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Filtered Search Results
Medchemexpress LLC 2-Pyridinamine, 5,6-bis(4-methoxy-3-methylphenyl)- | 2306039-66-5 | 99.8% | C21H22N2O2 | 100 MG
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WSB1 Degrader 1 is a potent and orally active WSB1 (WD repeat and SOCS box-containing 1) degrader, exhibiting anticancer metastatic effects.
- Induces WSB1 degradation in H1299-WSB1 cells.
- Exhibits potent antimigration efficacy in KHOS and H460 cell lines.
- Significantly inhibits cancer cell migration under normoxia and hypoxia in KHOS cells.
- Elevates RhoGDI2 protein levels in KHOS cells under hypoxia.
- Significantly inhibits wound-healing of H1299-WSB1 cells.
- Blocks wound-healing capability of wild-type A2780 cells.
- Effectively inhibits pulmonary metastasis of cancer cells in mice bearing highly metastatic 4T1 breast cancer cells.
- Shows quick absorption and acceptable blood exposure in rats after oral or intraperitoneal dosing.
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Medchemexpress LLC PROTAC CRBN Degrader-1 | 2358775-70-7 | 98.8% | 100 MG
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PROTAC CRBN Degrader-1 (Compound 14a) is a VHL-CRBN heterodimerization PROTAC degrader. It selectively degrades CRBN by binding two E3 ubiquitin ligases (VHL and CRBN) to each other. This compound consists of a VHL ligand, a CRBN ligand, and a linker, and is intended for research use only.
- Selectively degrades CRBN.
- Binds two E3 ubiquitin ligases (VHL and CRBN) to each other.
- Exhibits rapid degradation of CRBN (DC50=200 nM) in HeLa cells.
- Shows relatively weaker degrading activity against VHL proteins.
- Consists of a VHL ligand, a CRBN ligand, and a linker.
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Medchemexpress LLC (S,R,S)-AHPC-PEG5-COOH | 2172820-14-1 | 99.8% | 50 MG
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(S,R,S)-AHPC-PEG5-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 5-unit PEG linker used in PROTAC technology. It is for research use only.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates (S,R,S)-AHPC based VHL ligand
- Uses 5-unit PEG linker
- Utilized in PROTAC technology
- Recruits VHL protein, a substrate recognition subunit of E3 ubiquitin ligase complexes
- Induces ubiquitination and subsequent proteasomal degradation of target protein
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Medchemexpress LLC HY-101763A 500mg Medchemexpress, (S,R,S)-AHPC (hydrochloride) CAS:1448189-80-7 Purity:>98%
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Medchemexpress, HY-101763A 500mg (S,R,S)-AHPC (hydrochloride) CAS:1448189-80-7 (S,R,S)-AHPC hydrochloride is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC hydrochloride can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC S R S -AHPC-Me-C5-C | 100MG
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S R S -AHPC-Me-C5-C | 100MG
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eMolecules 904763-27-5 | Medchem Express | ATN-161 (trifluoroacetate salt) | 5mg | 446263078 | HY-13535A | MFCD28167827 | 711.67 | C25H36F3N9O10S
Medchem Express | ATN-161 (trifluoroacetate salt) | 5mg | 446263078 | HY-13535A | 904763-27-5 | MFCD28167827 | 711.670 | C25H36F3N9O10S
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Aobchem 1-(2-Bromobenzyl)pyrrolidine | ≥97% | CAS 91130-46-0 | C11H14BrN | 5g
1-(2-Bromobenzyl)pyrrolidine | ≥97% | CAS 91130-46-0 | C11H14BrN | 5g
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Aobchem 5-((Tert-Butoxycarbonyl)amino)-4-oxopentanoic acid | ≥95% | CAS 72072-06-1 | C10H17NO5 | 250mg
5-((Tert-Butoxycarbonyl)amino)-4-oxopentanoic acid | ≥95% | CAS 72072-06-1 | C10H17NO5 | 250mg
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Aobchem 5-((Tert-Butoxycarbonyl)amino)-4-oxopentanoic acid | ≥95% | CAS 72072-06-1 | C10H17NO5 | 5g
5-((Tert-Butoxycarbonyl)amino)-4-oxopentanoic acid | ≥95% | CAS 72072-06-1 | C10H17NO5 | 5g
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eMolecules 108787-91-3 | (S)-2-((tert-Butoxycarbonyl)amino)-5-((2,2,10,10-tetramethyl-4,8-dioxo-3,9-dioxa-5,7-diazaundecan-6-ylidene)amino)pentanoic acid | 250mg
Ambeed | 2-(Furan-2-yl)pyridin-4-amine | 100mg | 603088356 | A1077284 | 1159817-12-5 | MFCD12032854 | 160.176 | C9H8N2O
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Aobchem 4-(Pyrrolidine-1-carbonyl)phenylboronic acid | 97% | CAS 389621-81-2 | C11H14BNO3 | 100g
4-(Pyrrolidine-1-carbonyl)phenylboronic acid | 97% | CAS 389621-81-2 | C11H14BNO3 | 100g
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Aobchem 2-(N N- di-tert-butoxycarbonylamino) -3- fluoro -5- bromopyridine | 97% | CAS 2680539-48-2 | C15H20BrFN2O4 | 5g
2-(N N- di-tert-butoxycarbonylamino) -3- fluoro -5- bromopyridine | 97% | CAS 2680539-48-2 | C15H20BrFN2O4 | 5g
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Aobchem (3-Methoxy-4-(pyrrolidine-1-carbonyl)phenyl)boronic acid | 95% | CAS 1801923-34-1 | C12H16BNO4 | 250mg
(3-Methoxy-4-(pyrrolidine-1-carbonyl)phenyl)boronic acid | 95% | CAS 1801923-34-1 | C12H16BNO4 | 250mg
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Aobchem (3-Methoxy-4-(pyrrolidine-1-carbonyl)phenyl)boronic acid | 95% | CAS 1801923-34-1 | C12H16BNO4 | 5g
(3-Methoxy-4-(pyrrolidine-1-carbonyl)phenyl)boronic acid | 95% | CAS 1801923-34-1 | C12H16BNO4 | 5g
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Aobchem (5-((Tert-butoxycarbonyl)amino)-2-chlorophenyl)boronic acid | 97% | CAS 2246849-87-4 | C11H15BClNO4 | 500mg
(5-((Tert-butoxycarbonyl)amino)-2-chlorophenyl)boronic acid | 97% | CAS 2246849-87-4 | C11H15BClNO4 | 500mg
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