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Filtered Search Results
Medchemexpress LLC (Rac)-JBJ-04-125-02 acetate | 00-00-0 | MFCD32709390; MFCD16606534 | 98.7% | 543.61 g/mol | C29H26FN5O3S | 5 MG
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(Rac)-JBJ-04-125-02 acetate is the racemic acetate salt of a research-grade allosteric EGFR inhibitor. It is a potent, mutant-selective, orally active compound with reported sub-nanomolar biochemical potency against the L858R/T790M EGFR variant and demonstrated single-agent activity in cellular and animal models. Supplied as a white to off-white solid for laboratory research use only.
- Potent, mutant-selective EGFR inhibition with sub-nanomolar biochemical potency.
- Demonstrated single-agent activity in both in vitro and in vivo models.
- Allosteric mode of action complementary to ATP-site inhibitors.
- Available as a racemic acetate solid suitable for assay and formulation work.
- Provided with documentation such as COA, HPLC, and NMR upon request.
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Ambeed AMBEED
5000889356 MALEIMIDE-PEG8-SUCCINIMI 250MG
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Medchemexpress LLC Bisindolylmaleimide I hydrochloride | 176504-36-2 | 98.4% | 448.94 | 100 MG
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Bisindolylmaleimide I hydrochloride is a cell-permeable and reversible protein kinase C (PKC) inhibitor with IC50 values of 20 nM, 17 nM, 16 nM, and 20 nM for PKCα, PKCβI, PKCβII, and PKCγ, respectively. It also acts as a glycogen synthase kinase-3 (GSK-3) inhibitor, making it suitable for a wide range of research applications.
- Cell-permeable and reversible protein kinase C inhibitor
- Glycogen synthase kinase-3 inhibitor
- Inhibits α-thrombin-induced P47 phosphorylation
- Inhibits DNA synthesis in quiescent swiss 3T3 cells
- Reduces GSK-3 activity in adipocyte lysates
- Inhibits exosome and microvesicle release from PC3 cells
- Enhances cytotoxicity of 5-fluorouracil
- Reduces increased NLRP3, P-PKCɑ, and PKCɑ levels in mechanical ventilation group
- Reduces Quinpirole-induced vomiting in shrews
- Blocks Quinpirole-mediated ERK1/2 phosphorylation in shrew brainstems
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Broadpharm BROADPHARM
NC3920987 DBCO-MALEIMIDE 100MG
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Aobchem AOBCHEM
5000936146 1- 2 5-DIETHYLPHENYL CYCLOBUTA
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Aobchem AOBCHEM
5000946090 1- 4-CHLORO-3 5-DIETHYLPHENYL
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eMolecules 541-59-3 | Maleimide | Apollo Scientific US - Building Blocks | MFCD00005494 | 97.073 | C4H3NO2 | 95.000 | O=C1NC(=O)C=C1 | 25g | 398000270
Maleimide | Apollo Scientific US - Building Blocks | 541-59-3 | MFCD00005494 | 97.073 | C4H3NO2 | 95.000 | O=C1NC(=O)C=C1 | 25g | 398000270
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Medchemexpress LLC BCN-endo-PEG7-maleim |5mg
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BCN-endo-PEG7-maleimide is an ADC Linker containing 7 PEG units BCN-endo-PEG7-maleimide contains the lyophilic bidentate macrocyclic ligand endo-BCN which can further synthesize macrocyclic complexes In click chemistry endo-BCN can react with molecules containing azide groups to form stable triazoles in the absence of catalysts
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Aobchem AOBCHEM
5000996031 ETHYL 2- 2 5-DIETHYLPHENYL -2-
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Aobchem AOBCHEM
5000996032 ETHYL 2- 2 5-DIETHYLPHENYL -2-
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Aobchem AOBCHEM
5001014609 1- 2 4-DIETHYLPHENYL CYCLOBUTA
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Aobchem AOBCHEM
5001015299 1- 2 5-DIETHYLPHENYL -2 2-DIFL
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Lumiprobe SULFO-CYANINE3 MALEIMIDE 25 MG
NC3852129 SULFO-CYANINE3 MALEIMIDE 25 MG
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Chemscene ChemScene | Amino-PEG4-Val-Cit-PAB-MMAE | 5MG | CS-0114459 | 0.98 | 1492056-71-9| | 1370.71
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ChemScene | Amino-PEG4-Val-Cit-PAB-MMAE | 5MG | CS-0114459 | 0.98 | 1492056-71-9| | 1370.71
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000370895 TCO4-PEG7-MALEIMIDE 25MG
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