Piperidines
Medchemexpress LLC (S,R)-GSK321 | 1816272-18-0 | 98.6% | 100 MG
(S,R)-GSK321 is the (S,R)-enantiomer of GSK321. It is a potent, selective mutant IDH1 inhibitor with IC50 values for R132G, R132C, R132H, and WT IDH1, and exhibits >100-fold selectivity over IDH2. (S,R)-GSK321 induces a decrease in intracellular 2-HG, abrogation of the myeloid differentiation block, and induction of granulocytic differentiation. It can be used for research of acute myeloid leukemia (AML) and other cancers.
- Potent, selective mutant IDH1 inhibitor
- Induces a decrease in intracellular 2-HG
- Abrogation of myeloid differentiation block
- Induction of granulocytic differentiation
- Useful in research for acute myeloid leukemia (AML) and other cancers
- Store powder at -20°C for 3 years or 4°C for 2 years
- Store in solvent at -80°C for 6 months or -20°C for 1 month
Medchemexpress LLC Donepezil-d4 hydrochloride (E2020-d4) | 1219798-88-5 | 99.96% | C24H26D4ClNO3 | 1 MG
Donepezil-d4 (hydrochloride) is the deuterium labeled Donepezil hydrochloride. Donepezil Hydrochloride (E2020) is a reversible, selective AChE inhibitor with an IC50 of 6.7 nM for AChE activity. Donepezil shows high selectivity for AChE over BuChE and exhibits neuroprotective effect on Aβ42 neurotoxicity.
- Acts as a reversible, selective AChE inhibitor.
- Demonstrates high selectivity for AChE over BuChE.
- Shows neuroprotective effects against Aβ42 neurotoxicity.
- Can be utilized as a tracer in research.
- Serves as an internal standard for quantitative analysis using techniques such as NMR, GC-MS, or LC-MS.
- Stable heavy isotopes can influence pharmacokinetic and metabolic profiles of drugs.
eMolecules 117896-69-2 | 1-PHENYL-4-PIPERIDINOL | MFCD02093533 | 1g
Ambeed | Methyl 6-methylbenzo[d]thiazole-2-carboxylate | 100mg | 596569208 | A726755 | 1236115-18-6 | MFCD22373213 | 207.250 | C10H9NO2S
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eMolecules 85275-45-2 | tert-Butyl 3-hydroxypiperidine-1-carboxylate | Ambeed | MFCD02093938 | 201.266 | C10H19NO3 | 98.000 | CC(C)(C)OC(=O)N1CCCC(O)C1 | 25g | 490511990
tert-Butyl 3-hydroxypiperidine-1-carboxylate | Ambeed | 85275-45-2 | MFCD02093938 | 201.266 | C10H19NO3 | 98.000 | CC(C)(C)OC(=O)N1CCCC(O)C1 | 25g | 490511990
Medchemexpress LLC (R,R)-GSK321 | 1816272-19-1 | 99.4% | 10 MG
(R,R)-GSK321 is an inhibitor of wild-type isocitrate dehydrogenase 1 (WT IDH1) with an IC50 value of 120 nM. This compound also acts as a mutant R132H IDH1 inhibitor and is an isomer of GSK321 with some wild-type cross-reactivity. It has a molecular weight of 501.55 and a chemical formula of C28H28FN5O3. This product appears as a white to off-white solid.
- Inhibits wild-type isocitrate dehydrogenase 1 (WT IDH1)
- IC50 value of 120 nM for WT IDH1
- Acts as a mutant R132H IDH1 inhibitor
- Isomer of GSK321 with some wild-type cross-reactivity
- Dose-dependently decreases reductive glutaminolysis in A-498 cells (0.1-3 μM for 5 hours)
- For research use only, not for patient use
Medchemexpress LLC (R,R)-GSK321 | 1816272-19-1 | 99.4% | 50 MG
(R,R)-GSK321 is a potent inhibitor of wild-type isocitrate dehydrogenase 1 (WT IDH1) with an IC50 value of 120 nM. This compound also acts as a mutant R132H IDH1 inhibitor, being an isomer of GSK321 with some wild-type cross-reactivity.
- Potent WT IDH1 inhibitor
- IC50 value of 120 nM for WT IDH1
- Mutant R132H IDH1 inhibitor
- Decreases reductive glutaminolysis in A-498 cells
- For research use only
- Associated with cancer, cancer targeted therapy, and cancer metabolism research
- Classified as a metabolic enzyme/protease and isocitrate dehydrogenase (IDH) inhibitor
eMolecules 5382-16-1 | 4-Piperidinol | J & W PharmLab, LLC | MFCD00005999 | 101.149 | C5H11NO | 96.000 | OC1CCNCC1 | 100g | 250013253
4-Piperidinol | J & W PharmLab, LLC | 5382-16-1 | MFCD00005999 | 101.149 | C5H11NO | 96.000 | OC1CCNCC1 | 100g | 250013253
eMolecules 1355326-21-4 | Medchem Express | Mutant IDH1-IN-1 | 5mg | 446261328 | HY-12475 | MFCD28385853 | 498.602 | C30H31FN4O2
ChemScene | Azido-PEG2-C2-amine | 100mg | 665615397 | CS-0114352 | 166388-57-4 | MFCD13189985 | 174.204 | C6H14N4O2
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Medchemexpress LLC (S,R)-GSK321 | 1816272-18-0 | 98.6% | 10 MG
(S,R)-GSK321 is a potent and selective mutant IDH1 inhibitor, specifically the (S,R)-enantiomer of GSK321. It demonstrates high selectivity over IDH2 and induces a decrease in intracellular 2-HG. This compound abrogates the myeloid differentiation block and promotes granulocytic differentiation in leukemic blasts and immature stem-like cells. It is suitable for research into acute myeloid leukemia (AML) and other cancers.
- Potent, selective mutant IDH1 inhibitor
- IC50 values of 2.9, 3.8, 4.6 and 46 nM for R132G, R132C, R132H and WT IDH1, respectively
- Greater than 100-fold selectivity over IDH2
- Induces a decrease in intracellular 2-HG
- Abrogates the myeloid differentiation block
- Induces granulocytic differentiation in leukemic blasts and immature stem-like cells
- Used for research of acute myeloid leukemia (AML) and other cancers
eMolecules 34737-89-8 | 1-Benzyl-3-methyl-piperidin-4-one | J & W PharmLab, LLC | MFCD00044806 | 203.285 | C13H17NO | 96.000 | CC1CN(Cc2ccccc2)CCC1=O | 25g | 250013340
1-Benzyl-3-methyl-piperidin-4-one | J & W PharmLab, LLC | 34737-89-8 | MFCD00044806 | 203.285 | C13H17NO | 96.000 | CC1CN(Cc2ccccc2)CCC1=O | 25g | 250013340
eMolecules 1628317-18-9 | Medchem Express | MI-463 | 1mg | 446270394 | HY-19809 | MFCD28506301 | 484.55 | C24H23F3N6S
Ambeed | (3aR3aR8aS8aS)-22-(Cyclopropane-11-diyl)bis(88a-dihydro-3aH-indeno[12-d]oxazole) | 100mg | 539141856 | A1165102 | 229184-98-9 | 356.425 | C23H20N2O2
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Matrix Scientific 1-BENZYLPIPERIDIN-3-ONE HYD-5G
1-Benzylpiperidin-3-one hydrochloride, 5g,C12H16ClNO, MFCD00012791, mw 225.72, [40114-49-6]
eMolecules 1186663-32-0 | 4-Fluoro-4-piperidinecarboxylic Acid Hydrochloride | MFCD12198891 | 1g
ChemScene | 2-Fluoro-6-(4455-tetramethyl-132-dioxaborolan-2-yl)benzaldehyde | 100mg | 714102368 | CS-0020236 | 1246633-35-1 | MFCD18383508 | 250.080 | C13H16BFO3
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eMolecules 4783-65-7 | 1-Benzylpiperidin-2-one | Oakwood Chemicals | MFCD00464162 | 189.258 | C12H15NO | 98.000 | O=C1CCCCN1Cc1ccccc1 | 1g | 480163888
1-Benzylpiperidin-2-one | Oakwood Chemicals | 4783-65-7 | MFCD00464162 | 189.258 | C12H15NO | 98.000 | O=C1CCCCN1Cc1ccccc1 | 1g | 480163888