Piperidines

Medchemexpress LLC JNJ-1013 | 2597343-08-1 | 99.8% | 878.05 g/mol | C46H55N9O7S | 10 MG

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JNJ-1013 is a research-grade PROTAC degrader that selectively targets interleukin-1 receptor-associated kinase 1 (IRAK1). It induces IRAK1 degradation, modulates downstream signaling, and has been characterized in cellular assays for apoptosis and pathway inhibition. Supplied as a high-purity solid, it is intended for in vitro biochemical and cellular studies.

• Potent IRAK1 activity with reported IC50 values: 72 nM (IRAK1), 443 nM (IRAK4), 1,071 nM (VHL FP).
• High reported purity (99.8%).
• Molecular weight 878.05 g/mol; formula C46H55N9O7S.
• Soluble in DMSO at 25 mg/mL; may require warming or sonication.
• Recommended storage: protect from light at 4°C; in solution store at -80°C for long-term or -20°C up to one month.
• Suitable for in vitro target validation, signaling pathway studies, and apoptosis assays.

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Selleck Chemical LLC Donepezil S5073-25mg

Donepezil (Aricept Donepezilo) is a piperidine based potent specific non-competitive and reversible inhibitor of acetylcholinesterase (AChE) used for the treatment of mild to moderate dementia of the Alzheimer s type

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Medchemexpress LLC JNJ-1013 | 2597343-08-1 | C46H55N9O7S | 25 MG

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JNJ-1013 is a potent and selective IRAK1 PROTAC degrader. It has IC50 values of 72 nM for IRAK1, 443 nM for IRAK4, and 1071 nM for VHL FP. It induces apoptosis, increases the expression of cleavaged PARP, and decreases the expression of IRAK1, p-IKBα, and pSTAT3(Tyr705).

• Potent and selective IRAK1 PROTAC degrader
• IRAK1 IC50: 72 nM
• IRAK4 IC50: 443 nM
• VHL FP IC50: 1071 nM
• Induces apoptosis and increases cleaved PARP expression
• Decreases IRAK1, p-IKBα, and pSTAT3(Tyr705) expression
• Degrades IRAK1 protein with a DC50 value of 3 nM in a dose-dependent manner
• Demonstrated decreased IRAK1 expression in HEK293T cells (1.5-10000 nM)

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Chem-Impex International, Inc. 1-Benzyl-4-formylpiperidine | 22065-85-6 | MFCD02258902 | 1G

1-Benzyl-4-formylpiperidine, 22065-85-6, MFCD02258902, 1G

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eMolecules​ 95798-23-5 | BENZYL 4-HYDROXYPIPERIDINE-1-CARBOXYLATE | AstaTech | MFCD01863722 | 235.283 | C13H17NO3 | 95.000 | OC1CCN(CC1)C(=O)OCc1ccccc1 | 100g | 416218261

BENZYL 4-HYDROXYPIPERIDINE-1-CARBOXYLATE | AstaTech | 95798-23-5 | MFCD01863722 | 235.283 | C13H17NO3 | 95.000 | OC1CCN(CC1)C(=O)OCc1ccccc1 | 100g | 416218261

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eMolecules​ 95798-23-5 | BENZYL 4-HYDROXYPIPERIDINE-1-CARBOXYLATE | AstaTech | MFCD01863722 | 235.283 | C13H17NO3 | 95.000 | OC1CCN(CC1)C(=O)OCc1ccccc1 | 25g | 248484948

BENZYL 4-HYDROXYPIPERIDINE-1-CARBOXYLATE | AstaTech | 95798-23-5 | MFCD01863722 | 235.283 | C13H17NO3 | 95.000 | OC1CCN(CC1)C(=O)OCc1ccccc1 | 25g | 248484948

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eMolecules​ 95798-23-5 | Benzyl 4-hydroxypiperidine-1-carboxylate | Oakwood Chemical | MFCD01863722 | 235.283 | C13H17NO3 | 97.000 | OC1CCN(CC1)C(=O)OCc1ccccc1 | 1g | 704987971

Benzyl 4-hydroxypiperidine-1-carboxylate | Oakwood Chemical | 95798-23-5 | MFCD01863722 | 235.283 | C13H17NO3 | 97.000 | OC1CCN(CC1)C(=O)OCc1ccccc1 | 1g | 704987971

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Ambeed AMBEED

5000894566 5-HYDROXYPIPERIDINE-2-CA 100MG

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Chemscene CHEMSCENE

5000579903 R-1-BENZYLPIPERIDIN-3-AMINE 5G

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Chemscene CHEMSCENE

5000577342 R-1-BOC-3-HYDROXYPIPERIDINE 1G

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eMolecules​ 84243-24-3 | benzyl 3-oxo-1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate | MFCD09758966 | 1g

Pharmablock | benzyl 3-oxo-1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate | 1g | 551182164 | PBZS2205 | 84243-24-3 | MFCD09758966 | 304.346 | C16H20N2O4

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Ambeed AMBEED

5000847815 4- 4-HYDROXYPIPERIDIN-1 250MG

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Ambeed AMBEED

5000849659 4- 4-HYDROXYPIPERIDIN-1 1G

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eMolecules​ 612847-09-3 | Medchem Express | AKT inhibitor VIII | 5mg | 446258191 | HY-10355 | MFCD23843802 | 551.654 | C34H29N7O

Medchem Express | AKT inhibitor VIII | 5mg | 446258191 | HY-10355 | 612847-09-3 | MFCD23843802 | 551.654 | C34H29N7O

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Medchemexpress LLC Valopicitabine (dihydrochloride) | 640725-71-9 | MFCD34589916 | 99.8% | 429.3 g/mol | C15H26Cl2N4O6 | 50 MG

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Valopicitabine (dihydrochloride) is the dihydrochloride salt of valopicitabine (NM-283), a nucleoside-analog prodrug of 2'-C-methylcytidine with activity against hepatitis C virus through inhibition of the NS5B RNA polymerase. It is provided as a research reagent for biochemical and antiviral studies.

• High purity suitable for analytical and biological assays.
• Dihydrochloride salt form, improving aqueous solubility compared with the free base.
• Acts as an orally bioavailable prodrug of an HCV polymerase inhibitor.
• Molecular weight 429.3 g/mol; formula C15H26Cl2N4O6.
• Supplied in small research quantities (e.g., 50 MG) for laboratory use.
• Accompanied by analytical documentation such as COA, H NMR, and LC-MS.

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