Pyrroles
Medchemexpress LLC Olmesartan lactone impurity | 849206-43-5 | MFCD27978125 | 99.3% | 428.49 g/mol | C24H24N6O2 | 5 MG
Olmesartan lactone impurity is the cyclic ester impurity of olmesartan, provided as a high-purity analytical standard for research, impurity profiling, and method development. The compound has molecular formula C24H24N6O2 and molecular weight 428.49 g/mol, and is supplied in small-mass quantities for laboratory use.
- Reported purity 99.27% (rounded to 99.3%).
- Molecular formula C24H24N6O2; molecular weight 428.49 g/mol.
- Suitable as a reference standard for impurity profiling and analytical method development.
- Available in small pack sizes for analytical testing, such as 5 mg and 10 mg.
- Analytical documents available: data sheet, COA, HNMR, LCMS, and SDS.
Medchemexpress LLC (-)-Corey lactone diol | 32233-40-2 | 172.18 | 25 G
(-)-Corey lactone diol is the reduced form of Corey aldehyde. It can be used as a drug intermediate for the synthesis of Beraprost.
- Reduced form of Corey aldehyde
- Can be used as a drug intermediate
- Building block in chemical synthesis
Cayman Chemical RBromoenol lactone
A selective iPLA2γ inhibitor (IC50 = ~0.6 µM); selective for iPLA2γ over iPLA2β at 20-30 µM
Medchemexpress LLC Olmesartan lactone impurity | 849206-43-5 | MFCD27978125 | 99.3% | C24H24N6O2 | 10MG
Olmesartan lactone impurity is a cyclic ester impurity of olmesartan supplied as an analytical reference standard for impurity profiling, stability studies, and analytical method development. It is a white to off-white solid with high reported purity and specified storage conditions to support long-term stability.
- High purity: 99.27%.
- Molecular formula C24H24N6O2 and molecular weight 428.49 g·mol⁻¹.
- Available in small, measured quantities suitable for analytical use.
- Storage conditions provided for powder and solution to maintain integrity.
- Intended for impurity profiling, stability testing, and method validation.
Medchemexpress LLC (-)-G-Lactone | 43119-28-4 | >=98.0% | 124.14 | 250 MG
(-)-G-Lactone is a synthetic intermediate useful for prostaglandins synthesis. It is a drug intermediate. It appears as an off-white to light yellow solid.
- Synthetic intermediate for prostaglandins synthesis.
- Suitable for drug intermediate applications.
- Appears as an off-white to light yellow solid.
Apexbio Technology LLC Bromoenol lactone 88070-98-8 5mg
Bromoenol lactone (CAS 88070-98-8) is an irreversible inhibitor of cytosolic calcium-independent phospholipase A2 (iPLA2) an enzyme involved in the regulation of arachidonic acid release and lysophospholipid production iPLA2 activity is associated with phospholipid remodeling and the generation of signaling molecules that modulate processes such as eicosanoid synthesis insulin secretion apoptosis and cellular proliferation In cellular assays bromoenol lactone induces apoptosis in various cell lines and promotes proteolysis of procaspase-9 and procaspase-3 It also inhibits phosphatidic acid phosphohydrolase activity and disrupts triacylglycerol biosynthesis in macrophage models Bromoenol lactone is widely utilized in studies investigating lipid signaling cell death mechanisms and metabolic pathways
Medchemexpress LLC N-desethyl sunitinib | 356068-97-8 | 99.9% | 370.42 | 50 MG
N-Desethyl Sunitinib (SU-12662) is a metabolite of Sunitinib. It functions as a good transport substrate for human ABCB1, ABCG2, and murine ABCG2. This compound is provided as a solution in DMSO.
- Metabolite of sunitinib
- Acts as a good transport substrate for human ABCB1 and ABCG2
- Functions as a good transport substrate for murine ABCG2
- Provided in DMSO solution
TARGETMOL CHEMICALS INC Atorvastatin hemicalcium salt
Also available in 1 mL, 10 mg, 25 mg, 50 mg, 200 mg, 500 mg and bulk. Please contact Fisher for quotes. Atorvastatin hemicalcium salt (Atorvastatin Calcium) is an HMG-CoA reductase inhibitor with oral activity. Atorvastatin hemicalcium salt is used to lower cholesterol. Purity 99.89%
Selleck Chemical LLC Sacubitril hemicalcium salt S4426-100mg
Sacubitril (AHU-377) hemicalcium salt a component of the heart failure medicine LCZ696 is a potent inhibitor of neprilysin (neutral endopeptidase NEP)
Medchemexpress LLC HY-15816 10mg Medchemexpress, Ulixertinib CAS:869886-67-9 Purity:>98%
Medchemexpress, HY-15816 10mg Ulixertinib CAS:869886-67-9 Ulixertinib (BVD-523; VRT752271) is a potent, orally active, highly selective, ATP-competitive and reversible covalent inhibitor of ERK1/2 kinases, with an IC50 of <0.3 nM against ERK2. Ulixertinib (BVD-523; VRT752271) inhibits the phosphorylated ERK2 (pERK) and downstream kinase RSK (pRSK) in an A375 melanoma cell line[2]. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Cayman Chemical N-desethyl SunItInIb 500ug
An active metabolite of sunitinib; formed when sunitinib undergoes N-de-ethylation by CYP3A4; is pharmacologically active having similar inhibitory activity to sunitinib
Apexbio Technology LLC Sunitinib malate(Synonyms: Sutent, SU11248, Sunitinib L-malate, Sunitinib malate salt, SU-11248 malate, Sutent malate), 1g, CAS: 341031-54-7.
Sunitinib malate (CAS 341031-54-7) is a small molecule orally bioavailable multitargeted receptor tyrosine kinase inhibitor It inhibits various receptor tyrosine kinases including platelet-derived growth factor receptor (PDGFR) vascular endothelial growth factor receptors (VEGFR-1 2 and 3) c-KIT FLT3 kinase colony-stimulating factor-1 receptor (CSF-1R) and RET kinase In neuroblastoma cell lines (e g SK-N-BE(2) SH-SY5Y LAN-5) treatment with sunitinib malate significantly suppresses proliferation in a dose-dependent manner (IC50 10-20 ng/ml) Preclinical studies show tumor growth inhibition and reduced metastasis in neuroblastoma mouse models highlighting its potential for research in oncology therapeutics
Medchemexpress LLC PHA-767491 hydrochloride | 942425-68-5 | MFCD11519962 | 99.5% | 249.70 | C12H12ClN3O | 5 MG
PHA-767491 hydrochloride is a small-molecule research inhibitor that selectively targets Cdc7 and Cdk9 kinases. It is used in biochemical and cellular studies to probe DNA replication initiation, transcriptional regulation, and cancer cell proliferation. The compound exhibits low-nanomolar biochemical potency and measurable cellular activity, and is supplied as a high-purity solid for laboratory research.
- Potent dual Cdc7/Cdk9 inhibition with low-nanomolar IC50 values.
- Demonstrated cellular antiproliferative activity in multiple cancer cell lines.
- High purity suitable for biochemical and cellular assays.
- Solid, light yellow to yellow appearance for convenient handling.
- Stable under recommended storage conditions for research use.
- Analytical documentation available, including datasheet, COA, and SDS.
Apexbio Technology LLC AHU-377 hemicalcium salt 1369773-39-6 50mg
AHU-377 hemicalcium salt (CAS 1369773-39-6) is a hemicalcium salt form of AHU-377 a potent inhibitor of neprilysin (neutral endopeptidase) with an IC50 of 5 nM As a prodrug AHU-377 is enzymatically converted to its active metabolite LBQ657 following ester cleavage AHU-377 is a key component of LCZ696 co-formulated with valsartan at a 1 1 molar ratio functioning as an angiotensin receptor neprilysin inhibitor (ARNI) In vivo studies demonstrate that oral administration of AHU-377 induces dose-dependent blood pressure reduction in DAHI-SS rats though it has less pronounced effects in DOCA-salt hypertensive models AHU-377 is widely studied in cardiovascular research particularly in the context of heart failure and hypertension