Piperidines
Cayman Chemical 4- N-Boc-amInopIperIdIn 5g
An alkaloid with mutagenic activity forms DNA adducts under anaerobic conditions in vitro at 0 4 mM oral administration induces bladder forestomach and kidney DNA adduct formation in rats at 0 03 mmol/kg reduces body weight and urine concentrations of sodium potassium and calcium enlarges the liver and kidneys and increases blood concentrations of hemoglobin and hematocrit in rats
Cayman Chemical 4- N-Boc-amInopIperIdIn 1g
An alkaloid with mutagenic activity forms DNA adducts under anaerobic conditions in vitro at 0 4 mM oral administration induces bladder forestomach and kidney DNA adduct formation in rats at 0 03 mmol/kg reduces body weight and urine concentrations of sodium potassium and calcium enlarges the liver and kidneys and increases blood concentrations of hemoglobin and hematocrit in rats
Apexbio Technology LLC SAR7334 1333210-07-3 2mg
SAR7334 (CAS 1333210-07-3) is a small molecule inhibitor that selectively targets the transient receptor potential cation channel subfamily C member 6 (TRPC6) By inhibiting TRPC6-mediated calcium influx SAR7334 is utilized to investigate TRPC6-related signal transduction pathways in cellular and preclinical studies This compound serves as a valuable tool for elucidating the role of TRPC6 in pathophysiological processes including those related to kidney function and vascular regulation Its application aids in advancing the understanding of TRPC6-associated diseases and potential therapeutic interventions
Apexbio Technology LLC Vanoxerine dihydrochloride 67469-78-7 25mg
Vanoxerine dihydrochloride is a small-molecule inhibitor targeting the dopamine transporter (DAT1) human ether- -go-go-related gene (hERG Kv11 1) potassium channel cardiac sodium channel (hNaV1 5) and L-type calcium channels (ICa L) It modulates neurotransmitter uptake and cardiac ion channel conductance thereby regulating synaptic dopamine levels and cardiac electrophysiology Vanoxerine dihydrochloride exerts its biological activity primarily through inhibition of dopamine reuptake and blockade of multiple cardiac ion channels It demonstrates antagonist activity at DAT1 (Ki 16 9 nM) potent inhibition of hERG channels (IC50 0 84 nM) and inhibitory effects on hNaV1 5 (IC50 830 nM) and ICa L (IC50 320 nM) Based on these pharmacological properties vanoxerine dihydrochloride holds research potential in cardiac arrhythmia studies
Apexbio Technology LLC Vanoxerine dihydrochloride 67469-78-7 10mg
Vanoxerine dihydrochloride is a small-molecule inhibitor targeting the dopamine transporter (DAT1) human ether- -go-go-related gene (hERG Kv11 1) potassium channel cardiac sodium channel (hNaV1 5) and L-type calcium channels (ICa L) It modulates neurotransmitter uptake and cardiac ion channel conductance thereby regulating synaptic dopamine levels and cardiac electrophysiology Vanoxerine dihydrochloride exerts its biological activity primarily through inhibition of dopamine reuptake and blockade of multiple cardiac ion channels It demonstrates antagonist activity at DAT1 (Ki 16 9 nM) potent inhibition of hERG channels (IC50 0 84 nM) and inhibitory effects on hNaV1 5 (IC50 830 nM) and ICa L (IC50 320 nM) Based on these pharmacological properties vanoxerine dihydrochloride holds research potential in cardiac arrhythmia studies