Piperidines
Apexbio Technology LLC CHIR-124 405168-58-3 5mg
CHIR-124 (CAS 405168-58-3) is a selective small-molecule inhibitor of checkpoint kinase 1 (Chk1) with an IC50 of 0 3 nM demonstrating over 2 000-fold selectivity versus Chk2 (IC50 0 7 M) It also inhibits PDGFR and FLT3 with nanomolar potency CHIR-124 abrogates DNA damage-induced S and G2-M cell cycle checkpoints and enhances mitotic cell death particularly in p53-deficient tumor cells In preclinical studies CHIR-124 potentiates the cytotoxicity of topoisomerase I poisons such as camptothecin and irinotecan and increases radiosensitivity in various p53-mutant human tumor models This compound is widely used to investigate DNA damage response mechanisms and potential combination strategies in cancer therapy research
Medchemexpress LLC K-Ras-PDE -IN-1 25mg | 1841464-21-8 | 447.50 g/mol | C25H26FN5O2 | 25 MG
K-Ras-PDEδ-IN-1 is a small-molecule research compound that competitively inhibits PDEδ by binding the farnesyl-binding pocket with low nanomolar affinity (Kd ≈ 8 nM). It is supplied as a solid for in vitro and in vivo research applications and includes solubility and formulation guidance for biomedical studies.
- Potent competitive inhibitor of PDEδ with Kd ≈ 8 nM.
- Intended for use in Ras/PDEδ biological research in vitro and in vivo.
- Soluble in DMSO at about 12.5 mg/mL; in vivo suspension guidance at ~1.25 mg/mL with standard vehicle.
- Molecular formula C25H26FN5O2 and molecular weight 447.50 g/mol.
- Supplied as a solid powder suitable for biochemical and cellular assays.
eMolecules 90485-53-3 | 5-Amino-1-methylpiperidin-2-one | Combi-Blocks | MFCD09971184 | 128.175 | C6H12N2O | 95.000 | CN1CC(N)CCC1=O | 1g | 232323932
5-Amino-1-methylpiperidin-2-one | Combi-Blocks | 90485-53-3 | MFCD09971184 | 128.175 | C6H12N2O | 95.000 | CN1CC(N)CCC1=O | 1g | 232323932
Apexbio Technology LLC Amodiaquine dihydrochloride dihydrate 6398-98-7 500mg
Amodiaquine dihydrochloride dihydrate (CAS 6398-98-7) is a small-molecule inhibitor targeting histamine N-methyltransferase (HNMT) It is designed to inhibit HNMT thereby affecting intracellular histamine metabolism Amodiaquine dihydrochloride dihydrate exerts its biological activity primarily through inhibition of HNMT In biochemical assays involving rat kidney-derived HNMT amodiaquine demonstrates inhibitory activity with a reported Ki value of approximately 18 6 nM Based on these pharmacological properties amodiaquine dihydrochloride dihydrate holds research potential in investigating histamine metabolism pathways in inflammatory disease models
Apexbio Technology LLC HTH-01-015(Synonyms: HTH01015, WZ4003, NUAK1 inhibitor WZ4003, NUAK1-IN-1, NUAK1 inhibitor, WZ-4003), 10mg, CAS: 1613724-42-7.
HTH-01-015 (CAS 1613724-42-7) is a highly selective inhibitor targeting the NUAK1 kinase exhibiting potent inhibitory activity with an IC50 of approximately 100 nM It specifically blocks NUAK1-mediated phosphorylation of MYPT1 at Ser445 with negligible off-target effects among a comprehensive panel of 139 other kinases Cellular studies demonstrate that treatment with HTH-01-015 reduces migration of mouse embryonic fibroblasts (MEFs) suppresses proliferation in U2OS and MEF cell lines at concentrations around 10 M and significantly inhibits invasion of U2OS cells within 3D Matrigel transwell assays This compound serves as a useful research tool for investigating NUAK1-related signaling pathways in cancer biology and cellular dynamics
Medchemexpress LLC K-Ras-PDE -IN-1 5mg | 1841464-21-8 | 447.50 g/mol | C25H26FN5O2 | 5 MG
K-Ras-PDEδ-IN-1 is a small-molecule competitive inhibitor that binds the farnesyl binding pocket of PDEδ and disrupts PDEδ-K-Ras interaction. It is provided for research use in biochemical and cellular studies and is characterized by nanomolar affinity and high chemical purity. Follow supplier solubility and handling guidance when preparing solutions for in vitro or in vivo use.
- Binds the PDEδ farnesyl pocket with a Kd of ~8 nM.
- High chemical purity (≈99.6% as supplied).
- Soluble in DMSO (12.5 mg/mL); ultrasonic recommended for dissolution.
- Formulation guidance provided for in vivo suspension (10% DMSO, 40% PEG300, 5% Tween-80, 45% saline).
- Available in small research pack sizes suitable for biochemical assays.
eMolecules 1003021-01-9 | (5R)-5-aminopiperidin-2-one hydrochloride | MFCD03094720 | 1g
2-Bromo-4-iodopyridine | Ambeed | 100523-96-4 | MFCD03085768 | 283.894 | C5H3BrIN | 98.000 | Brc1cc(I)ccn1 | 10g | 552669016
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Medchemexpress LLC CCT128930 hydrochloride | 2453324-32-6 | 99.0% | C18H21Cl2N5 | 10MG
CCT128930 hydrochloride is the hydrochloride salt of a selective ATP-competitive AKT inhibitor supplied as a powder for research use. It is employed in cellular assays to probe PI3K/Akt/mTOR signaling, induce cell cycle arrest, and study autophagy; handle and store according to the product SDS and COA.
![eMolecules ChemScene | Ethyl [44-bipiperidine]-1-carboxylate hydrochloride | 100mg | 761228935 | CS-0619155 | 276.81 | C13H25ClN2O2](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502466358.JPG-250.jpg)
eMolecules ChemScene | Ethyl [44-bipiperidine]-1-carboxylate hydrochloride | 100mg | 761228935 | CS-0619155 | 276.81 | C13H25ClN2O2
ChemScene | Ethyl [44-bipiperidine]-1-carboxylate hydrochloride | 100mg | 761228935 | CS-0619155 | 276.810 | C13H25ClN2O2
Matrix Scientific 1-N-BOC-4-aminopiperidine, 87120-72-7, MFCD01076201, 25g
Molecular Formula C10H20N2O2, Purity 98%, Molecular Weight 200.28, Melting Point 44-48°, Boiling Point 80/0.05mm