Pyrazines
Medchemexpress LLC MCB-22-174 | 3058199-58-6 | 99.8% | 429.37 | 5 MG
MCB-22-174 is a deuterated Piezo1 agonist with an EC50 value of 6.28 μM. It activates the CaMKII/ERK signaling pathway and initiates Ca2+ influx in rMSCs. It decreases the expression of chondrogenesis markers (Comp, Acan) and adipogenesis markers (Lpl, Fabp4) in MSCs. This compound can improve bone quality in hind-limb unloading (HU) model rats and can be used for the study of disuse osteoporosis (OP).
- Deuterated Piezo1 agonist
- Activates the CaMKII/ERK signaling pathway
- Initiates Ca2+ influx in rMSCs
- Decreases expression of chondrogenesis markers (Comp, Acan) in MSCs
- Decreases expression of adipogenesis markers (Lpl, Fabp4) in MSCs
- Effectively improves bone quality in hind-limb unloading (HU) model rats
- Can be used for the study of disuse osteoporosis (OP)
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
eMolecules Pharmablock / 22-dimethyl-3-oxocyclobutane-1-carboxylic acid / 25mg / 551273227 / PBN20121759 / 0.000 / 3183-43-5 / MFCD23106160 / 142.154 / C7H10O3
Pharmablock / 22-dimethyl-3-oxocyclobutane-1-carboxylic acid / 25mg / 551273227 / PBN20121759 / 0.000 / 3183-43-5 / MFCD23106160 / 142.154 / C7H10O3
TARGETMOL CHEMICALS INC PACRITINIB 25MG
Also available in 2 mg 5 mg 10 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Pacritinib (SB1518) (SB1518) is an effective and specific inhibitor of JAK2 and FLT3 (IC50 23/22 nM in cell-free assays). purity: 99%
TARGETMOL CHEMICALS INC ICA-121431 25MG
Also available in 2 mg 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. ICA-121431 (22-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl) is a nanomolar potent small molecule Nav1.7 channel inhibitor with IC50 of 19 nM for rat Nav1.7 with little or no activity against human Nav1.5 or Nav1.7 channels. purity: 98%