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Filtered Search Results
Apexbio Technology LLC SU 9516 377090-84-1 10mg
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SU 9516 (CAS 377090-84-1) is a potent and selective inhibitor of cyclin-dependent kinase 2 (CDK2) with an IC50 of 22 nM It exhibits markedly reduced activity against CDK1 CDK4 PKC p38 and PDGFR SU 9516 disrupts cell cycle progression by inhibiting CDK2-mediated phosphorylation of the retinoblastoma protein (pRb) and induces cell cycle arrest and apoptosis in various cancer cell lines including colon carcinoma and leukemia It has been shown to reduce levels of Cyclin D1 and CDK2 promote mitochondrial translocation of Bax cytochrome c release and activate caspase cascades SU 9516 serves as a valuable chemical probe for investigating CDK2 function and cell cycle regulation in cancer research
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Medchemexpress LLC Gdc-0152 Per 10.0 Mg.873652-48 | HY-13638-10MG
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Gdc-0152 Per 10.0 Mg.873652-48
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Medchemexpress LLC Bisindolylmaleimide V | 113963-68-1 | 97.8% | 341.36 | 50 MG
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Bisindolylmaleimide V is a cell-permeable negative control for protein kinase C inhibition studies, with an IC50 value exceeding 100 μM. It blocks the activation of mitogen-stimulated protein kinase p70s6k/p85s6k (S6K) in vivo, with an IC50 of 8 μM. This product is for research use only.
- Cell-permeable negative control for protein kinase C inhibition studies
- Blocks activation of mitogen-stimulated protein kinase p70s6k/p85s6k (S6K) in vivo
- Appears as a solid with an orange to red color
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Medchemexpress LLC Z-LEHD-FMK | 210345-04-3 | 98.1% | 690.72 | 50 MG
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Z-LEHD-FMK is a selective and irreversible inhibitor of caspase-9. It protects against lethal reperfusion injury, attenuates apoptosis, and demonstrates neuroprotective effects in a rat model of spinal cord trauma. This compound is a potent tool for research into apoptosis and neuroprotection.
- Selective and irreversible inhibitor of caspase-9
- Protects against lethal reperfusion injury
- Attenuates apoptosis
- Neuroprotective effect in spinal cord trauma models
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Medchemexpress LLC Z-IETD-AFC | 219138-02-0 | 99.7% | 821.75 | 1 MG
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Z-IETD-AFC is a specific fluorescence substrate utilized to determine caspase-8 catalytic activity. This product is intended for research use only.
- Specific fluorescence substrate for caspase-8.
- Can be used to determine caspase-8 catalytic activity.
- High purity (99.74%).
- Store sealed, away from moisture and light, under nitrogen.
- Powder storage: -80°C for 2 years or -20°C for 1 year.
- Storage in solvent: -80°C for 6 months or -20°C for 1 month (sealed, away from moisture and light, under nitrogen).
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TARGETMOL CHEMICALS INC N-Ethylmaleimide 500MG
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Also available in 1 g, 1 mL, 10 mg, 25 mg, 100 mg, 200 mg and bulk. Please contact Fisher for quotes. N-Ethylmaleimide (NEM) is a reagent for alkylation of free sulfhydryl groups, a cysteine protease inhibitor used in experimental biochemistry. N-Ethylmaleimide is also a deubiquitinating enzyme inhibitor that specifically inhibits phosphate transport in mitochondria. Purity 99.92%
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Medchemexpress LLC Felypressin acetate | 914453-97-7 | MFCD16652603 | 99.6% | C46H65N13O11S2.xC2H4O2 | 50 MG
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Felypressin acetate is a non-catecholamine vasoconstrictor and a vasopressin 1 agonist. It is widely used in dental procedures.
- Non-catecholamine vasoconstrictor: It constricts blood vessels without containing catecholamine.
- Vasopressin 1 agonist: It activates vasopressin 1 receptors.
- Dental procedures: It is widely used in dentistry, and can reduce toxicity during these procedures.
- Mediated by V1 receptors: Its vasoconstrictor action is mediated by V1 receptors of blood vessel smooth muscle cells.
- Increases diastolic blood pressure: It can increase the diastolic blood pressure of hypertensive patients with controlled blood pressure.
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000430593 2S 3S -3-AMINO-N-CY 100MG
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Medchemexpress LLC Lurasidone | 367514-87-2 | 99.4% | C28H36N4O2S | 500 MG
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Lurasidone is an antagonist of both dopamine D2 and 5-HT7 receptors with IC50s of 1.68 nM and 0.495 nM, respectively. It is also a partial agonist of the 5-HT1A receptor with an IC50 of 6.75 nM.
- Antagonizes dopamine D2 and 5-HT7 receptors.
- Acts as a partial agonist of the 5-HT1A receptor.
- Exhibits higher affinity for dopamine D2 and 5-HT2A receptors.
- Inhibits dopamine-stimulated [35S]GTPγS binding.
- Increases DOPAC/dopamine ratio in frontal cortex and striatum.
- Comparable potency to olanzapine in inhibiting conditioned avoidance response.
- Inhibits tryptamine-induced forepaw clonic seizure and p-chloroamphetamine-induced hyperthermia.
- Increases shocks received by rats in conflict test.
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Medchemexpress LLC Felypressin acetate (PLV-2 acetate) | 914453-97-7 | 99.60% | C46H65N13O11S2.xC2H4O2 | 5 MG
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Felypressin acetate (PLV-2 acetate) is a non-catecholamine vasoconstrictor and a vasopressin 1 agonist. It is widely used in dental procedures. Its vasoconstrictor action is believed to be mediated by V1 receptors in the smooth muscle cells of blood vessels.
- Acts as a non-catecholamine vasoconstrictor
- Functions as a vasopressin 1 agonist
- Widely used in dental procedures
- Helps reduce toxicity during dental procedures
- Can increase diastolic blood pressure in hypertensive patients with controlled blood pressure
- Synthetic hormone with vasoconstrictor properties
- Mediates vasoconstrictor action via V1 receptors
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Medchemexpress LLC 6-(4-(5-(3,5-Difluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbonyl)piperidin-1-yl)pyrimidine-4-carbonitrile | 99.9% | 396.39 | 1 ML
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(Rac)-GSK547 is the racemate of GSK547, a highly selective and potent inhibitor of receptor-interacting serine/threonine protein kinase 1 (RIP1). It inhibits macrophage-mediated adaptive immune tolerance in pancreatic cancer.
- Highly selective and potent inhibitor of receptor-interacting serine/threonine protein kinase 1 (RIP1)
- Inhibits macrophage-mediated adaptive immune tolerance in pancreatic cancer
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Medchemexpress LLC (2S,3S)-2-(Benzyl(methyl)amino)-3-methylpentanoic acid | 4125-97-7 | 99.2% | C14H21NO2 | 1 G
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(2S,3S)-2-(Benzyl(methyl)amino)-3-methylpentanoic acid is an isoleucine derivative. Amino acids and amino acid derivatives have been commercially used as ergogenic supplements. They influence the secretion of anabolic hormones, supply of fuel during exercise, mental performance during stress related tasks and prevent exercise induced muscle damage. They are recognized to be beneficial as ergogenic dietary substances.
- Is an isoleucine derivative
- Used as ergogenic supplements
- Influences the secretion of anabolic hormones
- Supplies fuel during exercise
- Aids mental performance during stress-related tasks
- Helps prevent exercise-induced muscle damage
- Beneficial as an ergogenic dietary substance
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eMolecules Di-tert-butyl 2,2'-((2-cyanoacetyl)azanediyl)diacetate | 1209379-68-9 | | 1g
Synthonix - Stock | Di-tert-butyl 2,2'-((2-cyanoacetyl)azanediyl)diacetate | 1g | 495876601 | D62289 | | 1209379-68-9 | | 312.366 | C15H24N2O5
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Medchemexpress LLC (S,S,S,S,R)-Boc-Dap-NE | 3026594-75-9 | C23H36N2O5 | 50 MG
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This product is identified as (S,S,S,S,R)-Boc-Dap-NE. Its relevant uses include laboratory chemicals and the manufacture of substances. Chemically, it has a molecular formula of C23H36N2O5 and a molecular weight of 420.54. The product appears as a solid and has a relative density of 1.125±0.06g/cm³. According to hazard identification, this substance is classified as acutely toxic, causing skin and serious eye irritation, and respiratory tract irritation. It carries a "Warning" signal word with hazard statements such as "Harmful if swallowed," "Causes skin irritation," "Causes serious eye irritation," and "May cause respiratory irritation."
- Identified for use as laboratory chemicals
- Suitable for the manufacture of substances
- Appears as a solid
- Relative density of 1.125±0.06g/cm³
- Classified as acutely toxic
- Causes skin and serious eye irritation
- May cause respiratory tract irritation
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![eMolecules 2-Bromo-7-(tert-butoxycarbonyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-3-carboxylic acid | 1823840-73-8 | MFCD27939610 | 1g](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502168013.JPG-250.jpg)
eMolecules 2-Bromo-7-(tert-butoxycarbonyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-3-carboxylic acid | 1823840-73-8 | MFCD27939610 | 1g
Synthonix - Stock | 2-Bromo-7-(tert-butoxycarbonyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-3-carboxylic acid | 1g | 495875002 | B69701 | | 1823840-73-8 | MFCD27939610 | 346.181 | C12H16BrN3O4
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