Pyrroles
Medchemexpress LLC Atorvastatin calcium salt trihydrate | 344423-98-9 | 99.8% | 605.71 | 1 G
Atorvastatin calcium salt trihydrate is a drug belonging to the statin class of drugs used to lower blood cholesterol levels. Atorvastatin calcium salt trihydrate has unique chemical properties that make it an effective tool in controlling high levels of low-density lipoprotein (LDL) cholesterol and triglycerides in the body, reducing the risk of heart attack and stroke. Atorvastatin calcium salt trihydrate works by inhibiting HMG-CoA reductase, the enzyme responsible for producing cholesterol in the liver.
- Lowers blood cholesterol levels.
- Controls high levels of low-density lipoprotein (LDL) cholesterol and triglycerides.
- Reduces the risk of heart attack and stroke.
- Works by inhibiting HMG-CoA reductase, the enzyme responsible for producing cholesterol in the liver.
- Can be used as a biochemical reagent for life science-related research.
Medchemexpress LLC 2-Acetylpyrrole | 1072-83-9 | 99.5% | 109.13 | 10 G
2-Acetylpyrrole is an organic compound featuring a pyrrole ring. It is a natural product of the Maillard browning reaction and is recognized as a significant flavor component in various foods. This compound also functions as an intermediate in the synthesis of other active compounds, such as the flavor compound 2-acetyl-1-pyrroline. For in vitro applications, 2-Acetylpyrrole reacts with nitrite to produce 1-nitro-2-acetylpyrrole (NAP) and 1,3,5-trinitro-2-acetylpyrrole (TNAP), which have demonstrated moderate mutagenicity and strong cytotoxicity.
- Organic compound with a pyrrole ring
- Product of Maillard browning reaction
- Major flavor component in many foods
- Intermediate in synthesis of other active compounds
- Suitable for research and analytical applications
- Reacts with nitrite to form nitropyrrole compounds
eMolecules Medchem Express | Ribociclib-d6 (hydrochloride) | 5mg | 632896553 | HY-15777AS | 477.04 | C23H31ClN8O
Medchem Express | Ribociclib-d6 (hydrochloride) | 5mg | 632896553 | HY-15777AS | | 477.040 | C23H31ClN8O
Medchemexpress LLC TAK-285 | 871026-44-7 | C26H25ClF3N5O3 | 100 MG
TAK-285 is a potent, selective, ATP-competitive, and orally active HER2 and EGFR (HER1) inhibitor. It demonstrates effective antitumor activity and can cross the blood-brain barrier (BBB). This compound exhibits significant growth inhibitory activity against BT-474 cells.
- Potent and selective HER2 and EGFR (HER1) inhibitor
- IC50 values of 17 nM for HER2 and 23 nM for EGFR (HER1)
- Shows over 10-fold selectivity for HER1/2 compared to HER4
- Less potent against MEK1/5, c-Met, Aurora B, Lck, and CSK
- Demonstrates effective antitumor activity
- Can cross the blood-brain barrier (BBB)
- Exhibits significant growth inhibitory activity against BT-474 cells with a GI50 of 17 nM
- Inhibits MEK1, MEK5, c-Met, Aurora B, Lck, CSK, and Lyn B with varying IC50s