG2 and ABCB1 thereby reversing transporter-associated multidrug resistance This compound is utilized in tumor biology research to investigate the modulation of oncogenic signaling mechanisms underlying drug resistance and to explore potential therapeutic strategies

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Apexbio Technology LLC CGH 2466 dihydrochloride 1177618-54-0 10mg

CGH 2466 dihydrochloride is a small-molecule antagonist targeting adenosine receptors with inhibitory activities against phosphodiesterase type 4 (PDE4) and p38 mitogen-activated protein kinase (MAPK) It is designed to block adenosine receptor signaling and inhibit key inflammatory enzymes thereby modulating inflammatory pathways CGH 2466 dihydrochloride exerts its biological activity primarily through selective inhibition of the PDE4D isoform (IC50 22 5 nM) and inhibition of p38 MAPK and isoforms (IC50 187 18 nM and 400 38 nM respectively) It shows comparable affinities to CGS15943 for the adenosine A1 A2B and A3 receptors but no activity at the A2A receptor Based on these pharmacological properties CGH 2466 dihydrochloride holds research potential in studies involving inflammatory mechanisms such as allergen-induced eosinophilic airway inflammation models

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Medchemexpress LLC PENTOXYVERINE CITRA 5G

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PENTOXYVERINE CITRA 5G

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Medchemexpress LLC ACEPROMAZINE-1-PIPER 10 mg

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ACEPROMAZINE-1-PIPER 10MG

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Medchemexpress LLC ACEPROMAZINE-1-PIPER 100 mg

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ACEPROMAZINE-1-PIPER 100MG

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Medchemexpress LLC ACEPROMAZINE-1-PIPER 50 mg

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ACEPROMAZINE-1-PIPER 50MG

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Medchemexpress LLC ACEPROMAZINE-1-PIPER 5 mg

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ACEPROMAZINE-1-PIPER 5MG

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Aobchem 4-Bromo-1-(2-methoxyethyl)-3 5-dimethyl-1H-pyrazole | ≥97% | CAS 1342761-60-7 | C8H13BrN2O | 250mg

4-Bromo-1-(2-methoxyethyl)-3 5-dimethyl-1H-pyrazole | ≥97% | CAS 1342761-60-7 | C8H13BrN2O | 250mg

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