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Filtered Search Results
eMolecules Medchem Express / Grazoprevir / 5mg / 446265386 / HY-15298 / / 1350514-68-9 / MFCD25976700 / 766.910 / C38H50N6O9S
Medchem Express / Grazoprevir / 5mg / 446265386 / HY-15298 / / 1350514-68-9 / MFCD25976700 / 766.910 / C38H50N6O9S
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Medchemexpress LLC 1,2,4-trideoxy-4-(methylamino)-1-(4-pentylphenyl)-D-erythro-pent-1-enitol hydrochloride | 1072443-89-0 | >=98.0% | 313.86 g/mol | C17H27NO2.HCl | 10 MG
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SK1-I is a sphingosine analog and a selective, competitive inhibitor of sphingosine kinase 1 (SPHK1) with a reported Ki of approximately 10 μM. It is supplied for research use and is used in biochemical and cell-based studies to modulate sphingolipid signaling, enhance autophagy, and evaluate antitumor activity.
- Selective SPHK1 inhibitor (Ki ≈ 10 μM).
- Sphingosine analog used in biochemical and cellular assays.
- Reported to enhance autophagy and show antitumor effects in preclinical studies.
- Supplied in small milligram quantities for research use only.
- Common applications include pathway modulation, proliferation, and apoptosis studies.
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Medchemexpress LLC HY-100972 1mg Medchemexpress, ARV-771 CAS:1949837-12-0 Purity:>98%
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Medchemexpress, HY-100972 1mg ARV-771 CAS:1949837-12-0 ARV-771 is a potent BET degrader based on PROTAC technology with Kds of 34 nM, 4.7 nM, 8.3 nM, 7.6 nM, 9.6 nM, and 7.6 nM for BRD2(1), BRD2(2), BRD3(1), BRD3(2), BRD4(1), and BRD4(2), respectively. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC Neuraminidase-IN-1 | 2379438-80-7 | 98.9% | 317.25 | 50 MG
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Neuraminidase-IN-1 is a neuraminidase inhibitor with an IC50 of 0.21 μM. It exhibits excellent activity against the H1N1 influenza virus.
- Neuraminidase inhibitor
- Excellent activity against H1N1 influenza virus
- Good inhibitory effect on A/WSN/33H1N1 virus strains
- Low toxicity and good druggability
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eMolecules Medchem Express / A66 / 5mg / 446262599 / HY-13261 / / 1166227-08-2 / MFCD22378485 / 393.520 / C17H23N5O2S2
Medchem Express / A66 / 5mg / 446262599 / HY-13261 / / 1166227-08-2 / MFCD22378485 / 393.520 / C17H23N5O2S2
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Medchemexpress LLC HY-13534A 5mg Medchemexpress, Abarelix (Acetate) CAS: Purity:>98%
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Medchemexpress, HY-13534A 5mg Abarelix (Acetate) CAS: Abarelix Acetate (PPI 149 Acetate; R 3827 Acetate) is a potent gonadotrophin-releasing hormone (GnRH) antagonist, used for prostate cancer research. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC Vh-298 10Mg | HY-100947-10MG
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Vh-298 10Mg
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Medchemexpress LLC (S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH | 2086301-47-3 | 99.31% | 50 MG
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(S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH is an E3 ligase ligand-linker conjugate that incorporates a VHL ligand on one end. It is utilized in PROTAC (Proteolysis Targeting Chimeras) technology. PROTACs function by connecting a ligand for an E3 ubiquitin ligase with a ligand for a target protein via a linker, leveraging the intracellular ubiquitin-proteasome system to facilitate selective degradation of target proteins.
- E3 ligase ligand-linker conjugate
- Contains a VHL ligand
- Used in PROTAC technology
- Leverages the ubiquitin-proteasome system
- Facilitates selective degradation of target proteins
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Medchemexpress LLC Pasireotide acetate | 396091-76-2 | 99.5% | 1107.26 | 50 MG
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Pasireotide acetate is a long-acting cyclohexapeptide somatostatin analogue that improves agonist activity at somatostatin receptors. It can suppress GH, IGF-I, and ACTH secretion, indicating potential efficacy in acromegaly and Cushing's disease. This compound also exhibits antisecretory, antiproliferative, and proapoptotic activity.
- Improves agonist activity at somatostatin receptors (subtypes sst1/2/3/4/5, pKi=8.2/9.0/9.1/<7.0/9.9, respectively).
- Suppresses GH, IGF-I, and ACTH secretion, indicating potential efficacy in acromegaly and Cushing's disease.
- Exhibits antisecretory, antiproliferative, and proapoptotic activity.
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Medchemexpress LLC Taltirelin acetate (TA-0910 acetate) | 1549593-23-8 | 99.4% | 50 MG
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Taltirelin acetate (TA-0910 acetate) is an acetate form of Taltirelin (TA-0910), an orally effective analogue of thyrotropin releasing hormone (TRH) and a TRH receptor (TRH-R) superagonist. This compound can cross the blood-brain barrier and stimulates an increase in cytosolic Ca2+ concentration.
- Orally effective analogue of thyrotropin releasing hormone (TRH)
- TRH receptor (TRH-R) superagonist
- Can cross the blood-brain barrier
- Stimulates an increase in cytosolic Ca2+ concentration (Ca2+ release)
- Increases cell viability and reduces apoptosis in SH-SY5Y cells and primary rat mesencephalic neurons
- Demonstrates neuroprotective effects in cellular and animal models of Parkinson's disease
- Alleviates fatigue-like behavior in mouse models of cancer-related fatigue
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Medchemexpress LLC Protac SGK3 degrader-1 | 2381320-35-8 | 99.9% | 1157.38 g/mol | C57H73FN10O11S2 | 1MG
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PROTAC SGK3 degrader-1 is a VHL-ligand-based PROTAC chemical probe developed to induce proteasomal degradation of SGK3 in cellular systems. It exhibits rapid, concentration-dependent activity and is supplied as a high-purity research reagent.
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Medchemexpress LLC Cgp-42112 (Cgp-42112A) | 127060-75-7 | MFCD00133611 | 99.8% | 1052.19 g·mol-1 | C52H69N13O11 | 1MG
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CGP-42112 (CGP-42112A) is a peptide-like research compound that acts as a potent angiotensin II subtype 2 (AT2) receptor agonist. It is supplied for research use only and is available as solid material and as a DMSO solution. The product has a defined purity, molecular weight, solubility profile, and recommended storage conditions, making it suitable for in vitro assays and for formulation in common in vivo vehicles.
- Potent angiotensin II subtype 2 receptor agonist.
- High purity (99.84%).
- Molecular weight 1052.19 g·mol-1.
- Soluble in DMSO (100 mg/mL); compatible with common in vivo vehicles.
- Supplied as solid and as DMSO solution in multiple pack sizes.
- Powder stable at -20 °C for long-term storage; solutions stable at -80 °C.
- For research use only.
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Apexbio Technology LLC GDC-0152 873652-48-3 10mg
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GDC-0152 (CAS 873652-48-3) is a small-molecule antagonist of inhibitor of apoptosis proteins (IAPs) including ML-IAP XIAP cIAP1 and cIAP2 It binds to the BIR domain of ML-IAP and the BIR3 domains of XIAP cIAP1 and cIAP2 with reported Ki values of 14 nM 28 nM 17 nM and 43 nM respectively GDC-0152 promotes degradation of cIAP1 and induces caspase-3/7 activation resulting in reduced viability of breast cancer cells while sparing normal epithelial cells In cellular models GDC-0152 disrupts interactions between XIAP and caspase-9 and between IAPs and Smac supporting its utility in apoptosis-related cancer research
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Medchemexpress LLC Terlipressin diacetate | 1884420-36-3 | 99.8% | 1347.48 | C56H82N16O19S2 | 100MG
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Terlipressin diacetate is a vasopressin analogue and a selective vasopressin V1 receptor agonist used in research to reduce splanchnic blood flow and portal pressure. It is applied in studies of acute variceal bleeding, hepatorenal syndrome, and norepinephrine-resistant septic shock, and shows anti-inflammatory and anti-oxidative effects. Supplied as a purified peptide with recommended frozen storage to preserve stability.
- High purity suitable for research applications.
- Selective vasopressin V1 receptor agonist activity.
- Relevant for models of portal hypertension and variceal bleeding.
- Exhibits anti-inflammatory and anti-oxidative properties.
- Storage recommendations minimize degradation and extend shelf life.
- Available in multiple pack sizes for flexible experimental needs.
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Medchemexpress LLC Act-462206 | 1361321-96-1 | MFCD28502270 | 99.5% | 388.48 | C20H24N2O4S | 25 MG
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ACT-462206 is an orally active, brain-penetrant dual orexin (OX1/OX2) receptor antagonist used in neuroscience research into sleep, anxiety, and addiction. The compound shows low-nanomolar activity at orexin receptors and is supplied as a high-purity solid or solution format for laboratory use (research use only).
- Dual orexin receptor antagonist with low-nanomolar potency (OX1 and OX2)
- Brain-penetrant properties suitable for CNS pharmacology studies
- High purity (~99.5%) for reliable biochemical and pharmacological testing
- Soluble in DMSO at ≥100 mg/mL for in vitro preparations
- Available in research-scale solid and solution formats
- Stored and shipped under recommended conditions to preserve stability
- For research use only, not for human or clinical use
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