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Filtered Search Results
Apexbio Technology LLC ACY-241 1316215-12-9 5mg
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ACY-241 (CAS 1316215-12-9) is a selective orally bioavailable inhibitor of histone deacetylase 6 (HDAC6) an enzyme that removes acetyl groups from -N-acetyl lysine residues on histones thus modulating chromatin structure and gene expression In preclinical studies ACY-241 demonstrated synergistic induction of apoptosis in multiple myeloma and mantle cell lymphoma cells when combined with immunomodulatory agents such as lenalidomide or pomalidomide accompanied by reduced MYC and IRF4 expression In solid tumor models co-administration with paclitaxel enhanced mitotic defects and led to dose-dependent hyperacetylation of -tubulin These findings support ACY-241 as a tool compound for investigating HDAC6 modulation in hematological and solid malignancies
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Medchemexpress LLC HY-15999 10mg Medchemexpress, Cerdulatinib CAS:1198300-79-6 Purity:>98%
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Medchemexpress, HY-15999 10mg Cerdulatinib CAS:1198300-79-6 Cerdulatinib (PRT062070) is a selective Tyk2 inhibitor with an IC50 of 0.5 nM. Cerdulatinib (PRT062070) also is a dual JAK and SYK inhibitor with IC50s of 12, 6, 8 and 32 for JAK1, 2, 3 and SYK, respectively. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC HY-15346 10mg Medchemexpress, Copanlisib CAS:1032568-63-0 Purity:>98%
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Medchemexpress, HY-15346 10mg Copanlisib CAS:1032568-63-0 Copanlisib (BAY 80-6946) is a potent, selective and ATP-competitive pan-class I PI3K inhibitor, with IC50s of 0.5 nM, 0.7 nM, 3.7 nM and 6.4 nM for PI3Kα, PI3Kδ, PI3Kβ and PI3Kγ, respectively. Copanlisib has more than 2,000-fold selectivity against other lipid and protein kinases, except for mTOR. Copanlisib has superior antitumor activity. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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eMolecules Medchem Express / Citarinostat / 5mg / 446267122 / HY-15994 / / 1316215-12-9 / MFCD28023593 / 467.950 / C24H26ClN5O3
Medchem Express / Citarinostat / 5mg / 446267122 / HY-15994 / / 1316215-12-9 / MFCD28023593 / 467.950 / C24H26ClN5O3
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eMolecules 2 4-DIMETHYL-5-PYRIMIDIN 0.25G
5000216512 2 4-DIMETHYL-5-PYRIMIDIN 0.25G
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eMolecules 7H-PYRROLO 2 3-D PYRIMIDIN 25G
5000217053 7H-PYRROLO 2 3-D PYRIMIDIN 25G
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Chemscene CHEMSCENE
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5000579899 7H-PYRROLO 2 3-D PYRIMIDIN- 5G
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![Medchemexpress LLC N-[4-[6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl]oxy-1,3-benzothiazol-2-yl]acetamide | 659730-32-2 | MFCD14584859 | 99.2% | 430.40 | C20H13F3N4O2S | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000244040.png-250.jpg)
Medchemexpress LLC N-[4-[6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl]oxy-1,3-benzothiazol-2-yl]acetamide | 659730-32-2 | MFCD14584859 | 99.2% | 430.40 | C20H13F3N4O2S | 25 MG
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AMG 517 is a potent, selective small-molecule antagonist of the vanilloid receptor TRPV1 for research use. It inhibits TRPV1-mediated calcium influx in cell-based and neuronal assays with low-nanomolar IC50 values, and is supplied as a high-purity solid suitable for pharmacology and biochemical studies.
- High purity solid suitable for in vitro research.
- Low-nanomolar TRPV1 potency (IC50 ≈ 0.5-0.9 nM).
- Molecular weight 430.40, formula C20H13F3N4O2S.
- Supplied with data sheet, certificate of analysis, and safety data sheet.
- Soluble in DMSO for preparation of stock solutions.
- Available in multiple pack sizes for flexibility in study scale.
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Medchemexpress LLC Urea, N-[4-[4-(4-morpholinyl)-6-(3-oxa-8-azabicyclo[3.2.1]oct-8-yl)-1,3,5-triazin-2-yl]phenyl]-N'-4-pyridinyl-, hydrochloride (1:1) | 1463510-35-1 | 99.66% | 525.00 | 1 MG
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PKI-179 hydrochloride is a potent and orally active dual PI3K/mTOR inhibitor. It exhibits anti-tumor activity in vivo, inhibiting tumor growth in nude mice bearing MDA-361 human breast cancer tumors. It also demonstrates good oral bioavailability and a high half-life.
- Potent and orally active dual PI3K/mTOR inhibitor
- Exhibits anti-tumor activity in vivo
- Inhibits cell proliferation with low IC50s
- Good oral bioavailability and high half-life
- Well tolerated in animal models
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eMolecules METHYL 1-HYDROXYMETHYLCYC 5G
5000215951 METHYL 1-HYDROXYMETHYLCYC 5G
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eMolecules 4-CHLORO-2-METHYL-PYRIMIDIN 5G
5000216321 4-CHLORO-2-METHYL-PYRIMIDIN 5G
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eMolecules ETHYL 2-4 4 5 5-TETRAMETH 25G
5000216424 ETHYL 2-4 4 5 5-TETRAMETH 25G
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Medchemexpress LLC Heptacosane | 593-49-7 | MFCD00009862 | 98.0% | 380.73 g/mol | C27H56 | 250 MG
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Heptacosane is a long-chain alkane (C27H56, MW 380.73 g/mol, CAS 593-49-7) supplied as a ≥98.0% analytical standard for research and chromatographic applications. It is intended as a reference compound for method development, calibration, and identification in GC/GC-MS and other analytical techniques. Follow the product SDS for handling and storage.
- High purity (98.0%) for analytical reliability.
- Straight-chain C27 hydrocarbon for reference standards.
- Suitable for GC and GC-MS method development and calibration.
- Provided in small quantities for laboratory use.
- Datasheet and SDS available for handling and safety information.
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000282330 4 5 6 7-TETRAHYDROBE 250MG
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000282763 BLUE DEXTRAN MW 200 250MG
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