Pyridines and derivatives
4-Bromo-2-methylpyridine, 97%
CAS: 22282-99-1 Molecular Formula: C6H6BrN Molecular Weight (g/mol): 172.03 MDL Number: MFCD03788196 InChI Key: JFBMFWHEXBLFCR-UHFFFAOYSA-N Synonym: 4-bromo-2-picoline,2-methyl-4-bromopyridine,4-bromo-2-methyl-pyridine,pyridine, 4-bromo-2-methyl,4-bromopicoline,zlchem 422,pubchem4035,acmc-209fui,4-bromo-methyl-pyridine PubChem CID: 2762835 IUPAC Name: 4-bromo-2-methylpyridine SMILES: CC1=CC(Br)=CC=N1
2-Bromo-3-(trifluoromethyl)pyridine, 98%
CAS: 175205-82-0 Molecular Formula: C6H3BrF3N Molecular Weight (g/mol): 225.996 MDL Number: MFCD00153084 InChI Key: OFGSIPQYQUVVPL-UHFFFAOYSA-N Synonym: 2-bromo-3-trifluoromethyl pyridine,2-bromo-3-trifluorormethyl pyridine,pyridine, 2-bromo-3-trifluoromethyl,2-bromo-3-trifluormethyl-pyridine,pubchem2999,acmc-1bx8n,ksc174i2d,tpc-py049,buttpark 27\06-85 PubChem CID: 5193820 IUPAC Name: 2-bromo-3-(trifluoromethyl)pyridine SMILES: C1=CC(=C(N=C1)Br)C(F)(F)F
2,5-Dichloro-4-(trifluoromethyl)pyridine, 97%, Thermo Scientific Chemicals
CAS: 89719-92-6 Molecular Formula: C6H2Cl2F3N Molecular Weight (g/mol): 215.98 MDL Number: MFCD09749663 InChI Key: GFTRYJQAASFSIB-UHFFFAOYSA-N Synonym: 2,5-dichloro-4-trifluoromethyl pyridine,pyridine, 2,5-dichloro-4-trifluoromethyl,acmc-20dwro PubChem CID: 26986016 IUPAC Name: 2,5-dichloro-4-(trifluoromethyl)pyridine SMILES: FC(F)(F)C1=CC(Cl)=NC=C1Cl
3-Bromo-2-methylpyridine 98.0+%, TCI America™
CAS: 38749-79-0 Molecular Formula: C6H6BrN Molecular Weight (g/mol): 172.03 MDL Number: MFCD00191224 InChI Key: AIPWPTPHMIYYOX-UHFFFAOYSA-N Synonym: 3-bromo-2-picoline,2-methyl-3-bromopyridine,3-bromo-2-methyl-pyridine,pyridine, 3-bromo-2-methyl,2-methyl-3-bromo pyridine,pubchem1220,3-brom-2-methylpyridin,acmc-209j1t,3-bromo-2-methyl pyridine,ksc497m1l PubChem CID: 1201003 IUPAC Name: 3-bromo-2-methylpyridine SMILES: CC1=C(Br)C=CC=N1
3-Bromo-2-fluoropyridine 98.0+%, TCI America™
CAS: 36178-05-9 Molecular Formula: C5H3BrFN Molecular Weight (g/mol): 175.988 MDL Number: MFCD04112496 InChI Key: KESUTBOSNOHAMK-UHFFFAOYSA-N PubChem CID: 2762778 IUPAC Name: 3-bromo-2-fluoropyridine SMILES: C1=CC(=C(N=C1)F)Br
2,4-Dichloropyridine 98.0+%, TCI America™
CAS: 26452-80-2 Molecular Formula: C5H3Cl2N Molecular Weight (g/mol): 147.986 MDL Number: MFCD00955618 InChI Key: TYPVHTOETJVYIV-UHFFFAOYSA-N Synonym: pyridine, 2,4-dichloro,2,4-dichloro pyridine,2,4-dichoropyridine,2, 4-dichloropyridine,2,4-dichloro-pyridine,2,4-dichlorpyridin,2,4-dichlorpyridine,2,4-dichloropyrdine,pubchem3531,acmc-1cnvt PubChem CID: 33515 IUPAC Name: 2,4-dichloropyridine SMILES: C1=CN=C(C=C1Cl)Cl
4-Bromo-2-methylpyridine 98.0+%, TCI America™
CAS: 22282-99-1 Molecular Formula: C6H6BrN Molecular Weight (g/mol): 172.03 MDL Number: MFCD03788196 InChI Key: JFBMFWHEXBLFCR-UHFFFAOYSA-N Synonym: 4-bromo-2-picoline,2-methyl-4-bromopyridine,4-bromo-2-methyl-pyridine,pyridine, 4-bromo-2-methyl,4-bromopicoline,zlchem 422,pubchem4035,acmc-209fui,4-bromo-methyl-pyridine PubChem CID: 2762835 IUPAC Name: 4-bromo-2-methylpyridine SMILES: CC1=CC(Br)=CC=N1
3-Bromo-4-methylpyridine 98.0+%, TCI America™
CAS: 3430-22-6 Molecular Formula: C6H6BrN Molecular Weight (g/mol): 172.025 InChI Key: GSQZOLXWFQQJHJ-UHFFFAOYSA-N Synonym: 3-bromo-4-picoline,4-methyl-3-bromopyridine,pyridine, 3-bromo-4-methyl,3-bromo-4-methyl-pyridine,3-brom-4-methylpyridin,zlchem 494,pubchem3994,3-bromo4-methylpyridine,3-bromo-4-methylpyridin PubChem CID: 817630 IUPAC Name: 3-bromo-4-methylpyridine SMILES: CC1=C(C=NC=C1)Br
2-Amino-4-chloropyridine 98.0+%, TCI America™
CAS: 19798-80-2 Molecular Formula: C5H6ClN2 Molecular Weight (g/mol): 129.57 MDL Number: MFCD04113820 InChI Key: RQMWVVBHJMUJNZ-UHFFFAOYSA-O Synonym: 2-amino-4-chloropyridine,4-chloro-pyridin-2-ylamine,2-pyridinamine, 4-chloro,4-chloro-2-pyridinamine,4-chloro-2-pyridylamine,2-amino-4-chloro pyridine,4-chloro-2-pyridinylamine,2-amino-4-chloro-pyridine,4-chloro-2-aminopyridine,4-chlorpyridin-2-amin PubChem CID: 581866 IUPAC Name: 2-amino-4-chloropyridin-1-ium SMILES: NC1=CC(Cl)=CC=[NH+]1
3-Amino-4-(trifluoromethyl)pyridine 98.0+%, TCI America™
CAS: 175204-80-5 Molecular Formula: C6H5F3N2 Molecular Weight (g/mol): 162.12 MDL Number: MFCD00173960 InChI Key: DROFUWWORPKKSI-UHFFFAOYSA-N Synonym: 3-amino-4-trifluoromethyl pyridine,4-trifluoromethyl pyridin-3-amine,3-amino-4-trifluoromethylpyridine,4-trifluoromethyl-pyridin-3-ylamine,3-pyridinamine, 4-trifluoromethyl,4-trifluoromethyl-3-pyridinamine,4-trifluoromethyl-3-pyridylamine,pubchem2987,acmc-209e9a,4-trifluoromethyl-3-pyridinylamine PubChem CID: 2735957 IUPAC Name: 4-(trifluoromethyl)pyridin-3-amine SMILES: NC1=C(C=CN=C1)C(F)(F)F
2,4-Pyridinedicarboxylic Acid 98.0+%, TCI America™
CAS: 499-80-9 Molecular Formula: C7H5NO4 Molecular Weight (g/mol): 167.12 MDL Number: MFCD00149413 InChI Key: MJIVRKPEXXHNJT-UHFFFAOYSA-N Synonym: 2,4-pyridinedicarboxylic acid,lutidinic acid,2,4-lutidinic acid,2,4-pyridinedicarboxylicacid, hydrate 1:1,4nrq,pd2,4-carboxypicolinic acid,pubchem16314,pyridine carboxylate, 6a,acmc-1bnb9 PubChem CID: 10365 ChEBI: CHEBI:44737 IUPAC Name: pyridine-2,4-dicarboxylic acid SMILES: OC(=O)C1=CC=NC(=C1)C(O)=O
4-Amino-2,6-dimethylpyridine 98.0+%, TCI America™
CAS: 3512-80-9 Molecular Formula: C7H10N2 Molecular Weight (g/mol): 122.171 MDL Number: MFCD00130078 InChI Key: ZJXMKPARTVOUAM-UHFFFAOYSA-N PubChem CID: 77047 IUPAC Name: 2,6-dimethylpyridin-4-amine SMILES: CC1=CC(=CC(=N1)C)N
Apexbio Technology LLC SCH772984 942183-80-4 50mg
SCH772984 (CAS 942183-80-4) is an ATP-competitive inhibitor targeting ERK1 and ERK2 kinases It demonstrates high inhibitory activity against these enzymes with reported IC50 values of 4 nmol/L for ERK1 and 1 nmol/L for ERK2 Although it shows characteristics typical of both type I and II kinase inhibitors selectivity screening against approximately 300 kinases identified significant inhibition in only a few additional kinases at concentrations exceeding 1 mol/L SCH772984 has been shown in vitro to inhibit proliferation of tumor cells harboring BRAF NRAS or KRAS mutations highlighting its applicability in research focused on ERK signaling
Apexbio Technology LLC SCH772984 942183-80-4 25mg
SCH772984 (CAS 942183-80-4) is an ATP-competitive inhibitor targeting ERK1 and ERK2 kinases It demonstrates high inhibitory activity against these enzymes with reported IC50 values of 4 nmol/L for ERK1 and 1 nmol/L for ERK2 Although it shows characteristics typical of both type I and II kinase inhibitors selectivity screening against approximately 300 kinases identified significant inhibition in only a few additional kinases at concentrations exceeding 1 mol/L SCH772984 has been shown in vitro to inhibit proliferation of tumor cells harboring BRAF NRAS or KRAS mutations highlighting its applicability in research focused on ERK signaling
Apexbio Technology LLC CARIPORIDE 159138-80-4 100mg
Cariporide (CAS 159138-80-4) is a potent and selective inhibitor of the Na /H exchanger isoform 1 (NHE1) exhibiting IC50 values of 0 05 M for NHE1 3 M for NHE3 and 1000 M for NHE2 By targeting NHE1 cariporide modulates ionic homeostasis implicated in the pathogenesis of myocardial ischemia-reperfusion injury In vitro cariporide concentration-dependently inhibits amiloride-sensitive sodium influx in rabbit erythrocytes and reduces platelet swelling induced by cellular acidification In vivo studies have demonstrated that both intravenous and oral administration in anesthetized rats attenuates or prevents ventricular arrhythmias following coronary ligation Cariporide has been explored in clinical trials related to acute coronary syndromes and is a valuable tool for cardiovascular research involving NHE1 modulation