Pyrroles
Medchemexpress LLC (6E)-3-bromo-4-(4-phenyl-1,2,3,4-tetrahydronaphthalen-1-ylidene)furan-2(5H)-one | 88070-98-8 | MFCD00270871 | 99.6% | 317.18 g/mol | C16H13BrO2 | 100 MG
Bromoenol lactone is an irreversible, suicide-based inhibitor of phospholipase A2 used as a research reagent to study lipid signaling, inflammation, and enzyme function. It is supplied as a white-to-yellow solid of high purity and is typically prepared in DMSO for in vitro and in vivo experiments. Powder storage at -20°C is recommended; solutions have limited stability.
- Irreversible, suicide-based inhibitor of phospholipase A2.
- High purity suitable for biochemical and pharmacological assays (≈99.6%).
- Molecular weight 317.18 g/mol; chemical formula C16H13BrO2.
- Soluble in DMSO (≈50 mg/mL); sonication recommended for dissolution.
- Powder stability at -20°C for up to 3 years; limited in-solution shelf life.
- Supplied as a solid to allow flexible formulation for in vitro and in vivo use.
TARGETMOL CHEMICALS INC ATORVASTATIN SODIUM 50MG
Also available in 10 mg 25 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Atorvastatin Sodium (Lipitor) is a competitive inhibitor of HMG-CoA reductase and increases the expression of low density lipoprotein (LDL) receptors on hepatocytes. Atorvastatin Sodium treatment inhibits aquaporin 4 to reduce ischaemic brain oedema. purity: 99%
Medchemexpress LLC HY-103704 5mg Medchemexpress, LY2562175 CAS:1103500-20-4 Purity:>98%
Medchemexpress, HY-103704 5mg LY2562175 CAS:1103500-20-4 LY2562175 is a potent and selective FXR agonist with an EC50 of 193 nM. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Selleck Chemical LLC Osimertinib
Osimertinib (AZD9291) is an oral irreversible and mutant-selective EGFR inhibitor with IC50 of 12 92 11 44 and 493 8 nM for Exon 19 deletion EGFR L858R/T790M EGFR and WT EGFR in LoVo cells respectively Phase 3
AdipoGen L-Homoserine lactone HCl
Chemical. CAS 2185-03-7. Formula C4H7NO2 . HCl. MW 137.56. L-Homoserine lactone is a synthetic building block or intermediate used in the synthesis of organoselenium chemistry intermediates and analogs of bacterial quorum-sensing signaling molecules.
Medchemexpress LLC RIPK1-IN-4 | 1481641-08-0 | 98.9% | 401.46 | C23H23N5O2 | 10 MG
A potent, selective type II kinase inhibitor of receptor-interacting protein 1 (RIP1) that binds the DLG-out inactive conformation. It exhibits low-nanomolar biochemical potency (RIP1 IC50 16 nM; ADP-Glo IC50 10 nM) and shows cellular activity against RIP1-mediated necroptosis, making it suitable as a research tool for studies of RIP1 signaling and necroptosis.
- Potent biochemical inhibition of RIP1 (IC50 16 nM).
- Low-nanomolar ADP-Glo kinase activity (IC50 10 nM).
- Cellular efficacy in necroptosis models (L929, U-937).
- High purity and white to off-white solid appearance.
- High DMSO solubility (250 mg/mL) with ultrasonic assistance.
- Stable when stored per recommended conditions (powder and solvent).
eMolecules 2-Amino-3-(1H-pyrrol-2-yl)-propionic acid | 3078-36-2 | MFCD09841939 | 5g
J & W PharmLab LLC | 2-Amino-3-(1H-pyrrol-2-yl)-propionic acid | 5g | 289355980 | 72R0014 | 95.000 | 3078-36-2 | MFCD09841939 | 154.169 | C7H10N2O2
If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link:
eMolecules Building Block Tool
Selleck Chemical LLC Varespladib (LY315920) S1110-5mg
Varespladib (LY315920) is a potent and selective human non-pancreatic secretory phospholipase A2 (hnsPLA) inhibitor with IC50 of 7 nM Phase 3
Apexbio Technology LLC AHU-377 hemicalcium salt 1369773-39-6 10mg
AHU-377 hemicalcium salt (CAS 1369773-39-6) is a hemicalcium salt form of AHU-377 a potent inhibitor of neprilysin (neutral endopeptidase) with an IC50 of 5 nM As a prodrug AHU-377 is enzymatically converted to its active metabolite LBQ657 following ester cleavage AHU-377 is a key component of LCZ696 co-formulated with valsartan at a 1 1 molar ratio functioning as an angiotensin receptor neprilysin inhibitor (ARNI) In vivo studies demonstrate that oral administration of AHU-377 induces dose-dependent blood pressure reduction in DAHI-SS rats though it has less pronounced effects in DOCA-salt hypertensive models AHU-377 is widely studied in cardiovascular research particularly in the context of heart failure and hypertension
Medchemexpress LLC Tlr7/8/9-in-1 | 2180127-82-4 | 98.5% | C27H37N3O2 | 10MG
TLR7/8/9-IN-1 is a potent, orally bioavailable small-molecule antagonist of Toll-like receptors 7, 8, and 9 intended for research use in immunology and inflammation studies. It inhibits TLR-mediated signaling in cellular assays and demonstrates low-nanomolar antagonist activity in PBMCs, supporting mechanistic and preclinical investigations.
- Potent antagonist with IC50 = 43 nM against TLR7/8/9.
- Low-nanomolar activity in PBMCs (TLR7 IC50 = 4.8 nM; TLR9 IC50 = 510 nM).
- Orally bioavailable small molecule suitable for in vivo and in vitro studies.
- High purity (98.51%) appropriate for biochemical assays.
- Available as solid and as 10 mM in DMSO solutions for flexible dosing.
Medchemexpress LLC 17-Phenyl trinor PGF 5mg | 130209-76-6 | 430.6 g/mol | C26H38O5 | 5 MG
Isopropyl ester derivative of 17-phenyl trinor prostaglandin F2α used as a research reagent in prostaglandin pharmacology. The compound acts as a potent FP receptor agonist and is supplied at high purity for in vitro and pharmacological studies.
- Isopropyl ester of 17-phenyl trinor PGF2α.
- Potent FP receptor agonist for prostaglandin research.
- High purity (≥98%).
- Molecular weight 430.6 g/mol; formula C26H38O5.
- Available in small research pack sizes such as 5 mg.
Medchemexpress LLC Kw-8232 | 217813-15-5 | 98.1% | 705.26 g·mol⁻¹ | C37H41ClN4O6S | 10 MG
KW-8232 is a small-molecule research compound reported as an orally active anti-osteoporotic agent that reduces prostaglandin E2 (PGE2) biosynthesis. It has been evaluated in preclinical bone-loss studies and has reported in vitro antiviral activity against SARS-CoV-2. Supplied for research use with supporting analytical documentation.
- Orally active anti-osteoporotic agent that reduces PGE2 biosynthesis.
- Reported in vitro antiviral activity against SARS-CoV-2 (EC50 ≈ 1.2 μM).
- High purity, 98.1%.
- Molecular weight 705.26 g·mol⁻¹; formula C37H41ClN4O6S.
- Soluble in DMSO at 125 mg/mL; ultrasonic assistance may be required.
- Available in multiple laboratory pack sizes and solution formats.
- Supplier documentation available: data sheet, certificate of analysis, and safety data sheet.
Medchemexpress LLC Jnj-18038683 | 851376-05-1 | 99.8% | 529.97 g/mol | C26H28ClN3O7 | 10 MG
This small-molecule research compound is a selective antagonist of the 5-hydroxytryptamine type 7 (5-HT7) receptor used in pharmacology and neuroscience studies. It shows high affinity in binding assays (pKi ≈ 8.19-8.20 for rat and human 5-HT7 in HEK293 cells), produces concentration-dependent inhibition of 5-HT-stimulated adenylyl cyclase, and alters REM sleep in rodent models. Supplied as a solid or as a DMSO solution for in vitro and in vivo research.
- Selective 5-HT7 receptor antagonist with high binding affinity.
- Demonstrated functional antagonism in adenylyl cyclase assays.
- Modulates REM sleep parameters in rodent studies.
- High purity suitable for research applications.
- Available as solid and ready-to-use DMSO solution.
- Store sealed and protect from moisture; follow supplier storage guidelines.
Chemscene ChemScene | tert-Butyl 4-(4-amino-2-fluorophenyl)tetrahydro-1(2H)-pyrazinecarboxylate | 10G | CS-M3008 | 0.98 | 154590-35-9| MFCD08443960 | 295.36
ChemScene | tert-Butyl 4-(4-amino-2-fluorophenyl)tetrahydro-1(2H)-pyrazinecarboxylate | 10G | CS-M3008 | 0.98 | 154590-35-9| MFCD08443960 | 295.36