Piperidines
Selleck Chemical LLC Niraparib tosylate
Niraparib tosylate is a selective inhibitor of PARP1/PARP2 with IC50 of 3 8 nM/2 1 nM Niraparib increases formation of PARP-DNA complexes resulting in DNA damage apoptosis and cell death
Medchemexpress LLC GPR40/FFAR1 modulator 1 | 874755-26-7 | 98.3% | 389.41 | 10 MG
GPR40/FFAR1 modulator 1 is an agonist and an allosteric modulator for Gq-coupled free fatty acid receptor 1 (GPR40/FFAR1).
- Appearance: Solid
- Color: Off-white to light yellow
- Shipping: Room temperature in continental US; may vary elsewhere.
- Storage: 4°C, protected from light. In solvent: -80°C, 6 months; -20°C, 1 month (protect from light).
Medchemexpress LLC BI-9627 hydrochloride | 1422252-46-7 | 98.0% | 392.80 g/mol | C16H20ClF3N4O2 | 10 MG
BI-9627 hydrochloride is the hydrochloride salt of a potent sodium-hydrogen exchanger 1 (NHE1) inhibitor supplied for research use. The compound is intended for biochemical and pharmacological studies of NHE1 activity and is accompanied by analytical documentation to support quality and identity.
- Potent NHE1 inhibition at low nanomolar concentrations.
- Hydrochloride salt form improves solubility for formulation and handling.
- High purity suitable for research applications and analytical studies.
- Characterized molecular weight 392.80 g/mol and formula C16H20ClF3N4O2.
- Supplied with supporting documentation such as COA and analytical data.
Medchemexpress LLC BI-9627 hydrochloride | 1422252-46-7 | 98.0% | 392.80 | 5 MG
BI-9627 hydrochloride | 1422252-46-7 | 98.0% | 392.80 | 5 MG
Medchemexpress LLC 2-(2-phenylethylsulfanyl)pyridine-3-carboxylic acid | 496775-95-2 | MFCD03621206 | 99.8% | 259.32 g·mol⁻1 | C14H13NO2S | 25MG
ML-099 (CID-888706) is a small-molecule pan Ras-related GTPases activator used in biochemical and cell-based research to activate Rac1, Cdc42, Ras, Rab7, and Rab-2A. It is supplied for research use only and is provided in high-purity solid form or as a DMSO solution suitable for in vitro assays.
- Activates multiple small GTPases including Rac1, Cdc42, Ras, Rab7, and Rab-2A.
- High purity suitable for biochemical and cell-based assays (99.8%).
- Available as solid in small milligram quantities and as a 10 mM solution in DMSO.
- Molecular formula C14H13NO2S and molecular weight 259.32 g·mol⁻1.
- Intended for research use only; not for human or clinical use.
Enzo Life Sciences Ceritinib (free base) (50mg). CAS: 1032900-25-6
Ceritinib is a selective inhibitor of ALK, a target found in metastatic non-small cell lung cancer. Purity: ≥99% (HPLC). Solubility: Soluble in DMSO. Long Term Storage: -20°C.
Sigma Aldrich Fine Chemicals Biosciences Paroxetine hydrochloride hemihydrate >=98% (HPLC), powder | 110429-35-1 | MFCD03658863 | 10MG
Paroxetine hydrochloride hemihydrate >=98% (HPLC), powder | Purity: >=98% (HPLC) | Mol Wt: 374.83 | 110429-35-1 | MFCD03658863 | 10MG
Medchemexpress LLC BI-9627 hydrochloride | 1422252-46-7 | 98.0% | 392.80 | 50 MG
BI-9627 hydrochloride is a potent inhibitor of sodium-hydrogen exchanger isoform 1 (NHE1), with IC50 values of 6 nM in intracellular pH recovery (pHi) assays and 31 nM in human platelet swelling assays. It demonstrates over 30-fold selectivity against NHE2 and shows no measurable inhibitory activity against the NHE3 isoform.
- Decreases autophagy in HTR-8/SVneo cells and reduces human sperm pHi.
- Prolongs Ca2+ recovery in hiPSC-CMs; potent in ischemia-reperfusion injury models.
- Low drug-drug interaction (DDI) potential; excellent pharmacokinetics in rat and dog.
- Off-white to light yellow solid appearance.
- Soluble in DMSO (100 mg/mL) and H2O (4.17 mg/mL).
- Solid storage at 4°C; stock solutions at -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC HY-107633 5mg Medchemexpress, A 1120 CAS:1152782-19-8 Purity:>98%
Medchemexpress, HY-107633 5mg A 1120 CAS:1152782-19-8 A 1120, a nonretinoid retinol-binding protein 4 (RBP4) antagonist, has a high affinity with the K i value of 8.3 nM, which disrupts the interaction between RBP4 and its binding partner transthyretin [1] [2] . Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
eMolecules 1032900-25-6 | CERITINIB | MFCD26142648 | 1g
Ambeed | 2-(Dibenzo[bd]furan-3-yl)-4455-tetramethyl-132-dioxaborolane | 1g | 672837972 | A1150306 | 1056113-50-8 | MFCD30258409 | 294.160 | C18H19BO3
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Medchemexpress LLC PI 3 Kinase p150 Antibody (YA2823) | 50 UL
This rabbit recombinant monoclonal antibody, PI 3 Kinase p150 Antibody (YA2823), is designed for laboratory research applications. It is reactive with human, mouse, and rat samples and is supplied in a phosphate-buffered saline solution containing BSA, sodium azide, and glycerol.
- Rabbit host
- Reactivity across human, mouse, and rat
- Suitable for Western Blot (WB), Immunohistochemistry-Paraffin (IHC-P), Immunocytochemistry/Immunofluorescence (ICC/IF), and Flow Cytometry (FC) applications
- Supplied in 10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide, and 50% glycerol
- Recommended storage at -20°C for up to 1 year
- Observed molecular weight of 150 kDa
- Antibody type for research use
eMolecules 1240299-33-5 | Medchem Express | AZD3514 | 5mg | 446267195 | HY-16079 | MFCD25976791 | 519.573 | C25H32F3N7O2
Ambeed | (2-Oxo-13-dioxolan-4-yl)methyl methacrylate | 1g | 672523658 | A987700 | 13818-44-5 | MFCD28964174 | 186.163 | C8H10O5
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Medchemexpress LLC HY-50844 500mg , Ibutamoren (Mesylate) MK-677;MK-0677 CAS:159752-10-0 Purity:98%
Medchemexpress, HY-50844 500mg Ibutamoren (Mesylate) MK-677;MK-0677 CAS:159752-10-0 Formula:C28H40N4O8S2 Purity:98% Ibutamoren (Mesylate) is a potent, non-peptide Growth hormone secretagogue receptor (GHSR) agonist. Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Animal-free IL-4 protein, pig (His) | 98.0% | 50UG
Recombinant porcine interleukin-4 (IL-4) supplied lyophilized and produced in E. coli. The protein contains a C-terminal 6xHis tag, has an approximate molecular weight of 15 kDa, and is ≥98.0% pure by reducing SDS-PAGE. Biological activity is validated (ED50 <0.6 ng/mL); reconstitute to 100-200 μg/mL and store lyophilized at -20 °C or aliquot and freeze at -20 °C/-80 °C for long-term storage.
- Recombinant porcine interleukin-4 in lyophilized form.
- C-terminal 6xHis tag for detection or purification.
- Produced in E. coli expression system.
- Approximate molecular weight of 15 kDa.
- Purity of 98.0% as determined by SDS-PAGE.
- Biologically active with ED50 <0.6 ng/mL in TF-1 assay.
- Formulated from 0.22 μm filtered PBS, pH 7.4.
- Stable lyophilized at -20 °C; aliquot and store at -20 °C/-80 °C after reconstitution.