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Filtered Search Results
Apexbio Technology LLC Proflavine Hemisulfate 1811-28-5 10mM (in 1mL DMSO)
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Proflavine Hemisulfate (CAS 1811-28-5) is a small-molecule inhibitor targeting DNA It is designed to intercalate into DNA strands thereby disrupting DNA replication and transcription Proflavine Hemisulfate exerts its biological activity primarily through DNA intercalation In in vitro studies Proflavine Hemisulfate demonstrates antimicrobial activity with reported IC50 values for inhibiting bacterial growth typically ranging between 1 10 M depending on the microbial strain and assay conditions used Based on these pharmacological properties Proflavine Hemisulfate holds research potential in studies of antimicrobial activity DNA replication assays mutagenesis and evaluating sensitivity and resistance profiles of microorganisms
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Apexbio Technology LLC Rotundine 483-14-7 200mg
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Rotundine (CAS 483-14-7) also known as levo-tetrahydropalmatine (l-THP) is an isoquinoline alkaloid derived from plant species such as Stephania and Corydalis Pharmacologically l-THP acts as an antagonist at both D1 and D2 dopamine receptors exhibiting higher affinity for D1 (Ki 124 nM IC50 166 nM) than for D2 receptors (Ki 388 nM IC50 1 4 M) In vivo studies have shown that l-THP reduces spontaneous locomotor activity and operant responses in rodents in a dose-dependent manner Clinically approved in China l-THP is under investigation for its non-opioid analgesic properties and potential therapeutic utility in central nervous system-related disorders and substance use research
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000428591 PARTHENOLIDE 200MG
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000377103 KOBE0065 200MG
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000427868 CINCHONIDINE 500MG
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Apexbio Technology LLC Domperidone 57808-66-9 200mg
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Domperidone is a small-molecule antagonist targeting the dopamine D2 receptor It is designed to inhibit peripheral dopamine receptors thereby enhancing gastrointestinal motility and accelerating gastric emptying Domperidone exerts its biological activity primarily through peripheral D2 receptor antagonism Based on these pharmacological properties domperidone holds research potential in the investigation and management of gastroparesis and as a comparative compound for mechanistic studies of gastric motility disorders
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Apexbio Technology LLC 17-Hydroxyprogesterone 68-96-2 200mg
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17-Hydroxyprogesterone (68-96-2) is a small-molecule agonist targeting the progesterone receptor (PR) with partial agonist activity at glucocorticoid receptors (GR) and antagonist effects at mineralocorticoid receptors (MR) It modulates steroid hormone signaling pathways thereby influencing vascular tone and inflammation 17-Hydroxyprogesterone exerts its biological activity primarily through activation and modulation of steroid hormone receptors In animal models administration of 17-Hydroxyprogesterone demonstrates the ability to modulate vascular inflammation and uterine vascular tone Based on these pharmacological properties 17-Hydroxyprogesterone holds research potential in the screening of congenital adrenal hyperplasia and related metabolic syndromes as well as associations with respiratory distress syndrome and premature birth outcomes
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Apexbio Technology LLC R 59-022 93076-89-2 5mg
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R 59-022 (CAS 93076-89-2) is a small molecule inhibitor of diacylglycerol kinase (DGK) demonstrating an IC50 of 2 8 M for DGK activity By inhibiting the conversion of 1-oleoyl-2-acetylglycerol to phosphatidic acid R 59-022 modulates diacylglycerol signaling pathways The compound also exhibits antagonistic effects at serotonin (5-HT) receptors and can induce activation of protein kinase C (PKC) In cellular studies R 59-022 enhances thrombin-induced diacylglycerol accumulation in platelets and suppresses phosphatidic acid formation in neutrophils It serves as a valuable tool for investigating DGK-mediated processes and signal transduction mechanisms
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000429555 SULFO-CY5-MAL 25MG
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Aobchem AOBCHEM
5000864255 2-FLUORO-1- METHYLSULFANYL -3-
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Aobchem AOBCHEM
5000864269 2-FLUORO-1- METHYLSULFANYL -3-
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Medchemexpress LLC Sitravatinib | 1123837-84-2 | 99.6% | 629.68 | 200 MG
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Sitravatinib (MGCD516) is an orally bioavailable receptor tyrosine kinase (RTK) inhibitor that demonstrates potent single-agent antitumor efficacy. It enhances the activity of PD-1 blockade by promoting an antitumor immune microenvironment, making it suitable for various research applications in oncology.
- Orally bioavailable receptor tyrosine kinase (RTK) inhibitor
- Potent single-agent antitumor efficacy
- Enhances PD-1 blockade activity
- Promotes an antitumor immune microenvironment
- Soluble in DMSO for in vitro studies
- Available in solid form for various research needs
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Medchemexpress LLC Dacomitinib | 1110813-31-4 | 469.94 | 200 MG
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Dacomitinib (PF-00299804) is a specific and irreversible inhibitor of the ERBB family of kinases. It exhibits IC50s of 6 nM, 45.7 nM, and 73.7 nM for EGFR, ERBB2, and ERBB4, respectively.
- Targets EGFR and apoptosis
- Inhibits JAK/STAT signaling and protein tyrosine kinase/RTK pathways
- Available as a solid
- Molecular formula: C24H25ClFN5O2
- Recommended storage for powder: -20°C (3 years) or 4°C (2 years)
- Recommended storage in solvent: -80°C (2 years) or -20°C (1 year)
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Medchemexpress LLC Mirin | 1198097-97-0 | MFCD05885480 | 99.6% | 220.25 | 200 MG
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Mirin | 1198097-97-0 | MFCD05885480 | 99.6% | 220.25 | 200 MG
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Medchemexpress LLC Infigratinib | 872511-34-7 | 99.8% | 560.48 | 200 MG
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Infigratinib, also known as BGJ-398 or NVP-BGJ398, is a potent inhibitor of the Fibroblast Growth Factor Receptor (FGFR) family. It targets FGFR1, FGFR2, FGFR3, and FGFR4 with high efficacy, making it suitable for various research applications.
- Potent inhibitor of FGFR1, FGFR2, FGFR3, and FGFR4
- Inhibits proliferation of FGFR-dependent BaF3 cells
- Effective against FGFR2-mutant endometrial cancer cells
- Extensively studied in clinical trials for multiple cancers and conditions
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