Piperazinoazepines
Medchemexpress LLC R-mirtazapine | 61364-37-2 | 99.8% | 265.35 g·mol⁻¹ | C17H19N3 | 10 MG
(R)-Mirtazapine is the R-enantiomer of mirtazapine, described as a 5-HT3 receptor antagonist with reported antinociceptive activity. It is supplied as a high-purity solid research reagent intended for laboratory use.
- High purity: 99.8%.
- Chiral R-enantiomer with 5-HT3 receptor antagonist activity.
- Chemical formula C17H19N3; molecular weight 265.35 g·mol⁻¹.
- CAS number 61364-37-2 for substance identification.
- Supplied as a solid powder suitable for analytical and preclinical research.
- Storage: powder at -20°C (3 years) or 4°C (2 years); in solvent at -80°C (6 months).
Medchemexpress LLC (S)-Mirtazapine | 61337-87-9 | 99.8% | 5 MG
(S)-Mirtazapine ((S)-Org3770) is an S(+)-enantiomer of Mirtazapine, exhibiting pronociceptive properties within an animal model of acute thermal nociception. It functions as a stereoselective 5-HT2 receptor antagonist and undergoes metabolism by CYP2D6 and CYP1A2.
- It is an S(+)-enantiomer of Mirtazapine.
- It has pronociceptive properties in an animal model of acute thermal nociception.
- It is a stereoselective 5-HT2 receptor antagonist.
- It is metabolized by CYP2D6 and CYP1A2.
- The molecular weight is 265.35.
- The chemical formula is C17H19N3.
- It appears as a solid.
- The color ranges from off-white to light yellow.
- The purity is 99.76%.
- The enantiomeric excess is 98.35%.
Medchemexpress LLC Mirtazapine | 85650-52-8 | 99.9% | 5 MG
Mirtazapine is a potent and orally active noradrenergic and specific serotonergic antidepressant (NaSSA) agent. It functions as a 5-HT2, 5-HT3, histamine H1 receptor, and α2-adrenoceptor antagonist.
- Antagonizes adrenergic α2-autoreceptors and α2-heteroreceptors
- Blocks 5-HT2 and 5-HT3 receptors
- Enhances norepinephrine release and 5-HT1A-mediated serotonergic transmission
- Metabolized by cytochrome P450 isoenzymes CYP1A2, CYP2D6, and CYP3A4
- Reduces activation-induced release of cytokine/chemokine mediators from human CD14+ monocytes
- Inhibits Con A-induced liver injury
Medchemexpress LLC Mianserin | 24219-97-4 | 99.4% | 5 MG
Mianserin (Mianserine) is an orally active H1 receptor antagonist. It can activate κ-opioid receptors and octopamine receptors. Mianserin increases ERK1/2 and CREB phosphorylation and antagonizes full κ-opioid agonist and Dynorphin A-induced MAPK phosphorylation. It modulates social and exploratory behavior and raises electroconvulsive thresholds. It is used in research for neurological diseases such as depression and epilepsy.
- Orally active H1 receptor antagonist
- Activates κ-opioid and octopamine receptors
- Increases ERK1/2 and CREB phosphorylation
- Modulates social and exploratory behavior
- Raises electroconvulsive thresholds
- Used in research for neurological diseases such as depression and epilepsy
Medchemexpress LLC Mirtazapine (Standard) | 85650-52-8 | 99.9% | 5 MG
Mirtazapine (Standard) is the analytical standard of Mirtazapine, intended for research and analytical applications. This potent, orally active noradrenergic and specific serotonergic antidepressant (NaSSA) agent also functions as a 5-HT2, 5-HT3, histamine H1 receptor, and α2-adrenoceptor antagonist. It is commonly used in qualitative, quantitative, and methodological research experiments, including HPLC, GC, and MS.
- Analytical standard for Mirtazapine
- Potent and orally active noradrenergic and specific serotonergic antidepressant (NaSSA)
- Functions as a 5-HT2, 5-HT3, histamine H1 receptor, and α2-adrenoceptor antagonist
- Suitable for research and analytical applications
- Used in HPLC, GC, and MS experiments
- High purity of 99.95%
- White to off-white solid appearance
- Molecular weight of 265.36 and formula C₁₇H₁₉N₃
Medchemexpress LLC Mianserin hydrochloride | 21535-47-7 | 99.95% | 1 ML
Mianserin hydrochloride is an orally active H1 receptor antagonist that can also activate κ-opioid and octapamine receptors. It increases ERK1/2 and CREB phosphorylation, and antagonizes full κ-opioid agonist and dynorphin A-induced MAPK phosphorylation. This compound modulates social and exploratory behavior, raises electroconvulsive thresholds, and is used in research for neurological diseases like depression and epilepsy.
- Orally active H1 receptor antagonist
- Activates κ-opioid receptor and octopamine receptor
- Increases ERK1/2 and CREB phosphorylation
- Antagonizes κ-opioid agonist and dynorphin A-induced MAPK phosphorylation
- Modulates social and exploratory behavior
- Raises electroconvulsive thresholds
- Used for research of neurological diseases, including depression and epilepsy
Medchemexpress LLC Mirtazapine | 85650-52-8 | MFCD00865427 | 99.95% | 100 MG
Mirtazapine (Standard) is the analytical standard of Mirtazapine, intended for research and analytical applications. It is a potent and orally active noradrenergic and specific serotonergic antidepressant (NaSSA) agent. Mirtazapine is also a 5-HT2, 5-HT3, histamine H1 receptor, and α2-adrenoceptor antagonist with pKi values of 8.05, 8.1, 9.3, and 6.95, respectively.
- Analytical standard for research and analytical applications
- Potent and orally active noradrenergic and specific serotonergic antidepressant (NaSSA) agent
- 5-HT2, 5-HT3, histamine H1 receptor, and α2-adrenoceptor antagonist
- Used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS
Medchemexpress LLC Mianserin | 24219-97-4 | 99.4% | 50 MG
Mianserin is an orally active H1 receptor antagonist that can activate κ-opioid and octopamine receptors. It increases ERK1/2 and CREB phosphorylation, and antagonizes full κ-opioid agonist and Dynorphin A-induced MAPK phosphorylation. It modulates social and exploratory behavior and raises electroconvulsive thresholds. Mianserin is used for research of neurological diseases such as depression and epilepsy.
- Orally active H1 receptor antagonist
- Activates κ-opioid receptor
- Activates octopamine receptor
- Increases ERK1/2 and CREB phosphorylation
- Antagonizes full κ-opioid agonist and Dynorphin A-induced MAPK phosphorylation
- Modulates social and exploratory behavior
- Raises electroconvulsive thresholds
- Useful for research of neurological diseases like depression and epilepsy