GPI-1046 is an orally active, non-immunosuppressive immunophilin ligand with reported neuroprotective properties. It has been shown to reduce ethanol intake by upregulating the glutamate transporter GLT1 and to improve HIV-associated sensory neuropathy by attenuating store-operated calcium (SOC) entry. The compound is provided as a high-purity research chemical in solid and ready-to-use DMSO formulations for preclinical pharmacology studies.
- Has neuroprotective activity demonstrated in preclinical studies.
- Upregulates the glutamate transporter GLT1 in relevant brain regions.
- Attenuates store-operated calcium entry implicated in neuropathy.
- Provided at high reported purity for research applications.
- Available as solid packs and DMSO solutions for dosing flexibility.