Piperidines
Apexbio Technology LLC Quisinostat dihydrochloride 875320-31-3 5mg
Quisinostat dihydrochloride (CAS 875320-31-3) also known as JNJ-26481585 dihydrochloride is an orally bioavailable pan-histone deacetylase (HDAC) inhibitor It potently suppresses the enzymatic activity of several HDAC isoforms including HDAC1 (IC50 0 11 nM) HDAC2 (IC50 0 33 nM) HDAC4 (IC50 0 64 nM) HDAC10 (IC50 0 46 nM) and HDAC11 (IC50 0 37 nM) By interfering with histone deacetylation Quisinostat dihydrochloride induces apoptosis and cell cycle arrest in tumor cells This compound is widely utilized in studies addressing tumor biology and epigenetic regulation
Apexbio Technology LLC Quisinostat dihydrochloride 875320-31-3 10mg
Quisinostat dihydrochloride (CAS 875320-31-3) also known as JNJ-26481585 dihydrochloride is an orally bioavailable pan-histone deacetylase (HDAC) inhibitor It potently suppresses the enzymatic activity of several HDAC isoforms including HDAC1 (IC50 0 11 nM) HDAC2 (IC50 0 33 nM) HDAC4 (IC50 0 64 nM) HDAC10 (IC50 0 46 nM) and HDAC11 (IC50 0 37 nM) By interfering with histone deacetylation Quisinostat dihydrochloride induces apoptosis and cell cycle arrest in tumor cells This compound is widely utilized in studies addressing tumor biology and epigenetic regulation
Apexbio Technology LLC PI-1840 1401223-22-0 50mg
PI-1840 (CAS 1401223-22-0) is a potent selective and rapidly reversible noncovalent inhibitor of the proteasome chymotrypsin-like (CT-L) activity It exhibits an IC50 of 27 nM against CT-L catalytic function of the proteasome with significantly greater selectivity over other proteolytic activities including PGPH-L and T-L In MDA-MB-468 human breast cancer cells PI-1840 inhibits CT-L activity (IC50 0 37 M) suppresses cell viability and proliferation and induces accumulation of CT-L substrates such as I B- p27 and Bax ultimately triggering apoptosis via PARP cleavage and caspase-3 activation In vivo PI-1840 markedly reduces tumor growth in a breast cancer xenograft model This compound is valuable for investigating proteasome function apoptosis and cancer biology