Pyridines and derivatives
2-Fluoro-4-iodo-5-methylpyridine 98.0+%, TCI America™
CAS: 153034-94-7 Molecular Formula: C6H5FIN Molecular Weight (g/mol): 237.016 MDL Number: MFCD03095297 InChI Key: BVKQLNXPPQEELX-UHFFFAOYSA-N Synonym: 2-fluoro-4-iodo-5-picoline,2-fluoro-4-iodo-5-methyl-pyridine,6-fluoro-4-iodo-b-picoline,6-fluoro-4-iodo-3-picoline,2-fluoro-4-iodo-5-methyl pyridine,pyridine,2-fluoro-4-iodo-5-methyl,pyridine, 2-fluoro-4-iodo-5-methyl,pubchem1305,acmc-20el7f,abbypharma ap-30-1289 PubChem CID: 10060052 IUPAC Name: 2-fluoro-4-iodo-5-methylpyridine SMILES: CC1=CN=C(C=C1I)F
4-Chloro-3-fluoropyridine, 95%
CAS: 2546-56-7 Molecular Formula: C5H3ClFN Molecular Weight (g/mol): 131.53 MDL Number: MFCD03453233 InChI Key: BEQUUSCRAKEKQM-UHFFFAOYSA-N Synonym: pyridine, 4-chloro-3-fluoro,3-fluoro-4-chloro pyridine,3-fluoro-4-chloropyridine hydrochloride,pubchem6667,4-chloro-3fluoropyridine,3-fluoro-4-chloropyridine,acmc-209x6p,4-chloro-3-fluoro-pyridin,3-fluoro-4-chloro-pyridine,4-chloro-3-fluoro-pyridine PubChem CID: 3852429 IUPAC Name: 4-chloro-3-fluoropyridine SMILES: FC1=C(Cl)C=CN=C1
7-Aminoindole, 95%, Thermo Scientific™
CAS: 5192-04-1 Molecular Formula: C8H8N2 Molecular Weight (g/mol): 132.16 InChI Key: WTFWZOSMUGZKNZ-UHFFFAOYSA-N Synonym: 2-chloro-6-hydrazinopyridine,2-chloro-6-hydrazinylpyridine,6-chloro-2-pyridyl hydrazine,6-chloro-2-pyridylhydrazine,2 1h-pyridinone, 6-chloro-, hydrazone,pubchem12983,acmc-1awi0,2-hydrazino-6-chloropyridine,6-chloro-2-hydrazinopyridine,6-chloro-2-hydrazonopyridine PubChem CID: 320004 IUPAC Name: 1H-indol-7-amine SMILES: NC1=C2NC=CC2=CC=C1
4-Hydroxypyridine, 95%
CAS: 626-64-2 Molecular Formula: C5H5NO Molecular Weight (g/mol): 95.10 MDL Number: MFCD00006419,MFCD00040458 InChI Key: GCNTZFIIOFTKIY-UHFFFAOYSA-N Synonym: 4-hydroxypyridine,pyridin-4-ol,4-pyridinol,4-pyridone,4 1h-pyridinone,pyridin-4 1h-one,4-oxopyridine,4-pyridinone,4-pyridol,gamma-hydroxypyridine PubChem CID: 12290 IUPAC Name: 1H-pyridin-4-one SMILES: O=C1C=CNC=C1
4-Aminomethyl-2-chloropyridine, 95%
CAS: 144900-57-2 Molecular Formula: C6H7ClN2 Molecular Weight (g/mol): 142.59 InChI Key: GGHCWJWUOSNCSK-UHFFFAOYSA-N Synonym: 2-chloropyridin-4-yl methanamine,4-pyridinemethanamine, 2-chloro,2-chloropyridin-4-yl methylamine,4-aminomethyl-2-chloropyridine,2-chloro-4-aminomethylpyridine,2-chloro-4-pyridyl methylamine,1-2-chloro-4-pyridinyl methanamine,2-chloro-4-pyridinemethanamine,1-2-chloropyridin-4-yl methanamine,c-2-chloro-pyridin-4-yl-methylamine PubChem CID: 2794167 IUPAC Name: (2-chloropyridin-4-yl)methanamine SMILES: C1=CN=C(C=C1CN)Cl
4-Nitro-2,3-lutidine N-oxide, 97%, Thermo Scientific™
CAS: 37699-43-7 Molecular Formula: C7H8N2O3 Molecular Weight (g/mol): 168.15 MDL Number: MFCD00065172 InChI Key: CFMTVTYBZMKULI-UHFFFAOYSA-N Synonym: 2,3-dimethyl-4-nitropyridine-n-oxide,2,3-dimethyl-4-nitropyridine 1-oxide,2,3-dimethyl-4-nitropyridine n-oxide,4-nitro-2,3-lutidine-n-oxide,pyridine, 2,3-dimethyl-4-nitro-, 1-oxide,2,3-dimethyl-4-nitropyridin-1-ium-1-olate,4-nitro-2,3-lutidine n-oxide,4-nitro-2,3-dimethylpyridine n-oxide,2,3-dimethyl-4-nitro-pyridine 1-oxide,2,3-dimethyl-4-nitro-1-oxido-pyridin-1-ium PubChem CID: 148223 IUPAC Name: 2,3-dimethyl-4-nitro-1-oxidopyridin-1-ium SMILES: CC1=C(C)[N+]([O-])=CC=C1[N+]([O-])=O
Apexbio Technology LLC LJI308 1627709-94-7 100mg
LJI308 (CAS 1627709-94-7) is a potent and selective small-molecule inhibitor of p90 ribosomal S6 kinases (RSK1 RSK2 RSK3) with reported IC50 values ranging from 0 004 to 0 013 mM By targeting RSK kinases downstream effectors in the ERK/MAPK pathway LJI308 modulates signaling processes involved in cell survival proliferation and polarity In cellular assays LJI308 demonstrates concentration-dependent inhibition of colony formation and cell growth in cancer cell lines such as MDA-MB-231 and H358 while exerting minimal effects on non-tumorigenic cells LJI308 is utilized in studies exploring RSK signaling chemoresistance and the elimination of cancer stem cells particularly in triple-negative breast cancer models
Apexbio Technology LLC YM155 781661-94-7 100mg
YM155 (Sepantronium Bromide CAS 781661-94-7) is a small-molecule inhibitor targeting survivin the smallest protein member of the inhibitor of apoptosis (IAP) gene family YM155 potently suppresses survivin expression while demonstrating minimal influence on other IAP family members or BCL-2-associated proteins Preclinical research shows YM155 inhibits proliferation and induces apoptosis across various human cancer cell lines including non-small cell lung cancer (NSCLC) melanoma bladder cancer aggressive non-Hodgkin lymphoma triple-negative breast cancer (TNBC) and Wilms tumor models In animal xenograft studies YM155 administration results in tumor regression reduces spontaneous metastasis and notably prolongs survival
Apexbio Technology LLC LJI308 1627709-94-7 10mg
LJI308 (CAS 1627709-94-7) is a potent and selective small-molecule inhibitor of p90 ribosomal S6 kinases (RSK1 RSK2 RSK3) with reported IC50 values ranging from 0 004 to 0 013 mM By targeting RSK kinases downstream effectors in the ERK/MAPK pathway LJI308 modulates signaling processes involved in cell survival proliferation and polarity In cellular assays LJI308 demonstrates concentration-dependent inhibition of colony formation and cell growth in cancer cell lines such as MDA-MB-231 and H358 while exerting minimal effects on non-tumorigenic cells LJI308 is utilized in studies exploring RSK signaling chemoresistance and the elimination of cancer stem cells particularly in triple-negative breast cancer models
Apexbio Technology LLC LJI308 1627709-94-7 25mg
LJI308 (CAS 1627709-94-7) is a potent and selective small-molecule inhibitor of p90 ribosomal S6 kinases (RSK1 RSK2 RSK3) with reported IC50 values ranging from 0 004 to 0 013 mM By targeting RSK kinases downstream effectors in the ERK/MAPK pathway LJI308 modulates signaling processes involved in cell survival proliferation and polarity In cellular assays LJI308 demonstrates concentration-dependent inhibition of colony formation and cell growth in cancer cell lines such as MDA-MB-231 and H358 while exerting minimal effects on non-tumorigenic cells LJI308 is utilized in studies exploring RSK signaling chemoresistance and the elimination of cancer stem cells particularly in triple-negative breast cancer models
Apexbio Technology LLC LJI308 1627709-94-7 5mg
LJI308 (CAS 1627709-94-7) is a potent and selective small-molecule inhibitor of p90 ribosomal S6 kinases (RSK1 RSK2 RSK3) with reported IC50 values ranging from 0 004 to 0 013 mM By targeting RSK kinases downstream effectors in the ERK/MAPK pathway LJI308 modulates signaling processes involved in cell survival proliferation and polarity In cellular assays LJI308 demonstrates concentration-dependent inhibition of colony formation and cell growth in cancer cell lines such as MDA-MB-231 and H358 while exerting minimal effects on non-tumorigenic cells LJI308 is utilized in studies exploring RSK signaling chemoresistance and the elimination of cancer stem cells particularly in triple-negative breast cancer models
Apexbio Technology LLC LJI308 1627709-94-7 50mg
LJI308 (CAS 1627709-94-7) is a potent and selective small-molecule inhibitor of p90 ribosomal S6 kinases (RSK1 RSK2 RSK3) with reported IC50 values ranging from 0 004 to 0 013 mM By targeting RSK kinases downstream effectors in the ERK/MAPK pathway LJI308 modulates signaling processes involved in cell survival proliferation and polarity In cellular assays LJI308 demonstrates concentration-dependent inhibition of colony formation and cell growth in cancer cell lines such as MDA-MB-231 and H358 while exerting minimal effects on non-tumorigenic cells LJI308 is utilized in studies exploring RSK signaling chemoresistance and the elimination of cancer stem cells particularly in triple-negative breast cancer models
Apexbio Technology LLC YM155 781661-94-7 25mg
YM155 (Sepantronium Bromide CAS 781661-94-7) is a small-molecule inhibitor targeting survivin the smallest protein member of the inhibitor of apoptosis (IAP) gene family YM155 potently suppresses survivin expression while demonstrating minimal influence on other IAP family members or BCL-2-associated proteins Preclinical research shows YM155 inhibits proliferation and induces apoptosis across various human cancer cell lines including non-small cell lung cancer (NSCLC) melanoma bladder cancer aggressive non-Hodgkin lymphoma triple-negative breast cancer (TNBC) and Wilms tumor models In animal xenograft studies YM155 administration results in tumor regression reduces spontaneous metastasis and notably prolongs survival
Apexbio Technology LLC LJI308 1627709-94-7 2mg
LJI308 (CAS 1627709-94-7) is a potent and selective small-molecule inhibitor of p90 ribosomal S6 kinases (RSK1 RSK2 RSK3) with reported IC50 values ranging from 0 004 to 0 013 mM By targeting RSK kinases downstream effectors in the ERK/MAPK pathway LJI308 modulates signaling processes involved in cell survival proliferation and polarity In cellular assays LJI308 demonstrates concentration-dependent inhibition of colony formation and cell growth in cancer cell lines such as MDA-MB-231 and H358 while exerting minimal effects on non-tumorigenic cells LJI308 is utilized in studies exploring RSK signaling chemoresistance and the elimination of cancer stem cells particularly in triple-negative breast cancer models
Apexbio Technology LLC Milnacipran HCl 101152-94-7 50mg
Milnacipran hydrochloride (CAS 101152-94-7) is a small molecule classified as a serotonin-norepinephrine reuptake inhibitor (SNRI) It acts by selectively inhibiting the reuptake of both serotonin and norepinephrine in the central nervous system thereby modulating synaptic neurotransmitter levels Milnacipran HCl has been investigated for its ability to influence neurochemical pathways implicated in pain processing and mood regulation It is utilized in biomedical research to study the pathophysiology of fibromyalgia and related disorders involving monoaminergic dysfunction