Patiromer is an orally active, selective, and non-absorbable intestinal potassium (K+) polymer binder. It reversibly binds potassium ions in exchange for calcium (Ca2+), rapidly and continuously reducing serum potassium levels. It helps maintain a normal blood potassium state, reduces serum aldosterone levels, and increases fecal potassium excretion. Patiromer is mainly used in the study of hyperkalemia associated with conditions such as chronic kidney disease, diabetes, and heart failure, and is particularly suitable for improving renin-angiotensin-aldosterone system inhibitor (RAASi) therapy.
- Orally active
- Selective and non-absorbable intestinal potassium (K+) polymer binder
- Reversibly binds potassium ions in exchange for calcium (Ca2+)
- Increases fecal potassium excretion
- Sodium-free
- High-capacity potassium binding properties
- Poorly soluble in water (for in vivo preparation)