Tetrapyrroles and derivatives
Abcam Pimobendan (Vetmedin), Ca2+ channel sensitizer, 5MG
MW 334.4 Da, Purity >99%. Ca2+ channel sensitizer. Selective PDE3 inhibitor. Inhibits platelet aggregation. Shows antithrombotic, antihypertensive, potent inotropic and vasodilatory effects *in vivo.* Orally active.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Pimobendan (Vetmedin), Ca2+ channel sensitizer, 10MG
MW 334.4 Da, Purity >99%. Ca2+ channel sensitizer. Selective PDE3 inhibitor. Inhibits platelet aggregation. Shows antithrombotic, antihypertensive, potent inotropic and vasodilatory effects *in vivo.* Orally active.
The product is subject to the following: Abcam Restricted Use Statement
Abcam SEN 12333, alpha7 nicotinic acetylcholine receptor (nAChR) agonist, 10MG
MW 339.4 Da, Purity >98%. Potent, selective α7 nicotinic acetylcholine receptor (nAChR) agonist. High affinity for rat α7 receptors (Ki = 260 nM). Full agonist in functional Ca²+ flux studies (EC₅₀ = 1.6 μM). Active in vivo and in vitro. Excellent brain penetration. Orally bioavailable.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Monosodium urate, Pro-inflammatory agent, 2MG
MW 190.09 Da. NLRP3/NALP3 inflammasome activator. Stimulates caspase-1 activating NLRP3/NALP3 inflammasome, results in active IL-1β and IL-18 production. Active in vitro and in vivo.
The product is subject to the following: Abcam Restricted Use Statement
Sigma Aldrich Fine Chemicals Biosciences Hemin | 16009-13-5 | MFCD00010726 | 1g
Hemin | Purity: 90% | Mol Wt: 651.94 | 16009-13-5 | MFCD00010726 | 1g
Abcam Paprotrain, MKLP-2 inhibitor, 1MG
MW 245.28 Da, Purity >98%. Selective cell-permeable MKLP-2 inhibitor. Reversible ATP-noncompetitive ATPase inhibitor (IC₅₀ values are 1.35 and 0.83 μM for basal and microtubule-stimulated activity respectively). Inhibits Aurora B. Induces cell cycle arrest at early metaphase I.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Undecylprodigiosin, Apoptotic and anticancer agent, 1MG
MW 393.6 Da, Purity >93%. Apoptotic and anticancer agent. Selectively induces p53-independant apoptosis in cancer cells. Induces G2/M cell cycle arrest and shows antiproliferative effects. Shows antimalarial and antibactieral effects in vivo.
The product is subject to the following: Abcam Restricted Use Statement
Abcam L-745870 trihydrochloride, brain penetrant D4 antagonist, 50MG
MW 436.21 g/mol, Purity >99%. Highly potent and selective D₄ antagonist (Ki values are 0.43, 2300 and 960 nM at D₄, D₃ and D₂, respectively). Brain permeable. Inhibits cell death and shows neuroprotective effects.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Undecylprodigiosin, Apoptotic and anticancer agent, 250UG
MW 393.6 Da, Purity >93%. Apoptotic and anticancer agent. Selectively induces p53-independant apoptosis in cancer cells. Induces G2/M cell cycle arrest and shows antiproliferative effects. Shows antimalarial and antibactieral effects in vivo.
The product is subject to the following: Abcam Restricted Use Statement
Abcam EMD 386088 hydrochloride, 5-HT6 agonist, 10MG
MW 283.2 Da, Purity >98%. Potent 5-HT6 agonist (IC50 = 7.4 nM in 3H-LSD binding and EC50 = 1.0 nM in a functional cAMP assay). Selective over other 5-HT receptors (IC50 values are 110 (5-HT1D), 180 (5-HT1B), 240 (5-HT2A), 450 (5-HT2C), 620 (5-HT4), 660 (5-HT1A ) and 3000 nM (5-HT7)). Shows moderate affinity at 5-HT3 receptors (IC50 = 34 nM). Impairs memory *in vivo*.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Rotigotine hydrochloride, Dopamine receptor agonist, 50MG
MW 351.93 g/mol, Purity >99%. Dopamine receptor agonist. High affinity for D₁, D₂ and D₃ receptors (Ki values are 83, 13 and 0.71 nM, respectively). Shows significant affinity at α₂B and 5-HT₁A receptors (Ki values are 27 and 30 nM, respectively). Exhibits anti-Parkinsonian and antidepressant activity.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Rotigotine hydrochloride, Dopamine receptor agonist, 10MG
MW 351.93 g/mol, Purity >99%. Dopamine receptor agonist. High affinity for D₁, D₂ and D₃ receptors (Ki values are 83, 13 and 0.71 nM, respectively). Shows significant affinity at α₂B and 5-HT₁A receptors (Ki values are 27 and 30 nM, respectively). Exhibits anti-Parkinsonian and antidepressant activity.
The product is subject to the following: Abcam Restricted Use Statement
Abcam GS 39783, GABAB positive allosteric modulator, 50MG
MW 337.4 Da, Purity >99%. Novel, GABAB positive allosteric modulator (EC50 = 3 μM for [35S]GTPγS binding). Shows anxiolytic and antiaddictive effects *in vivo.* Blood-brain barrier permeable*.* Orally active.
The product is subject to the following: Abcam Restricted Use Statement
Abcam GS 39783, GABAB positive allosteric modulator, 10MG
MW 337.4 Da, Purity >99%. Novel, GABAB positive allosteric modulator (EC50 = 3 μM for [35S]GTPγS binding). Shows anxiolytic and antiaddictive effects *in vivo.* Blood-brain barrier permeable*.* Orally active.
The product is subject to the following: Abcam Restricted Use Statement
Creative Biomart Hemin
The product is an iron-containing porphyrin. More specifically, it is protoporphyrin IX containing a ferric iron ion (heme B) with a chloride ligand.