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Quinolines and derivatives

Aromatic organic heterocyclic compounds that contain a benzene ring fused with a six-membered ring that contains one nitrogen atom and five carbon atoms. Includes compounds that are derived from quinolines.

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1

Apexbio Technology LLC GSK1070916 942918-07-2 200mg
SDP

GSK1070916 (CAS 942918-07-2) is a selective ATP-competitive inhibitor targeting Aurora kinase B and C displaying Ki values of 0 38 nM and 1 5 nM respectively The compound demonstrates marked selectivity over Aurora kinase A with IC50 values of approximately 5 nM (Aurora B) versus 1259 nM (Aurora A) In vitro studies show that GSK1070916 inhibits proliferation of human lung cancer cells (A549) with an EC50 of roughly 7 nM Additionally the compound effectively reduces phosphorylation of histone H3 an Aurora B substrate and exhibits tumor growth inhibition in HL-60 xenograft mouse models GSK1070916 is utilized in tumor biology research investigating Aurora kinase signaling pathways

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2

Medchemexpress LLC SARS-CoV-2-IN-86 | 368866-07-3 | MFCD02683117 | 99.4% | 466.53 | C26H30N2O6 | 1 G
SDP

SARS-CoV-2-IN-86 is a small-molecule research compound that inhibits SARS-CoV-2 methyltransferases (nsp14 and nsp16) and is reported as an andrographolide derivative. It is supplied as a solid or as a 10 mM solution in DMSO for in vitro antiviral and enzymatic studies. Batch-specific certificates of analysis and safety documentation are available from the supplier.

  • Inhibits SARS-CoV-2 methyltransferases (nsp14 and nsp16).
  • Andrographolide derivative for antiviral research.
  • Available as solid and 10 mM solution in DMSO.
  • High purity (≈99.4%) per supplier documentation.
  • Suitable for in vitro enzymatic and antiviral assays.
  • Powder stable at -20°C; solvent storage guidelines available.

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3

eMolecules​ 2-(5-Cyclopropyl-1,2,4-oxadiazol-3-yl)-3-methylpyridine | 1421262-07-8 | MFCD22682970 | 1g

Oakwood Chemicals | 2-(5-Cyclopropyl-1,2,4-oxadiazol-3-yl)-3-methylpyridine | 1g | 480147815 | 098101 | | 1421262-07-8 | MFCD22682970 | 201.229 | C11H11N3O

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4

Chemscene ChemScene | 2-Oxo-1,2-dihydroquinoline-6-sulfonyl chloride | 250MG | CS-0080680 | 0.97 | 569340-07-4| MFCD18300284 | 243.67
SDP

ChemScene | 2-Oxo-1,2-dihydroquinoline-6-sulfonyl chloride | 250MG | CS-0080680 | 0.97 | 569340-07-4| MFCD18300284 | 243.67

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5

Medchemexpress LLC 1-(9H-fluoren-9-ylmethoxycarbonyl)-4-[(2-methylpropan-2-yl)oxycarbonylamino]piperidine-4-carboxylic acid | 368866-07-3 | MFCD02683117 | 99.4% | 466.53 | C26H30N2O6 | 1 ML
SDP

SARS-CoV-2-IN-86 is a research-grade small molecule inhibitor of SARS-CoV-2 methyltransferases (nsp14 and nsp16), provided for in vitro biochemical and antiviral studies. It is available as solid material and as a 10 mM solution in DMSO, with documented purity and storage recommendations to support reproducible experimental use.

  • High purity (99.35%) for reproducible results.
  • Available as 10 mM solution in DMSO or as solid for flexible assay workflows.
  • Well-characterized chemical identity (CAS 368866-07-3) and formula for traceability.
  • Suitable for biochemical methyltransferase and antiviral research applications.
  • Defined storage conditions to preserve stability in powder and solution formats.
  • Datasheet available with specification and handling information.

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6

Apexbio Technology LLC Hexestrol 84-16-2 200mg
SDP

Hexestrol (CAS 84-16-2) is a small-molecule agonist targeting estrogen receptors ER and ER It is designed to selectively activate these receptors thereby regulating hormone-responsive gene expression and associated biological pathways Hexestrol exerts its biological activity primarily through direct agonist-mediated activation of ER and ER In in vitro studies Hexestrol demonstrates potent activation with reported EC50 values of approximately 0 07 nM for ER and 0 175 nM for ER Based on these pharmacological properties Hexestrol holds research potential in studies involving estrogen receptor signaling hormone-dependent cellular responses and pathologies related to estrogen deficiency

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