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Filtered Search Results
eMolecules 627530-84-1 | Medchem Express | BMS-564929 | 5mg | 446260748 | HY-12111 | MFCD15146692 | 305.72 | C14H12ClN3O3
Medchem Express | BMS-564929 | 5mg | 446260748 | HY-12111 | 627530-84-1 | MFCD15146692 | 305.720 | C14H12ClN3O3
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Medchemexpress LLC HY-12111 5mg Medchemexpress, BMS-564929 CAS:627530-84-1 Purity:>98%
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Medchemexpress, HY-12111 5mg BMS-564929 CAS:627530-84-1 BMS-564929 is an androgen receptor (AR) agonist, binds to androgen receptor (AR) with a Ki of 2.11±0.16 nM. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Selleck Chemical LLC Ombitasvir (ABT-267) S5403-5mg
Ombitasvir (ABT-267) is an inhibitor of the HCV non-structural protein 5A with antiviral activity
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![Strem, An Ascensus Company CAS 1402851-52-8. 50mg. 1-[(4S)-4-tert-Butyl-45-dihydro-2-oxazolyl]isoquinoline 98%.](https://assets.fishersci.com/TFS-Assets/CCG/product-images/VN00009818-07-1370.JPG-250.jpg)
Strem, An Ascensus Company CAS 1402851-52-8. 50mg. 1-[(4S)-4-tert-Butyl-45-dihydro-2-oxazolyl]isoquinoline 98%.
CAS 1402851-52-8. 50mg. 1-[(4S)-4-tert-Butyl-45-dihydro-2-oxazolyl]isoquinoline 98%. . Molecular Weight 254.3. Molecular Formula C16H18N2O. Color/form white-light yellow pwdr. Strem 07-1370. http//www.strem.com/catalog/v/07-1370/
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Medchemexpress LLC Milademetan | 1398568-47-2 | MFCD31692325 | 98.9% | 618.53 g/mol | C30H34Cl2FN5O4 | 1 MG
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Milademetan is a potent, orally active small-molecule inhibitor of the MDM2-p53 interaction used in preclinical oncology research. It restores p53 activity and induces G1 cell-cycle arrest, senescence, and apoptosis in p53 wild-type cancer models.
- Orally active MDM2-p53 inhibitor suitable for in vitro and in vivo research.
- Applicable to acute myeloid leukemia and various solid tumor studies.
- Induces G1 cell-cycle arrest, senescence, and apoptosis in p53 wild-type models.
- High reported purity for research use (≈98.9%).
- Well-characterized molecular properties (molecular weight 618.53 g/mol).
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Medchemexpress LLC (S,R,S)-AHPC-O-Ph-PEG1-NH2 | 2361117-24-8 | 97.0% | 50 MG
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(S,R,S)-AHPC-O-Ph-PEG1-NH2 is an E3 ligase ligand-linker conjugate that incorporates a VHL ligand for the E3 ubiquitin ligase and a PROTAC linker. It is utilized in PROTAC EED degrader-1 (HY-130614), which is a PROTAC targeting EED with a pKD of 9.02.
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Medchemexpress LLC PMX 205 Trifluoroacetate | 99.5% | 953.06 | 50 MG
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PMX 205 Trifluoroacetate | 99.5% | 953.06 | 50 MG
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Medchemexpress LLC (S,R,S)-AHPC-Me-C7 ester | 2639528-48-4 | 95.49% | 100 MG
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(S,R,S)-AHPC-Me-C7 ester is an E3 ligase ligand-linker conjugate utilized for synthesizing BCL-XL PROTAC degraders. This product is for research use only.
- Molecular weight: 614.80
- Formula: C32H46N4O6S
- Appearance: Solid
- Color: White to off-white
- Solubility: 6.67 mg/mL (10.85 mM) in DMSO
- Shipping: Room temperature in continental US
- Storage: -20°C, sealed, away from moisture; in solvent: -80°C for 6 months or -20°C for 1 month
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Medchemexpress LLC PROTAC MDM2 Degrader-1 | 2249944-98-5 | 98.1% | 10 MG
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PROTAC MDM2 Degrader-1 (Compound 15a) is an MDM2 PROTAC degrader. It blocks p53-MDM2 binding and degrades the target MDM2 protein by utilizing the E3 ligase function of MDM2 itself, thereby exerting an anti-tumor effect.
- Targets MDM2
- Inhibits MDM2 expression and promotes p53 expression in A549 cells
- Molecular weight: 1463.33
- Formula: C74H84Cl4N10O13
- Appearance: Solid
- Color: White to off-white
- Soluble in DMSO at 100 mg/mL (68.34 mM)
- Soluble in 10% DMSO and 90% Corn Oil (≥ 0.62 mg/mL)
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Medchemexpress LLC Phenol, 3-[[4-(2-pyridinyl)-2-thiazolyl]amino]- | 315702-75-1 | 99.95% | 50 MG
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KCC-07 is a potent and brain-penetrant MBD2 (methyl-CpG-binding domain protein 2) inhibitor. It prevents binding of MBD2 to methylated DNA and activates brain specific angiogenesis inhibitor 1 (BAI1), inducing anti-proliferative BAI1/p53/p21 signaling. It exhibits anticancer activity.
- Clearly inhibited medulloblastomas (MB) cell growth in vitro.
- Largely abrogated MBD2 binding to the ADGRB1 promoter in BAI1-silent MB cells.
- Treatment inhibited tumor growth and significantly extended the survival of MB xenografts in athymic nude mice.
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Medchemexpress LLC Pasireotide acetate | 396091-76-2 | 99.5% | 1107.26 | 1 MG
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Pasireotide acetate is a long-acting cyclohexapeptide somatostatin analogue. It enhances agonist activity at somatostatin receptors (subtypes sst1/2/3/4/5). This compound can suppress Growth Hormone (GH), Insulin-like Growth Factor-I (IGF-I), and Adrenocorticotropic Hormone (ACTH) secretion, indicating potential effectiveness in treating acromegaly and Cushing's disease.
- Enhances agonist activity at somatostatin receptors
- Suppresses GH, IGF-I, and ACTH secretion
- Exhibits antisecretory, antiproliferative, and proapoptotic activities
- Effectively inhibits GHRH-induced GH release in primary rat pituitary cells
- Decreases serum insulin and increases serum glucose in vivo
- Reduces tumor size and increases apoptosis in Pdx1-Cre mice
- Exerts antinociceptive and antiinflammatory actions via SSTR2 receptor
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Medchemexpress LLC PROTAC MDM2 Degrader-2 | 2249944-99-6 | 95.0% | 10 MG
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PROTAC MDM2 Degrader-2 is an MDM2 PROTAC degrader that induces the self-ubiquitination and degradation of MDM2, leading to the upregulation of p53 protein. It exhibits anti-tumor activity and is used in cancer research.
- Induces self-ubiquitination and degradation of MDM2
- Upregulates p53 protein
- Exhibits anti-tumor activity
- Used in cancer research
- Inhibits MDM2 protein in A549 cells
- Increases p53 in A549 cells
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Medchemexpress LLC BAY-298 | 2471978-97-7 | 100.0% | 100 MG
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BAY-298 is an orally active and selective luteinizing hormone receptor (LH-R) antagonist. It has IC50s of 96 nM for human LH (hLH), 23 nM for rat LH (rLH), and 78 nM for cynomolgus monkey LH (cLH). This compound is capable of reducing sex hormone levels and is intended for research use only.
- Orally active and selective luteinizing hormone receptor (LH-R) antagonist
- Capable of reducing sex hormone levels
- IC50 of 96 nM for human LH, 23 nM for rat LH, and 78 nM for cynomolgus monkey LH
- Solid appearance
- Off-white to light yellow color
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Medchemexpress LLC AZD5582 dihydrochloride | 1883545-51-4 | 99.8% | 1088.21 | 50 MG
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AZD5582 dihydrochloride is an antagonist of the inhibitor of apoptosis proteins (IAPs), binding to the BIR3 domains cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively. It induces apoptosis and is for research use only.
- Binds to BIR3 domains of cIAP1, cIAP2, and XIAP
- Induces apoptosis
- Inhibits cell viability in H1975 NSCLC cells
- Downregulates cIAP-1 and activates RIPK1
- Triggers extrinsic and intrinsic apoptosis pathways
- Causes degradation of cIAP1 and caspase 3 cleavage in tumor cells in vivo
- Leads to substantial tumor regressions in xenograft models
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Medchemexpress LLC (S,R,S)-AHPC-phenol-C4-NH2 dihydrochloride | 2376990-26-8 | 99.0% | 632.64 g/mol | C28H43Cl2N5O5S | 5 MG
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(S,R,S)-AHPC-phenol-C4-NH2 dihydrochloride is a von Hippel-Lindau (VHL) ligand building block used in PROTAC and E3 ligase chemistry. Supplied as a high-purity, research-scale solid, it is suitable for synthetic chemistry and ligand design workflows.
- VHL ligand used to recruit the von Hippel-Lindau protein.
- High reported purity (99.01%).
- White to off-white solid physical form.
- Available in small research-scale quantities, including 5 MG.
- Datasheet, certificate of analysis, and safety data sheet available for characterization and handling.
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