Piperazinoazepines
Medchemexpress LLC Mirtazapine | 85650-52-8 | MFCD00865427 | 99.9% | 25 MG
Mirtazapine is a potent and orally active noradrenergic and specific serotonergic antidepressant (NaSSA) agent. It acts as an antagonist for 5-HT2, 5-HT3, histamine H1 receptors, and α2-adrenoceptors. This compound is intended for research use only and is not sold to patients.
- Potent and orally active NaSSA agent
- Antagonist of multiple receptors: 5-HT2, 5-HT3, histamine H1 receptor, and α2-adrenoceptor
- Enhances norepinephrine and 5-HT1A-mediated serotonergic transmission
- Inhibits hepatic macrophage/monocyte activation, decreases pro-inflammatory cytokine and chemokine production, and suppresses ICAM-1 expression, leading to reduced neutrophil recruitment into the liver (observed in mice)
- Metabolized by CYP1A2, CYP2D6, and CYP3A4 isoenzymes
- Significantly reduces activation-induced release of cytokine/chemokine mediators from human CD14+ monocytes in vitro
Apexbio Technology LLC Mirtazapine 85650-52-8 50mg
Mirtazapine is a small-molecule antagonist targeting central presynaptic 2-adrenergic receptors as well as serotonin 5-HT2 and 5-HT3 receptors and central histamine H1 receptors It is designed to modulate monoaminergic neurotransmission thereby affecting mood regulation pathways Mirtazapine exerts its biological activity primarily through selective antagonism of central presynaptic 2-adrenergic receptors inducing increased synaptic release of norepinephrine and serotonin It also antagonizes serotonin 5-HT2 and 5-HT3 receptors Based on these pharmacological properties mirtazapine holds research potential in the fields of neuroscience and psychopharmacology particularly for studies involving depressive disorders anxiety conditions and mood regulation
Medchemexpress LLC Mirtazapine-d3 | 1216678-68-0 | M002686 | 99.68% | 5 MG
Mirtazapine-d3 is a deuterium-labeled Mirtazapine. Mirtazapine is a 5-HT receptor inhibitor, and a potent, orally active noradrenergic and specific serotonergic antidepressant (NaSSA) that works by blocking 5-HT2 and 5-HT3 receptors.
- Used as a tracer
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Potent, orally active noradrenergic and specific serotonergic antidepressant (NaSSA)
- Blocks 5-HT2 and 5-HT3 receptors
- Deuterium-labeled compound
eMolecules 85650-52-8 | Medchem Express | Mirtazapine | 100mg | 446272559 | HY-B0352 | MFCD00865427 | 265.36 | C17H19N3
Medchem Express | Mirtazapine | 100mg | 446272559 | HY-B0352 | 85650-52-8 | MFCD00865427 | 265.360 | C17H19N3
Medchemexpress LLC Mirtazapine | 85650-52-8 | 99.9% | 500 MG
Mirtazapine (Org3770) is a potent and orally active noradrenergic and specific serotonergic antidepressant (NaSSA) agent. It functions as a 5-HT2, 5-HT3, histamine H1 receptor, and α2-adrenoceptor antagonist, influencing norepinephrine and 5-HT1A-mediated serotonergic transmission. It is primarily metabolized by CYP1A2, CYP2D6, and CYP3A4.
- Potent and orally active antidepressant
- Acts as a 5-HT2, 5-HT3, histamine H1 receptor, and α2-adrenoceptor antagonist
- Enhances release of norepinephrine
- Enhances 5-HT1A-mediated serotonergic transmission
- Reduces activation-induced release of cytokine/chemo kine mediators from human CD14+ monocytes in vitro
- Inhibits Con A-induced liver injury in vivo by suppressing hepatic macrophage/monocyte activation and pro-inflammatory cytokine production
Medchemexpress LLC (R)-Mirtazapine ((R)-Org3770) | 61364-37-2 | 99.8%
(R)-Mirtazapine is an R(+)-enantiomer of Mirtazapine with antinociceptive properties. It functions as a 5-HT3 receptor antagonist and is primarily metabolized by CYP3A4.
- Acts as a 5-HT3 receptor antagonist
- Primarily metabolized by CYP3A4
- Exhibits antinociceptive properties
- Suitable for research use only
Medchemexpress LLC Pyrazino[2,1-a]pyrido[2,3-c]benzazepine, 1,2,3,4,10,14b-hexahydro-2-methyl-, (14bS)- | 61337-87-9 | 99.8% | 25 MG
(S)-Mirtazapine ((S)-Org3770) is an S(+)-enantiomer of Mirtazapine. It exhibits pronociceptive properties in an animal model of acute thermal nociception and acts as a stereoselective 5-HT2 receptor antagonist. It is metabolized by CYP2D6 and CYP1A2. The product is intended for research use only and is not sold to patients.
- S(+)-enantiomer of mirtazapine
- Exhibits pronociceptive properties in an animal model
- Acts as a stereoselective 5-HT2 receptor antagonist
- Metabolized by CYP2D6 and CYP1A2
- Purity: 99.8%
- Enantiomeric excess: 98.35%
- Molecular weight: 265.35
- Molecular formula: C17H19N3
- Appearance: Solid, off-white to light yellow
- Solubility in DMSO: ≥ 100 mg/mL
- Intended for research use only
Medchemexpress LLC Mirtazapine | 85650-52-8 | 99.9% | 5 MG
Mirtazapine is a potent and orally active noradrenergic and specific serotonergic antidepressant (NaSSA) agent. It functions as a 5-HT2, 5-HT3, histamine H1 receptor, and α2-adrenoceptor antagonist.
- Antagonizes adrenergic α2-autoreceptors and α2-heteroreceptors
- Blocks 5-HT2 and 5-HT3 receptors
- Enhances norepinephrine release and 5-HT1A-mediated serotonergic transmission
- Metabolized by cytochrome P450 isoenzymes CYP1A2, CYP2D6, and CYP3A4
- Reduces activation-induced release of cytokine/chemokine mediators from human CD14+ monocytes
- Inhibits Con A-induced liver injury
eMolecules 61337-87-9 | Medchem Express | (S)-Mirtazapine | 5mg | 761506639 | HY-B0352A | 265.36 | C17H19N3
Medchem Express | (S)-Mirtazapine | 5mg | 761506639 | HY-B0352A | 61337-87-9 | 265.360 | C17H19N3
Medchemexpress LLC Mianserin | 24219-97-4 | 99.4% | 50 MG
Mianserin is an orally active H1 receptor antagonist that can activate κ-opioid and octopamine receptors. It increases ERK1/2 and CREB phosphorylation, and antagonizes full κ-opioid agonist and Dynorphin A-induced MAPK phosphorylation. It modulates social and exploratory behavior and raises electroconvulsive thresholds. Mianserin is used for research of neurological diseases such as depression and epilepsy.
- Orally active H1 receptor antagonist
- Activates κ-opioid receptor
- Activates octopamine receptor
- Increases ERK1/2 and CREB phosphorylation
- Antagonizes full κ-opioid agonist and Dynorphin A-induced MAPK phosphorylation
- Modulates social and exploratory behavior
- Raises electroconvulsive thresholds
- Useful for research of neurological diseases like depression and epilepsy
Medchemexpress LLC Mianserin | 24219-97-4 | 99.4% | 5 MG
Mianserin (Mianserine) is an orally active H1 receptor antagonist. It can activate κ-opioid receptors and octopamine receptors. Mianserin increases ERK1/2 and CREB phosphorylation and antagonizes full κ-opioid agonist and Dynorphin A-induced MAPK phosphorylation. It modulates social and exploratory behavior and raises electroconvulsive thresholds. It is used in research for neurological diseases such as depression and epilepsy.
- Orally active H1 receptor antagonist
- Activates κ-opioid and octopamine receptors
- Increases ERK1/2 and CREB phosphorylation
- Modulates social and exploratory behavior
- Raises electroconvulsive thresholds
- Used in research for neurological diseases such as depression and epilepsy
Medchemexpress LLC Mirtazapine | 85650-52-8 | MFCD00865427 | 99.95% | 100 MG
Mirtazapine (Standard) is the analytical standard of Mirtazapine, intended for research and analytical applications. It is a potent and orally active noradrenergic and specific serotonergic antidepressant (NaSSA) agent. Mirtazapine is also a 5-HT2, 5-HT3, histamine H1 receptor, and α2-adrenoceptor antagonist with pKi values of 8.05, 8.1, 9.3, and 6.95, respectively.
- Analytical standard for research and analytical applications
- Potent and orally active noradrenergic and specific serotonergic antidepressant (NaSSA) agent
- 5-HT2, 5-HT3, histamine H1 receptor, and α2-adrenoceptor antagonist
- Used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS