Quinolines and derivatives
Medchemexpress LLC ASP-9521 | 1126084-37-4 | 98.0% | 330.42 | 200 MG
ASP-9521 is a potent, selective, and orally available AKR1C3 inhibitor with an IC50 of 11 nM for human AKR1C3. It shows more than 100-fold selectivity for AKR1C3 over the isoform AKR1C2. This inhibitor suppresses AD-dependent PSA production and cell proliferation in LNCaP-AKR1C3 cells, and inhibits AD-induced intratumoural T production in CWR22R xenografts for up to 24 hours.
- Potent and selective AKR1C3 inhibitor
- Orally available
- High selectivity over AKR1C2
- Suppresses AD-dependent PSA production and cell proliferation
- Inhibits AD-induced intratumoural T production
- Inhibitory effect maintained for 24 hours
Medchemexpress LLC Potassium clavulanate cellulose | 61177-45-5 | 98.0% | 238.26 | 200 MG
Potassium clavulanate cellulose is a mixture of potassium clavulanate and cellulose. It acts as a bacterial β-lactamase inhibitor. Clavulanate potassium, a form of Clavulanic acid, combats bacteria resistant to penicillins and other antibiotics. When combined with amoxicillin, it can be used for research on various bacterial infections such as sinusitis, pneumonia, ear infections, bronchitis, urinary tract infections, and skin infections.
- Acts as a bacterial β-lactamase inhibitor
- Combats bacteria resistant to penicillins and other antibiotics
- Suitable for research on various bacterial infections
- Can be combined with amoxicillin for infection research
Apexbio Technology LLC Bitopertin(Synonyms: RG1678, RO4917838, RG-1678, RO-4917838), 200mg, CAS: 845614-11-1.
Bitopertin (CAS 845614-11-1) also known as RG1678 is a selective inhibitor of glycine transporter-1 (GlyT1) exhibiting an EC50 of 30 nM in vitro GlyT1 inhibition increases synaptic glycine a co-agonist at N-methyl-D-aspartate (NMDA) receptor glycine-binding sites thereby enhancing NMDA receptor-mediated glutamatergic neurotransmission This mechanism addresses glutamatergic dysfunction implicated in schizophrenia Clinical studies indicate that adjunctive bitopertin treatment improves negative symptoms in schizophrenia patients highlighting its therapeutic potential as a GlyT1-targeted research tool and drug candidate
Apexbio Technology LLC LKB1 (AAK1 dual inhibitor) 1093222-27-5 200mg
LKB1 (AAK1 dual inhibitor CAS 1093222-27-5) is a selective inhibitor targeting both LKB1 kinase and adaptor-associated kinase 1 (AAK1) These kinases are serine/threonine protein kinases implicated in cellular metabolism polarity and endocytic trafficking pathways respectively By simultaneously inhibiting LKB1 and AAK1 activity this small molecule modulates diverse intracellular signaling cascades associated with cell proliferation and membrane trafficking Due to these mechanistic features LKB1 (AAK1 dual inhibitor) serves as a valuable research tool for studying kinase-associated pathways in various biomedical contexts and potentially informing therapeutic strategies
Apexbio Technology LLC Sodium Phenylbutyrate 1716-12-7 200mg
Sodium Phenylbutyrate (CAS 1716-12-7) is a small-molecule inhibitor targeting histone deacetylase (HDAC) an enzyme involved in regulating histone acetylation an epigenetic mechanism implicated in cancer progression and cardiac dysfunction In oral squamous cell carcinoma cell lines (CAL27 HSC3 SCC4) Sodium Phenylbutyrate demonstrated dose-dependent cell growth inhibition (IC50 4 091 3 712 and 3 015 mM respectively) and decreased cell viability in a time-dependent manner In a mouse Adriamycin-induced cardiac injury model treatment with Sodium Phenylbutyrate significantly attenuated cardiac enzyme elevations improved cardiac function and increased cardiac MnSOD protein expression and activity Sodium Phenylbutyrate serves as an important research tool for cancer biology and cardiotoxicity studies
Medchemexpress LLC Nintedanib esylate | 656247-18-6 | 649.76 | 50 MG
Nintedanib esylate | 656247-18-6 | 649.76 | 50 MG
Medchemexpress LLC 5-Hydroxyquinoline | 578-67-6 | 99.5% | 145.16 | 1 G
5-Hydroxyquinoline is an organic compound commonly used in chemical reactions and biological research. It is utilized in the manufacture of dyes, cellulase, oxidants, and passivators, and finds wide application in the pigment, paint, and rubber industries. This compound also serves as a precursor, intermediate, and metal ion complexing agent for various drugs, and is a biochemical reagent for life science-related research.
- Used in chemical reactions and biological research.
- Manufacture of dyes, cellulase, oxidants, and passivators.
- Widely used in pigment, paint, and rubber industries.
- Precursor, intermediate, and metal ion complexing agent for certain drugs.
- Biochemical reagent for life science related research.
- Laboratory chemical.
- For research use only.
Medchemexpress LLC Pictilisib (dimethanesulfonate) | 957054-33-0 | 99.7% | 705.85 | 200 MG
Pictilisib dimethanesulfonate is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM, with modest selectivity against p110β (11-fold) and p110γ (25-fold).
- Potent inhibitor of PI3Kα/δ with IC50 of 3 nM
- Modest selectivity against p110β (11-fold) and p110γ (25-fold)
- Reduces tumor cell viability in breast cancer cell lines
- Inhibits Akt phosphorylation and downstream targets of Akt signaling
- Shows high efficacy of antitumor activity in ZD1839-resistant non-small cell lung cancer (NSCLC) cell lines (A549 and H460)
- Highly efficacious in combination with U0126 in inducing cell growth inhibition, G0-G1 arrest, and cell apoptosis
- Reduces secreted VEGF after hypoxic/anoxic exposure
- Leads to tumor stasis in animal models
- Results in tumor regressions during treatment leading to enhanced antitumor responses
- Reduces tumor growth and PI3K and HIF-1 pathway activity in tumor-bearing mice
Medchemexpress LLC Branaplam | 1562338-42-4 | 98.90% | 393.48 | 200 MG
Branaplam is a highly potent, selective and orally active survival motor neuron-2 (SMN2) splicing modulator with an EC50 of 20 nM for SMN. It inhibits human-ether-a-go-go-related gene (hERG) with an IC50 of 6.3 μM. Branaplam elevates full-length SMN protein and extends survival in a severe spinal muscular atrophy (SMA) mouse model.
- Highly potent, selective and orally active survival motor neuron-2 (SMN2) splicing modulator.
- Elevates full-length SMN protein.
- Extends survival in a severe spinal muscular atrophy (SMA) mouse model.
- EC50 of 20 nM for SMN.
- IC50 of 6.3 μM for hERG.
Medchemexpress LLC Amino-PEG6-amine | 76927-70-3 | MFCD30343546 | 97.0% | 324.41 | 250 MG
Amino-PEG6-amine is a PROTAC linker, based on a PEG (polyethylene glycol) chain with 6 units, which can be utilized in the synthesis of PROTACs. PROTACs are molecules that contain two different ligands connected by a linker: one ligand binds to an E3 ubiquitin ligase, and the other binds to the target protein. This mechanism allows PROTACs to leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based (6 units) PROTAC linker
- Can be used in the synthesis of PROTACs
Medchemexpress LLC m-PEG11-amine | 854601-60-8 | 515.64 g/mol | C23H49NO11 | 250 MG
m-PEG11-amine is a methoxy-terminated polyethylene glycol linker bearing a terminal primary amine. It provides an approximately 11-unit PEG spacer (hydrophilic) for conjugation to payloads or ligands, improving solubility and flexibility, and is used as a cleavable linker in antibody-drug conjugates (ADCs) and as a PEG-based linker in PROTAC synthesis.
- Cleavable PEG linker with a terminal primary amine.
- Approximately 11 ethylene glycol units; molecular weight 515.64 g/mol.
- Enhances solubility and linker flexibility for bioconjugation.
- Used in ADC and PROTAC syntheses and general bioconjugation applications.
- Available in small laboratory pack sizes (e.g., 250 MG) for research use.
Apexbio Technology LLC Nutlin-3a chiral 675576-98-4 200mg
Nutlin-3a chiral (CAS 675576-98-4) is a small-molecule antagonist targeting mouse double minute 2 (MDM2) which functions as a negative regulator of the tumor suppressor TP53 By binding directly to the TP53-interacting pocket of MDM2 Nutlin-3a blocks the degradation of TP53 stabilizing the protein and activating TP53-dependent pathways Studies in solid tumors and lymphomas indicate that Nutlin-3a induces cell cycle arrest growth inhibition and apoptosis Research has demonstrated antitumor activity in vitro and in vivo highlighting its utility in studying TP53-related cell signaling pathways and its potential in cancer research applications
Apexbio Technology LLC CUDC-907 1339928-25-4 200mg
CUDC-907 (CAS 1339928-25-4) is a dual inhibitor targeting histone deacetylases (HDACs 1 2 3 10) and class I phosphatidylinositol 3-kinases (PI3K) It exhibits nanomolar inhibitory activity against these enzymes blocking PI3K-mediated Akt signaling and increasing acetylation of histones and non-histone substrates (e g tubulin p53) In cancer cell models CUDC-907 induces G2-M phase arrest and reduces phosphorylation of downstream proteins such as p70S6 4EBP-1 MEK STAT3 and SRC Preclinical studies demonstrate its anti-tumor activity in lymphoma and NSCLC xenografts making it relevant for oncology research
Medchemexpress LLC Olmutinib | 1353550-13-6 | 99.5% / 99.9% | 486.59 | 200 MG
Olmutinib is an orally active and irreversible third-generation EGFR tyrosine kinase inhibitor. It binds to a cysteine residue near the kinase domain and is used for Non-Small Cell Lung Cancer (NSCLC). This product is for research use only.
- Orally active
- Irreversible third-generation EGFR tyrosine kinase inhibitor
- Binds to a cysteine residue near the kinase domain
- Used for Non-Small Cell Lung Cancer (NSCLC)
- For research use only
Medchemexpress LLC Quinidine (15% dihydroquinidine) | 56-54-2 | 98.4% | 50 G
Quinidine (15% dihydroquinidine) is an antiarrhythmic agent and a potent, orally active, selective cytochrome P450db inhibitor. It also acts as a K+ channel blocker with an IC50 of 19.9 μM and can induce apoptosis. This product is suitable for malaria research and has shown cytotoxicity against MES-SA cells, as well as effects on the PTZ-induced seizure threshold.
- Acts as an antiarrhythmic agent
- Potent, orally active, selective cytochrome P450db inhibitor
- Functions as a K+ channel blocker
- Capable of inducing apoptosis
- Applicable for malaria research
- Exhibits cytotoxicity against MES-SA cells
- Affects PTZ-induced seizure threshold