Quinolines and derivatives
Medchemexpress LLC Gilteritinib | 1254053-43-4 | 200MG
Gilteritinib (ASP2215) is a potent and ATP-competitive FLT3/AXL inhibitor with IC50s of 0 29 nM/0 73 nM respectively
Apexbio Technology LLC AM095 1345614-59-6 200mg
AM095 (CAS 1345614-59-6) is an orally bioavailable antagonist targeting the lysophosphatidic acid receptor 1 (LPA1) It selectively inhibits recombinant human and mouse LPA1 receptors with IC50 values of 0 98 M and 0 73 M respectively In cell-based assays AM095 suppresses LPA1-mediated chemotaxis in mouse LPA1/CHO and human melanoma A2058 cells (IC50 values 0 78 M and 0 23 M respectively) In vivo studies demonstrate its ability to prevent LPA-triggered histamine release reduce collagen and protein accumulation and limit inflammatory cell infiltration in mouse pulmonary models AM095 serves as a valuable tool for investigating LPA1-associated pathologies
Apexbio Technology LLC AM-095 free base 1228690-36-5 200mg
AM-095 free base (CAS 1228690-36-5) is an orally bioavailable antagonist of lysophosphatidic acid receptor 1 (LPA1) It demonstrates inhibitory activity against recombinant human and mouse LPA1 with IC50 values of 0 98 M and 0 73 M respectively In vitro AM-095 suppresses LPA1-mediated chemotaxis in both mouse LPA1/CHO cells (IC50 0 78 M) and human A2058 melanoma cells (IC50 0 23 M) In murine models it blocks LPA-induced histamine release and reduces collagen and protein levels in bronchoalveolar lavage fluid with ED50 values of 8 3 mg/kg and 10 mg/kg respectively Additionally AM-095 decreases macrophage and lymphocyte infiltration in bleomycin-induced lung injury models supporting its utility in studies of LPA1-mediated fibrotic and inflammatory processes
Apexbio Technology LLC Anastrozole 120511-73-1 200mg
Anastrozole (CAS 120511-73-1) is a selective non-steroidal aromatase inhibitor that suppresses estrogen biosynthesis by inhibiting the aromatase enzyme In in vitro assays using human placental aromatase anastrozole demonstrated an IC50 of 14 6 nM (0 0043 g/ml) Oral administration at 0 1 mg/kg completely inhibited ovulation in preclinical models and eliminated exogenous androgen-induced uterotrophic activity in juvenile rodents Additionally it has been shown to inhibit the conversion of 11-deoxycortisol to cortisol in guinea pig dog and bovine adrenal microsomes with IC50 values of 4 09 M 129 M and 11 9 M respectively Anastrozole is widely used in research to study estrogen-mediated pathways and endocrine modulation