Piperidines
4-Amino-1-isopropylpiperidine 98.0+%, TCI America™
CAS: 127285-08-9 Molecular Formula: C8H18N2 Molecular Weight (g/mol): 142.25 MDL Number: MFCD03411606 InChI Key: ZRQQXFMGYSOKDF-UHFFFAOYSA-N PubChem CID: 3163333 IUPAC Name: 1-(propan-2-yl)piperidin-4-amine SMILES: CC(C)N1CCC(N)CC1
1-Methyl-4-(methylamino)piperidine 97.0+%, TCI America™
CAS: 73579-08-5 Molecular Formula: C7H16N2 Molecular Weight (g/mol): 128.219 MDL Number: MFCD00006498 InChI Key: XRYGCVVVDCEPRL-UHFFFAOYSA-N PubChem CID: 566323 IUPAC Name: N,1-dimethylpiperidin-4-amine SMILES: CNC1CCN(CC1)C
Medchemexpress LLC JNJ-1013 | 2597343-08-1 | C46H55N9O7S | 50 MG
JNJ-1013 is a potent and selective IRAK1 PROTAC degrader. It induces apoptosis, increases the expression of cleaved PARP, and decreases the expression of IRAK1, p-IKBα, and pSTAT3(Tyr705).
- Potent and selective IRAK1 PROTAC degrader
- IC50s of 72 nM for IRAK1, 443 nM for IRAK4, and 1071 nM for VHL FP
- Induces apoptosis and increases cleaved PARP expression
- Decreases expression of IRAK1, p-IKBα, and pSTAT3(Tyr705)
Medchemexpress LLC JNJ-1013 | 2597343-08-1 | C46H55N9O7S | 25 MG
JNJ-1013 is a potent and selective IRAK1 PROTAC degrader. It has IC50 values of 72 nM for IRAK1, 443 nM for IRAK4, and 1071 nM for VHL FP. It induces apoptosis, increases the expression of cleavaged PARP, and decreases the expression of IRAK1, p-IKBα, and pSTAT3(Tyr705).
- Potent and selective IRAK1 PROTAC degrader
- IRAK1 IC50: 72 nM
- IRAK4 IC50: 443 nM
- VHL FP IC50: 1071 nM
- Induces apoptosis and increases cleaved PARP expression
- Decreases IRAK1, p-IKBα, and pSTAT3(Tyr705) expression
- Degrades IRAK1 protein with a DC50 value of 3 nM in a dose-dependent manner
- Demonstrated decreased IRAK1 expression in HEK293T cells (1.5-10000 nM)
Medchemexpress LLC JNJ-1013 | 2597343-08-1 | C46H55N9O7S | 100 MG
JNJ-1013 is a potent and selective IRAK1 PROTAC degrader. It functions by inducing apoptosis and increasing the expression of cleaved PARP. This compound also plays a role in decreasing the expression of IRAK1, p-IKBα, and pSTAT3(Tyr705).
- Potent and selective IRAK1 PROTAC degrader
- Induces apoptosis
- Increases the expression of cleaved PARP
- Decreases the expression of IRAK1, p-IKBα, and pSTAT3(Tyr705)
Medchemexpress LLC JNJ-1013 | 2597343-08-1 | 99.8% | 878.05 g/mol | C46H55N9O7S | 10 MG
JNJ-1013 is a research-grade PROTAC degrader that selectively targets interleukin-1 receptor-associated kinase 1 (IRAK1). It induces IRAK1 degradation, modulates downstream signaling, and has been characterized in cellular assays for apoptosis and pathway inhibition. Supplied as a high-purity solid, it is intended for in vitro biochemical and cellular studies.
- Potent IRAK1 activity with reported IC50 values: 72 nM (IRAK1), 443 nM (IRAK4), 1,071 nM (VHL FP).
- High reported purity (99.8%).
- Molecular weight 878.05 g/mol; formula C46H55N9O7S.
- Soluble in DMSO at 25 mg/mL; may require warming or sonication.
- Recommended storage: protect from light at 4°C; in solution store at -80°C for long-term or -20°C up to one month.
- Suitable for in vitro target validation, signaling pathway studies, and apoptosis assays.
![eMolecules tert-butyl 1-oxo-2-oxa-8-azaspiro[4.5]decane-8-carboxylate | 154348-08-0 | MFCD13184732 | 1g](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502156949.JPG-250.jpg)
eMolecules tert-butyl 1-oxo-2-oxa-8-azaspiro[4.5]decane-8-carboxylate | 154348-08-0 | MFCD13184732 | 1g
Pharmablock | tert-butyl 1-oxo-2-oxa-8-azaspiro[4.5]decane-8-carboxylate | 1g | 551214552 | PB07465 | | 154348-08-0 | MFCD13184732 | 255.314 | C13H21NO4
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