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Quinolines and derivatives

Aromatic organic heterocyclic compounds that contain a benzene ring fused with a six-membered ring that contains one nitrogen atom and five carbon atoms. Includes compounds that are derived from quinolines.
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1

8-Hydroxyquinoline, ACS

CAS: 148-24-3 Molecular Formula: C9H7NO Molecular Weight (g/mol): 145.16 MDL Number: MFCD00006807 InChI Key: MCJGNVYPOGVAJF-UHFFFAOYSA-N Synonym: 8-hydroxyquinoline,8-quinolinol,oxyquinoline,oxine,quinophenol,8-quinol,8-oxyquinoline,phenopyridine,oxychinolin,bioquin PubChem CID: 1923 ChEBI: CHEBI:48981 IUPAC Name: quinolin-8-ol SMILES: OC1=C2N=CC=CC2=CC=C1

PubChem CID 1923
CAS 148-24-3
Molecular Weight (g/mol) 145.16
ChEBI CHEBI:48981
MDL Number MFCD00006807
SMILES OC1=C2N=CC=CC2=CC=C1
Synonym 8-hydroxyquinoline,8-quinolinol,oxyquinoline,oxine,quinophenol,8-quinol,8-oxyquinoline,phenopyridine,oxychinolin,bioquin
IUPAC Name quinolin-8-ol
InChI Key MCJGNVYPOGVAJF-UHFFFAOYSA-N
Molecular Formula C9H7NO
2

3,4-Dihydro-7-hydroxy-2(1H)-quinolinone 98.0+%, TCI America™

CAS: 22246-18-0 Molecular Formula: C9H9NO2 Molecular Weight (g/mol): 163.176 MDL Number: MFCD06410891 InChI Key: LKLSFDWYIBUGNT-UHFFFAOYSA-N Synonym: 3,4-dihydro-7-hydroxy-2 1h-quinolinone,7-hydroxy-3,4-dihydroquinolin-2 1h-one,7-hydroxy-3,4-dihydro-2 1h-quinolinone,3,4-dihydro-7-hydroxycarbostyril,7-hydroxy-3,4-dihydro-quinolin-2-one,7-hydroxy-3,4-dihydrocarbostyril,7-hydroxy-3,4-dihydro carbostyril,7-hydroxy-1,2,3,4-tetrahydroquinolin-2-one,2 1h-quinolinone, 3,4-dihydro-7-hydroxy,7-hydroxy-2-oxo-1,2,3,4-tetrahydroquinoline PubChem CID: 2785758 IUPAC Name: 7-hydroxy-3,4-dihydro-1H-quinolin-2-one SMILES: C1CC(=O)NC2=C1C=CC(=C2)O

PubChem CID 2785758
CAS 22246-18-0
Molecular Weight (g/mol) 163.176
MDL Number MFCD06410891
SMILES C1CC(=O)NC2=C1C=CC(=C2)O
Synonym 3,4-dihydro-7-hydroxy-2 1h-quinolinone,7-hydroxy-3,4-dihydroquinolin-2 1h-one,7-hydroxy-3,4-dihydro-2 1h-quinolinone,3,4-dihydro-7-hydroxycarbostyril,7-hydroxy-3,4-dihydro-quinolin-2-one,7-hydroxy-3,4-dihydrocarbostyril,7-hydroxy-3,4-dihydro carbostyril,7-hydroxy-1,2,3,4-tetrahydroquinolin-2-one,2 1h-quinolinone, 3,4-dihydro-7-hydroxy,7-hydroxy-2-oxo-1,2,3,4-tetrahydroquinoline
IUPAC Name 7-hydroxy-3,4-dihydro-1H-quinolin-2-one
InChI Key LKLSFDWYIBUGNT-UHFFFAOYSA-N
Molecular Formula C9H9NO2
3

7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid 98.0+%, TCI America™

CAS: 100361-18-0 Molecular Formula: C12H8ClFN2O3 Molecular Weight (g/mol): 282.655 MDL Number: MFCD08458865 InChI Key: OXNZWNNMJBOZQO-UHFFFAOYSA-N PubChem CID: 11055142 IUPAC Name: 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid SMILES: C1CC1N2C=C(C(=O)C3=CC(=C(N=C32)Cl)F)C(=O)O

PubChem CID 11055142
CAS 100361-18-0
Molecular Weight (g/mol) 282.655
MDL Number MFCD08458865
SMILES C1CC1N2C=C(C(=O)C3=CC(=C(N=C32)Cl)F)C(=O)O
IUPAC Name 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid
InChI Key OXNZWNNMJBOZQO-UHFFFAOYSA-N
Molecular Formula C12H8ClFN2O3
4

Apexbio Technology LLC Cyclophosphamide 50-18-0 200mg
SDP

Cyclophosphamide is a nitrogen mustard alkylating prodrug activated via hepatic enzymes to its active metabolites These metabolites alkylate DNA primarily at guanine residues resulting in DNA cross-linking strand breaks and mutations consequently triggering cytotoxic effects Cyclophosphamide exhibits cytotoxicity in vitro with an IC50 of 37 6 M in mouse embryo BALB/c 3T3 cells and an IC50 of 8 79 M against human HL60 cells It impacts immune regulation by decreasing regulatory T cell counts and suppressive marker expression (FoxP3 GITR) facilitating immune response modulation Commonly applied in cancer and immunological research cyclophosphamide is also employed in genotoxicity assays due to its capacity to induce chromosomal aberrations and mutations

ENCOMPASS_PREFERRED
5

Medchemexpress LLC Tivozanib | 475108-18-0 | 99.8% | 454.86 | 100 MG
SDP

Tivozanib is a selective, orally active inhibitor for vascular endothelial growth factor receptor (VEGFR)-1, 2, and 3. It demonstrates antitumor efficacy and is suitable for research use.

  • Selectively inhibits VEGFR-1, 2, and 3 with low nanomolar IC50 values
  • Inhibits VEGF-induced proliferation and migration of HUVECs
  • Exhibits antitumor efficacy across various cancer models in athymic mice
  • Reversibly suppresses vascular permeability and angiogenesis

ENCOMPASS_PREFERRED
6

Medchemexpress LLC Guanidinoethyl sulfonate | 543-18-0 | 99.9% | 167.19 | 50 MG
SDP

Guanidinoethyl sulfonate | 543-18-0 | 99.9% | 167.19 | 50 MG

ENCOMPASS_PREFERRED
7

Medchemexpress LLC Canagliflozin | 842133-18-0 | MFCD18251436 | 99.7% | 444.52 | C24H25FO5S | 200 MG
SDP

Canagliflozin is a selective sodium-glucose cotransporter 2 (SGLT2) inhibitor provided as a research-grade powder for biochemical and pharmacological studies. It exhibits low-nanomolar potency against SGLT2 and is used in in vitro and in vivo experiments to investigate glucose transport and metabolic pathways.

  • Selective SGLT2 inhibitor with low-nanomolar IC50 values.
  • High purity suitable for analytical and research use (≈99.7% LCMS).
  • Solid powder form for flexible formulation and dosing.
  • Stable under recommended storage conditions (powder: -20°C and 4°C).
  • Molecular weight 444.52 and formula C24H25FO5S.

ENCOMPASS_PREFERRED
8

Medchemexpress LLC Guanidinoethyl sulfonate (Standard) | 543-18-0 | 99.9% | 167.19 | 10 MG
SDP

Guanidinoethyl sulfonate (Standard) | 543-18-0 | 99.9% | 167.19 | 10 MG

ENCOMPASS_PREFERRED
9

Medchemexpress LLC Guanidinoethyl sulfonate | 543-18-0 | MFCD00084865 | 99.9% | 167.19 g/mol | C3H9N3O3S | 5 MG
SDP

Guanidinoethyl sulfonate (taurocyamine) is a small-molecule research reagent that inhibits taurine transport and antagonizes glycine receptors in the central nervous system. It is blood-brain barrier permeable and has been used in neuroprotection studies of ischemic brain injury; it also exhibits weak modulatory effects on GABAA receptors.

ENCOMPASS_PREFERRED
10

Medchemexpress LLC Ethanesulfonic acid, 2-[(aminoiminomethyl)amino]- | 543-18-0 | 99.9% | 167.19 | 100 MG
SDP

Guanidinoethyl sulfonate (Standard) is an analytical standard and an orally available, blood-brain permeable competitive inhibitor of taurine transporters. It acts as a competitive antagonist of glycine receptors (GlyR) (IC50=565 μM) and shows weak agonist/antagonist effects on GABAA receptors. It inhibits taurine transmembrane transport, blocks glycine-mediated chloride influx, and may regulate brain pH for neuroprotective effects, useful in studies of ischemic brain injury. It is applied in qualitative, quantitative, and methodological research experiments including HPLC, GC, and MS.

  • Analytical standard for research
  • Orally available and blood-brain permeable
  • Inhibits taurine transporters
  • Antagonizes glycine receptors
  • Modulates GABAA receptors
  • Blocks glycine-mediated chloride influx
  • May offer neuroprotective effects
  • Used in HPLC, GC, and MS applications

ENCOMPASS_PREFERRED
11

Chem-Impex International, Inc. 7-Hydroxy-3,4-Dihydro-2(1H)-quinolinone | 22246-18-0 | MFCD06410891 | 5G

7-Hydroxy-3,4-Dihydro-2(1H)-quinolinone, 22246-18-0, MFCD06410891, 5G

ENCOMPASS_PREFERRED
12

Chem-Impex International, Inc. 7-Hydroxy-3,4-Dihydro-2(1H)-quinolinone | 22246-18-0 | MFCD06410891 | 25G

7-Hydroxy-3,4-Dihydro-2(1H)-quinolinone, 22246-18-0, MFCD06410891, 25G

ENCOMPASS_PREFERRED
13

Accela Chembio Inc 7-hydroxy-3 | 4-dihydro-2(1h)-quinolinone | 25g | 22246-18-0 | MFCD06410891 | 97+% | Shelf Life: 1260 Days | Light Sensitive
SDP

7-hydroxy-3 | 4-dihydro-2(1h)-quinolinone | 25g | 22246-18-0 | MFCD06410891 | 97+% | Shelf Life: 1260 Days | Light Sensitive

ENCOMPASS_PREFERRED
14

Accela Chembio Inc 7-hydroxy-3 | 4-dihydro-2(1h)-quinolinone | 100g | 22246-18-0 | MFCD06410891 | 97+% | Shelf Life: 1260 Days | Light Sensitive
SDP

7-hydroxy-3 | 4-dihydro-2(1h)-quinolinone | 100g | 22246-18-0 | MFCD06410891 | 97+% | Shelf Life: 1260 Days | Light Sensitive

ENCOMPASS_PREFERRED
15

eMolecules​ 1-Cyclopropyl-6-fluoro-7-chloro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid | 100361-18-0 | 1G | Purity: 95%

Matrix Scientific | 1-Cyclopropyl-6-fluoro-7-chloro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid | 1G | 100361-18-0 | MFCD08458865

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