Quinolines and derivatives
Medchemexpress LLC B7-H2/ICOSLG Mouse 1mg
B7-H2/ICOSLG is an important ligand of the T cell receptor ICOS and mediates immune responses It acts as a costimulatory signal promoting T and B cell proliferation cytokine secretion and plasma cell differentiation B7-H2/ICOSLG Protein Mouse (HEK293 His) is the recombinant mouse-derived B7-H2/ICOSLG protein expressed by HEK293 with C-His labeled tag
Apexbio Technology LLC LY2940680 1258861-20-9 200mg
LY2940680 (CAS 1258861-20-9) is a selective antagonist of the Smoothened (Smo) receptor a seven-transmembrane G protein-coupled receptor involved in regulating Hedgehog (Hh) signalling LY2940680 binds primarily to the extracellular loops of Smo distinguishing it from previously described inhibitors such as SANT-1 which bind to the transmembrane domain By blocking Smo function LY2940680 suppresses downstream Hh pathway activation resulting in reduced cell proliferation observed in cell lines with Smo mutations or resistance to vismodegib Investigations of LY2940680 in basal cell carcinoma and medulloblastoma highlight its potential utility as a single-agent therapeutic targeting cancer stem cell populations
Apexbio Technology LLC Rimantadine 13392-28-4 200mg
Rimantadine (13392-28-4) is a small-molecule inhibitor targeting the M2 ion channel protein of influenza A virus It is designed to specifically block the M2 channel thereby inhibiting the viral uncoating process and preventing subsequent viral entry into host cells Rimantadine exerts its biological activity primarily through inhibition of the M2 ion channel In in vitro studies rimantadine demonstrates antiviral activity with reported IC50 values typically ranging from approximately 0 1 to 1 M depending on virus strain and experimental context Based on these pharmacological properties rimantadine holds research potential in investigating influenza A viral replication resistance mutations infection pathways and in evaluating antiviral activity and establishing infection models in vitro
TARGETMOL CHEMICALS INC Amorolfine hydrochloride 200MG
Also available in 1 mL, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Amorolfine hydrochloride (Amorolfine HCl) is an antifungal reagent. It exerts the antifungal activity by selectively interrupting two steps in the pathway of ergosterol synthesis and eventually disrupting the function and structure of fungal cell membrane. Amorolfine hydrochloride , a morpholine antifungal drug, can inhibit D14 reductase and D7-D8 isomerase. These enzymes can deplete ergosterol and cause ignosterol to accumulate in the fungal cytoplasmic cell membranes. Purity 100%
Medchemexpress LLC Resmetirom | 920509-32-6 | 99.9% | 200MG
Resmetirom | 920509-32-6 | 99.9% | 200MG
Apexbio Technology LLC CAY10505 1218777-13-9 200mg
CAY10505 is a small-molecule inhibitor targeting phosphatidylinositol 3-kinase gamma (PI3K ) It is designed to selectively inhibit PI3K thereby modulating cellular processes governed by the PI3K/Akt/mTOR signaling pathway CAY10505 exerts its biological activity primarily through inhibition of PI3K In cultured neuron studies CAY10505 demonstrates inhibition of baicalein-induced Akt phosphorylation with an IC50 value of approximately 30 nM Based on these pharmacological properties CAY10505 holds research potential in neuroscience cardiovascular biology and cancer biology studies
Medchemexpress LLC Sulfo-LC-SPDP (sodium) | 169751-10-4 | MFCD00083162 | >90.0% | 527.57 | C18H22N3NaO8S3 | 25 MG
Sulfo-LC-SPDP (sodium) is a water-soluble, cleavable heterobifunctional crosslinker that introduces a reducible disulfide linkage between amine and sulfhydryl groups. It is used as an ADC linker and for protein conjugation in research.
- Water-soluble, cleavable heterobifunctional linker.
- Introduces a reducible disulfide bond for controlled payload release.
- Contains an NHS ester for reaction with primary amines.
- Contains a pyridyldithiol group for reaction with thiols.
- Provided as the sodium salt for improved aqueous solubility.
- Available in small-mass quantities suitable for research-scale conjugation.
Apexbio Technology LLC Nimorazole 200mg
Nimorazole (6506-37-2) is a nitroimidazole-based small-molecule radiosensitizer designed to enhance cellular radiosensitivity in hypoxic tumor environments Nimorazole exerts its biological activity primarily through metabolic reduction under hypoxic conditions forming reactive intermediates that interact with cellular DNA and augment the effects of radiation therapy In experimental studies nimorazole demonstrates radiosensitizing properties with IC50 values commonly reported in the low millimolar range in vitro although the exact value varies by cell line and context Based on these pharmacological properties nimorazole holds research potential in oncology applications particularly for investigating radiotherapeutic strategies targeting hypoxia-affected neoplastic tissues such as head and neck squamous cell carcinoma
Medchemexpress LLC Lificiguat | 170632-47-0 | 99.7% | 304.34 | 200 MG
Lificiguat (YC-1) is a soluble guanylyl cyclase (sGC) activator that binds to the β subunit of sGC. It stimulates sGC activity, especially in the presence of CO or NO, leading to several hundred-fold activation. This compound has also been shown to inhibit tumor growth and improve rodent learning behavior.
- Binds to the β subunit of soluble guanylyl cyclase (sGC)
- Activates sGC, synergistically with carbon monoxide or nitric oxide
- Inhibits tumor growth
- Improves rodent learning behavior
- Enhances long-term potentiation (LTP)
Apexbio Technology LLC Fludarabine(Synonyms: Fludarabine Phosphate, Fludara, Fludarabinum, 2-Fluoro-ara-AMP, 9H-Purin-6-amine), 200mg, CAS: 21679-14-1.
Fludarabine (CAS 21679-14-1) is a purine analog prodrug that inhibits DNA synthesis Upon cellular uptake it undergoes phosphorylation to its active triphosphate form (F-ara-ATP) disrupting DNA replication through inhibition of critical enzymes such as DNA primase DNA ligase I ribonucleotide reductase and DNA polymerases and In human myeloma RPMI8226 cell assays fludarabine suppressed cell growth reduced Akt phosphorylation and lowered anti-apoptotic proteins XIAP and Survivin In vivo studies demonstrated marked tumor growth inhibition in RPMI8226 xenograft models Fludarabine serves as a tool in oncology research particularly leukemia and multiple myeloma-related studies
Apexbio Technology LLC PF-431396 717906-29-1 200mg
PF-431396 is a pyrimidine-based small-molecule inhibitor targeting proline-rich tyrosine kinase 2 (Pyk2) and focal adhesion kinase (FAK) It is designed to selectively inhibit these kinases thereby modulating signaling pathways involved in cellular adhesion migration and proliferation PF-431396 exerts its biological activity primarily through disruption of Pyk2 and FAK tyrosine autophosphorylation or transphosphorylation Based on these pharmacological properties PF-431396 holds research potential in the investigation of cancer biology inflammation and immunological cell responses in experimental models
Apexbio Technology LLC Trospium chloride 10405-02-4 200mg
Trospium chloride (CAS 10405-02-4) is a quaternary ammonium compound that functions as a competitive antagonist at muscarinic acetylcholine receptors thereby inhibiting cholinergic stimulation of the bladder detrusor muscle This action reduces involuntary bladder contractions leading to decreased urinary urgency frequency and urge incontinence Trospium chloride displays pharmacological properties distinct from tertiary amine antimuscarinics including limited central nervous system penetration It is widely utilized in preclinical and clinical research focused on urinary disorders and muscarinic receptor pharmacology
Apexbio Technology LLC KY 02111 1118807-13-8 200mg
KY 02111 (CAS 1118807-13-8) is a selective inhibitor of the Wnt signaling pathway acting downstream of GSK3 and APC within the -catenin destruction complex By modulating canonical Wnt signaling KY 02111 has been shown to significantly reduce luciferase reporter activity in IMR90-1 human induced pluripotent stem cells (hiPSCs) transfected with a TCF-responsive plasmid in a dose-dependent manner When applied to differentiating cardiac cell colonies KY 02111 induces the expression of cardiac-specific markers in approximately 73 85% of IMR90-1 hiPSCs by day 30 This compound is valuable for investigating Wnt-mediated cellular processes and optimizing protocols for directed differentiation of pluripotent stem cells
Medchemexpress LLC Urea, N-(2-((4-(diethylamino)butyl)amino)-6-(3,5-dimethoxyphenyl)pyrido(2,3-d)pyrimidin-7-yl)-N'-(1 | 219580-11-7 | MFCD08705327 | 99.9% | 523.7 g/mol | C28H41N7O3 | 200 MG
PD173074 is a small-molecule research compound that potently inhibits fibroblast growth factor receptor 1 (FGFR1). It shows an FGFR1 IC50 of ~25 nM, inhibits VEGFR2 with an IC50 of 100-200 nM, and demonstrates approximately 1,000-fold selectivity over PDGFR and c-Src. It is supplied for laboratory research use as an analytical/research standard.
- Potent FGFR1 inhibitor (IC50 ≈ 25 nM).
- Also inhibits VEGFR2 (IC50 100-200 nM).
- Approximately 1,000-fold selectivity for FGFR1 over PDGFR and c-Src.
- High purity (≈99.9%).
- Molecular weight 523.7 g/mol.
- CAS number 219580-11-7.
- For research use only.
Medchemexpress LLC Molibresib | 1260907-17-2 | 200 MG
Molibresib (I-BET762; GSK525762) is a BET bromodomain inhibitor with an IC₅₀ of 32.5-42.5 nM. It binds to the tandem bromodomains of BET with high affinity and displaces a tetra-acetylated H4 peptide. It has high affinity for the BD1/BD2 domain of BRD2/3/4 proteins and inhibits OPM-2 cell proliferation.
- BET bromodomain inhibitor
- High affinity for BD1/BD2 domain of BRD2/3/4 proteins
- Inhibits OPM-2 cell proliferation