Pyrroles
Medchemexpress LLC HY-15772 10mg Medchemexpress, Osimertinib CAS:1421373-65-0 Purity:>98%
Medchemexpress, HY-15772 10mg Osimertinib CAS:1421373-65-0 Osimertinib (AZD-9291) is an irreversible and mutant selective EGFR inhibitor with IC50s of 12 and 1 nM against EGFRL858R and EGFRL858R/T790M, respectively. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC HY-12861 10mg Medchemexpress, CB-5083 CAS:1542705-92-9 Purity:>98%
Medchemexpress, HY-12861 10mg CB-5083 CAS:1542705-92-9 CB-5083 is a potent, selective and orally bioavailable p97 inhibitor with an IC50 value of 11 nM. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
eMolecules 7152-42-3 | 10-Phenyl-10H-phenothiazine | Ambeed | MFCD00156238 | 275.370 | C18H13NS | 98.000 | S1c2ccccc2N(c2ccccc2)c2ccccc12 | 250mg | 521426398
10-Phenyl-10H-phenothiazine | Ambeed | 7152-42-3 | MFCD00156238 | 275.370 | C18H13NS | 98.000 | S1c2ccccc2N(c2ccccc2)c2ccccc12 | 250mg | 521426398
Medchemexpress LLC HY-12810 10mg Medchemexpress, EHop-016 CAS:1380432-32-5 Purity:>98%
Medchemexpress, HY-12810 10mg EHop-016 CAS:1380432-32-5 EHop-016 is a potent and selective Rac GTPase Rac1 and Rac3 inhibitor. EHop-016 inhibits Rac1 activity with an IC50 of 1.1 μM in MDA-MB-435 cells. EHop-016 inhibits Vav2 interaction with Rac, Rac-activated PAK1, lamellipodia formation, and cell migration. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Tlr7/8/9-in-1 | 2180127-82-4 | 98.5% | C27H37N3O2 | 10MG
TLR7/8/9-IN-1 is a potent, orally bioavailable small-molecule antagonist of Toll-like receptors 7, 8, and 9 intended for research use in immunology and inflammation studies. It inhibits TLR-mediated signaling in cellular assays and demonstrates low-nanomolar antagonist activity in PBMCs, supporting mechanistic and preclinical investigations.
- Potent antagonist with IC50 = 43 nM against TLR7/8/9.
- Low-nanomolar activity in PBMCs (TLR7 IC50 = 4.8 nM; TLR9 IC50 = 510 nM).
- Orally bioavailable small molecule suitable for in vivo and in vitro studies.
- High purity (98.51%) appropriate for biochemical assays.
- Available as solid and as 10 mM in DMSO solutions for flexible dosing.
Selleck Chemical LLC Ribociclib
Ribociclib is an orally available and highly specific inhibitor of CDK4 and CDK6 with IC50 of 10 nM and 39 nM Phase 3
eMolecules 677331-12-3 | Medchem Express | iCRT 14 | 5mg | 446267627 | HY-16665 | MFCD04366833 | 375.45 | C21H17N3O2S
Medchem Express | iCRT 14 | 5mg | 446267627 | HY-16665 | 677331-12-3 | MFCD04366833 | 375.450 | C21H17N3O2S
Medchemexpress LLC Compound 48/80 trihydrochloride | 848035-21-2 | 1 ML
Compound 48/80 trihydrochloride (C48/80 trihydrochloride) is a mixture of condensation products of N-methyl-p-methoxyphenethylamine with formaldehyde. It acts as a histamine releaser and a mast cell degranulator. This compound inhibits phosphatidylinositol-specific phospholipase C activity from human platelets, with IC50 values of 2.1 μg/ml (supernatant) and 5.0 μg/ml (particulate fraction). It also inhibits the aggregation of human platelets induced by ADP and PAF-acether.
- Acts as a histamine releaser and mast cell degranulator.
- Inhibits phosphatidylinositol-specific phospholipase C activity.
- Inhibits human platelet aggregation induced by ADP and PAF-acether.
- Increases serum serotonin, histamine, and corticosterone levels in vivo.
- Causes oxidative stress in rat adrenal glands through mast cell degranulation.
Medchemexpress LLC HY-15777 100mg , LEE011 Ribociclib CAS:1211441-98-3 Purity:98%
Medchemexpress, HY-15777 100mg LEE011 Ribociclib CAS:1211441-98-3 Formula:C23H30N8O IC50: 10/39 nM (CDK4/6) Purity:98% LEE011 is a highly specific CDK4/6 inhibitor with IC 50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex. Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.