Quinolines and derivatives
Apexbio Technology LLC Tandutinib (MLN518) 387867-13-2 200mg
Tandutinib (MLN518 CAS 387867-13-2) is a selective small molecule inhibitor primarily targeting FLT3 with additional activity against PDGFR and c-Kit In biochemical kinase assays Tandutinib exhibits IC50 values of 0 22 M for FLT3 0 20 M for PDGFR and 0 17 M for c-Kit It effectively inhibits tyrosine phosphorylation of both wild-type FLT3 and FLT3 mutants with IC50 values in the 30 100 nM range In cellular models Tandutinib demonstrates anti-proliferative effects in FLT3-ITD-positive cell lines (Molm-13 Molm-14) at low nanomolar concentrations whereas FLT3-ITD-negative cells are substantially less sensitive This compound is utilized in research investigating FLT3-mediated signaling and acute myelogenous leukemia (AML) pathogenesis
Medchemexpress LLC 3,6,9,12,15,18,21,24-octaoxapentacosan-1-amine | 869718-81-0 | MFCD13184961 | ≥98.0% | 383.48 g/mol | C17H37NO8 | 5 G
m-PEG8-Amine is a polyethylene glycol (PEG) based cleavable linker terminating in a primary amine, used for bioconjugation and the synthesis of antibody-drug conjugates. It provides an eight-unit PEG spacer to improve solubility and flexibility when coupling payloads to biomolecules.
- Primary amine-terminated PEG spacer (8 units)
- Cleavable linker suitable for bioconjugation and ADC synthesis
- High purity: ≥98.0% (NMR)
- Molecular weight: 383.48 g/mol
- Chemical formula: C17H37NO8
- CAS number: 869718-81-0
- Storage: store at 4°C and protect from light; in solvent store at -80°C (6 months) or -20°C (1 month)
Medchemexpress LLC Acridine orange 10-nonyl bromide | 75168-11-5 | 99.5% | 472.50 | 25 MG
Acridine Orange 10-Nonyl Bromide is a fluorescent probe for cardiolipin with an excitation wavelength (λex) of 489 nm and an emission wavelength (λem) of 525 nm. It is used for research purposes only.
- Fluorescent probe for cardiolipin.
- Can be used to quantify cardiolipin in isolated mitochondria.
- At 4.75 μM, it saturates mitochondrial binding sites in 1.5 X 10^6 cells within 15 minutes at 20°C.
- Upon interaction with cardiolipin, the dye's excitation and emission wavelengths shift from 496 nm and 525 nm to 450 nm and 640 nm, respectively.
- Increasing amounts of cardiolipin (0 to 30 μM) and other acidic phospholipids in thin-walled vesicles, when added to 45 μM Acridine Orange 10-Nonyl Bromide, changes the red fluorescence emission measured at 640 nm according to the liposome composition.
Apexbio Technology LLC Kobe0065 436133-68-5 200mg
Kobe0065 (CAS 436133-68-5) is a small-molecule inhibitor targeting Ras proteins by disrupting the interaction between GTP-bound H-Ras or M-Ras and the Ras-binding domain of c-Raf-1 Identified via in silico screening Kobe0065 inhibits H-Ras GTP c-Raf-1 binding with a Ki of 46 M In NIH 3T3 cells it decreases the association of mutant H-RasG12V with c-Raf-1 in a dose-dependent manner (IC50 10 M) and suppresses downstream phosphorylation of MEK and ERK at 20 M In colony formation assays Kobe0065 inhibits proliferation of H-rasG12V transfected NIH 3T3 cells (IC50 0 5 M) and demonstrates activity against Ras-mutant cancer cell lines In xenograft models administration reduces tumor growth Kobe0065 serves as a research tool for studying Ras-mediated signaling and potential anti-tumor mechanisms