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Filtered Search Results
Selleck Chemical LLC Rolipram ZK-62711-10mg
The PDE4 selective inhibitor, Rolipram (ZK-62711, SB 95952), inhibited immunopurified PDE4B and PDE4D activities similarly, with IC50 values of approx. 130 nM and 240 nM respectively; an anti-inflammatory agent.
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Sigma Aldrich Fine Chemicals Biosciences N-(Allyloxycarbonyloxy)succinimide 96% | 135544-68-2 | MFCD02684388 | 5G
N-(Allyloxycarbonyloxy)succinimide 96% | Purity: 96% | Mol Wt: 199.16 | 135544-68-2 | MFCD02684388 | 5G
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Apexbio Technology LLC GW311616 hydrochloride 197890-44-1 5mg
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GW311616 hydrochloride (CAS 197890-44-1) is a selective cell-permeable inhibitor of human neutrophil elastase (HNE) exhibiting an IC50 of 22 nM and a Ki of 0 13 nM in enzymatic assays It demonstrates pronounced selectivity with IC50 values exceeding 100 M for trypsin cathepsin G and plasmin and greater than 3 M for chymotrypsin and tissue plasminogen activator In human whole blood assays GW311616 hydrochloride achieves an IC50 of 0 67 M The compound is orally bioavailable and displays prolonged activity in dog blood samples indicating a sustained inhibitory effect on neutrophil elastase GW311616 hydrochloride is valuable for investigating HNE s role in inflammation and related pathologies
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![eMolecules 2-AZABICYCLO[2.2.1]HEPTANE-2-CARBOXYLIC ACID, 5-AMINO-, 1,1-DIMETHYLETHYL ESTER | 207405-62-7 | | 1g](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502172000.JPG-250.jpg)
eMolecules 2-AZABICYCLO[2.2.1]HEPTANE-2-CARBOXYLIC ACID, 5-AMINO-, 1,1-DIMETHYLETHYL ESTER | 207405-62-7 | | 1g
AstaTech | 2-AZABICYCLO[2.2.1]HEPTANE-2-CARBOXYLIC ACID, 5-AMINO-, 1,1-DIMETHYLETHYL ESTER | 1g | 385237430 | P17101 | 95.000 | 207405-62-7 | | 212.293 | C11H20N2O2
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Chem-Impex International, Inc. N-Vinyl-2-pyrrolidone | MFCD00003197 | 1KG
N-Vinyl-2-pyrrolidone, MFCD00003197, 1KG
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Medchemexpress LLC 4-(Hydroxymethyl)phenylacetic acid | 73401-74-8 | 166.18 | 10 G
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4-(Hydroxymethyl)phenylacetic acid (4HMPAA) is a compound that functions as the primary structural component for insoluble polypeptides. It can participate in chemical reactions with DEPBT and 4-acetylaniline to generate amide intermediates. This compound is also recognized as a metabolite resulting from the breakdown of flavonoids, like quercetin, by colonic microbiota. Furthermore, 4HMPAA significantly inhibits 6-MP oxidation, demonstrating a selective inhibitory action as it does not considerably affect xanthine oxidation.
- Functions as the main body of insoluble polypeptides.
- Reacts with DEPBT and 4-acetylaniline to form amide intermediates.
- A metabolite derived from the metabolism of flavonoids such as quercetin by colonic microbiota.
- Exhibits significant inhibition of 6-MP oxidation.
- Shows no significant inhibition on xanthine oxidation.
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Medchemexpress LLC Glucovanillin | 494-08-6 | 5 MG
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Glucovanillin, found in vanilla, is a potential lipase inhibitor. It can be converted into vanillin through an enzyme-coupled process involving cell wall degradation and glucovanillin hydrolysis. It has the potential to inhibit the lipase activity of *Acinetobacter radioresistens*.
- Potential lipase inhibitor
- Purity 99.87%
- Available in solid and solution forms
- For research use only
- Targets lipase
- Functions via metabolic enzyme/protease pathway
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Medchemexpress LLC Rac cotinine-d4 | 350818-68-7 | 99.6% | 180.24 | C10H8D4N2O | 10 MG
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(Rac)-Cotinine-d4 is the deuterium-labeled racemic form of cotinine intended for use as an analytical tracer and internal standard in quantitative assays (LC-MS, GC-MS, and NMR). It is supplied in small milligram quantities for research and method development.
- Deuterium-labeled racemic cotinine (d4) for use as an internal standard.
- Suitable for LC-MS, GC-MS, and NMR quantitation.
- High purity (~99.6%) to minimize interference in analytical assays.
- Provided in small, ready-to-use milligram quantities for analytical workflows.
- Stable when stored under recommended temperature conditions for reliable performance.
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Medchemexpress LLC 5-Hydroxymethyl-2'-deoxyuridine | 5116-24-5 | 99.9% | 25 MG
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5-Hydroxymethyl-2'-deoxyuridine is a nucleoside analog that inhibits the replication of various human leukemia cell lines with IC50 values between 1.7 and 5.8 μM. It has also been shown to prolong the survival of mice with L1210 leukemia. This compound is suitable for research concerning cell replication and leukemia. It has a molecular weight of 258.23 and a chemical formula of C10H14N2O6, appearing as a white to off-white solid.
- Inhibits replication of multiple human leukemia cell lines
- Prolongs survival of mice carrying L1210 leukemia
- Inhibits replication of Sarcoma 180 cells and Ehrlich ascites carcinoma cells
- Inhibits herpes simplex virus type 1 (HSV-1) pyrimidine 2'-deoxyribonucleoside kinase
- Shows dose-dependent toxicity against human acute promyelocytic leukemia cell line
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Medchemexpress LLC 1-(2,5-dioxopyrrolidin-1-yl)oxy-1-oxo-4-(pyridin-2-yldisulfanyl)butane-2-sulfonic acid | 1193111-39-5 | MFCD20227457 | 92.1% | 406.45 | C13H14N2O7S3 | 25 MG
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sulfo-SPDB is a cleavable antibody-drug conjugate (ADC) linker featuring a pyridyldisulfide-based disulfide that is reductively cleavable and a sulfonic acid moiety to improve solubility. It is supplied for research use and is designed for preparing linker-drug intermediates and conjugation to antibodies under controlled, reducing conditions.
- Cleavable disulfide linker enabling reductive release of payload.
- Sulfonic acid group improves aqueous solubility.
- High solubility in DMSO (≥125 mg/mL) for formulation flexibility.
- Compatible with standard ADC conjugation workflows.
- Requires cold storage and protection from light for stability.
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![eMolecules Medchem Express / Lurasidone / 10mg / 446271948 / HY-B0032A / / 367514-87-2 / [null] / 492.680 / C28H36N4O2S](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502450904.PNG-250.jpg)
eMolecules Medchem Express / Lurasidone / 10mg / 446271948 / HY-B0032A / / 367514-87-2 / [null] / 492.680 / C28H36N4O2S
Medchem Express / Lurasidone / 10mg / 446271948 / HY-B0032A / / 367514-87-2 / [null] / 492.680 / C28H36N4O2S
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Medchemexpress LLC HY-16900 100mg , Rolipram (R,S)-Rolipram;SB 95952;ZK 62711 CAS:61413-54-5 Purity:98%
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Medchemexpress, HY-16900 100mg Rolipram (R,S)-Rolipram;SB 95952;ZK 62711 CAS:61413-54-5 Formula:C16H21NO3 IC50: 3 nM (PDE4A), 130 nM (PDE4B), 240 nM (PDE4D) Purity:98% Rolipram is a selective inhibitor of phosphodiesterases PDE4 with IC 50 of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively. Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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eMolecules N,N,N?,N?Bis(tetramethylene)-O-(N-succinimidyl)uronium hexafluorophosphate | 207683-26-9 | MFCD00192457 | 25g
Chem-Impex | N,N,N?,N?Bis(tetramethylene)-O-(N-succinimidyl)uronium hexafluorophosphate | 25g | 386903705 | 31212 | | 207683-26-9 | MFCD00192457 | 411.285 | C13H20F6N3O3P
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![eMolecules Medchem Express / BMS-813160 / 5mg / 446259618 / HY-109593 / / 1286279-29-5 / [null] / 484.649 / C25H40N8O2](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502469161.JPG-250.jpg)
eMolecules Medchem Express / BMS-813160 / 5mg / 446259618 / HY-109593 / / 1286279-29-5 / [null] / 484.649 / C25H40N8O2
Medchem Express / BMS-813160 / 5mg / 446259618 / HY-109593 / / 1286279-29-5 / [null] / 484.649 / C25H40N8O2
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eMolecules 4-Bromophenyl trifluoroacetate | 5672-84-4 | MFCD01754394 | 1g
Oakwood Chemical | 4-Bromophenyl trifluoroacetate | 1g | 537706502 | 098448 | | 5672-84-4 | MFCD01754394 | 269.017 | C8H4BrF3O2
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