Piperazines
Selleck Chemical LLC AZ10606120 dihydrochloride S3520-5mg
AZ10606120 dihydrochloride (2HCl) is a potent and selective antagonist for P2X7 receptor (P2X7R) with IC50 of 10 nM AZ10606120 dihydrochloride exhibits anti-depressant effects and reduces tumour growth This product is not soluble in PBS solution Please do not dissolve it in PBS for administration
Apexbio Technology LLC Copanlisib dihydrochloride 1402152-13-9 5mg
Copanlisib dihydrochloride (CAS 1402152-13-9) is a small-molecule inhibitor that selectively targets phosphoinositide 3-kinase (PI3K) isoforms and By inhibiting these PI3K subunits copanlisib disrupts PI3K/AKT signaling pathways that regulate cellular proliferation and survival leading to reduced tumor cell growth and induction of apoptosis This compound is utilized in biomedical research to investigate PI3K-mediated oncogenic processes particularly in studies related to relapsed or refractory follicular lymphoma and other hematologic malignancies dependent on aberrant PI3K activity
Medchemexpress LLC 3'-O-(2-Methoxyethyl)guanosine | 256224-03-0 | C13H19N5O6 | 250 MG
3'-O-(2-Methoxyethyl)guanosine is a guanosine analogue. It exhibits immunostimulatory activity, and in some animal models, it induces type I interferons, leading to antiviral effects. Its functional activity is dependent on the activation of Toll-like receptor 7 (TLR7).
- Guanosine analogue
- Immunostimulatory activity
- Induces type I interferons
- Produces antiviral effects
- Functional activity dependent on activation of Toll-like receptor 7 (TLR7)
Apexbio Technology LLC AY 9944 dihydrochloride(Synonyms: AY-9944, AY9944, AY 9944, trans-1,4-Bis(2-chlorobenzylaminomethyl)cyclohexane dihydrochloride), 10mg, CAS: 366-93-8.
AY 9944 dihydrochloride (CAS 366-93-8) is a selective inhibitor of 7-sterol reductase (Dhcr7) an enzyme involved in cholesterol biosynthesis through NADPH-dependent conversion of 7-dehydrocholesterol to cholesterol AY 9944 dihydrochloride inhibits recombinant human 7-sterol reductase expressed in yeast cells with an IC50 of 13 nM In an SD rat model of Smith-Lemli-Opitz syndrome AY 9944 treatment leads to increased accumulation of 7-dehydrocholesterol and decreased cholesterol levels across various tissues Additionally in PBMCs isolated from AIDS patients AY 9944 intervention restored mitogenic responses and cytokine production suggesting research applications in immunological studies and cholesterol metabolism disorders
Apexbio Technology LLC AY 9944 dihydrochloride(Synonyms: AY-9944, AY9944, AY 9944, trans-1,4-Bis(2-chlorobenzylaminomethyl)cyclohexane dihydrochloride), 5mg, CAS: 366-93-8.
AY 9944 dihydrochloride (CAS 366-93-8) is a selective inhibitor of 7-sterol reductase (Dhcr7) an enzyme involved in cholesterol biosynthesis through NADPH-dependent conversion of 7-dehydrocholesterol to cholesterol AY 9944 dihydrochloride inhibits recombinant human 7-sterol reductase expressed in yeast cells with an IC50 of 13 nM In an SD rat model of Smith-Lemli-Opitz syndrome AY 9944 treatment leads to increased accumulation of 7-dehydrocholesterol and decreased cholesterol levels across various tissues Additionally in PBMCs isolated from AIDS patients AY 9944 intervention restored mitogenic responses and cytokine production suggesting research applications in immunological studies and cholesterol metabolism disorders
Apexbio Technology LLC AY 9944 dihydrochloride(Synonyms: AY-9944, AY9944, AY 9944, trans-1,4-Bis(2-chlorobenzylaminomethyl)cyclohexane dihydrochloride), 25mg, CAS: 366-93-8.
AY 9944 dihydrochloride (CAS 366-93-8) is a selective inhibitor of 7-sterol reductase (Dhcr7) an enzyme involved in cholesterol biosynthesis through NADPH-dependent conversion of 7-dehydrocholesterol to cholesterol AY 9944 dihydrochloride inhibits recombinant human 7-sterol reductase expressed in yeast cells with an IC50 of 13 nM In an SD rat model of Smith-Lemli-Opitz syndrome AY 9944 treatment leads to increased accumulation of 7-dehydrocholesterol and decreased cholesterol levels across various tissues Additionally in PBMCs isolated from AIDS patients AY 9944 intervention restored mitogenic responses and cytokine production suggesting research applications in immunological studies and cholesterol metabolism disorders
Medchemexpress LLC 7-chloro-4-(piperazin-1-yl)quinoline | 837-52-5 | MFCD01476123 | 98.6% | 247.72 g/mol | C13H14ClN3 | 250 MG
7-Chloro-4-(piperazin-1-yl)quinoline is a small-molecule quinoline scaffold bearing a piperazine substituent, used as a building block and research reagent in medicinal chemistry, screening, and assay development. It is supplied as a solid and as DMSO solutions and is provided at high purity for analytical and biological studies.
- High purity (98.6%) suitable for research applications.
- Available in multiple pack sizes, including 25 mg-1 g and 10 mM DMSO solutions.
- Supplied as solid and as DMSO solution for screening workflows.
- Molecular formula C13H14ClN3; molecular weight 247.72 g/mol.
- Useful scaffold for medicinal chemistry and lead optimization.
Apexbio Technology LLC AO/PI Staining Solution 250T
AO/PI Staining Solution contains two DNA fluorescent dyes Acridine Orange (AO) and Propidium Iodide (PI) AO is able to cross intact cell membranes and label nuclei in all cells (both live and dead) emitting green fluorescence In contrast PI can penetrate only compromised cell membranes thus staining exclusively the nuclei of dead cells emitting red fluorescence This staining solution is optimized for use with fluorescence-based cell counters to accurately count cells Traditional Trypan Blue staining has low specificity often leading to inaccurate counting results due to the inclusion of cell debris or residual red blood cells in PMBC samples Since AO and PI are DNA-specific dyes their use effectively eliminates interference from impurities and red blood cells enabling precise and accurate cell counting
Apexbio Technology LLC AO/PI Staining Solution 1250T
AO/PI Staining Solution contains two DNA fluorescent dyes Acridine Orange (AO) and Propidium Iodide (PI) AO is able to cross intact cell membranes and label nuclei in all cells (both live and dead) emitting green fluorescence In contrast PI can penetrate only compromised cell membranes thus staining exclusively the nuclei of dead cells emitting red fluorescence This staining solution is optimized for use with fluorescence-based cell counters to accurately count cells Traditional Trypan Blue staining has low specificity often leading to inaccurate counting results due to the inclusion of cell debris or residual red blood cells in PMBC samples Since AO and PI are DNA-specific dyes their use effectively eliminates interference from impurities and red blood cells enabling precise and accurate cell counting