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Human GIP(3-30), amide TFA is the TFA salt form of human GIP(3-30), amide (HY-P10138). It acts as a high-affinity antagonist of the human GIP receptor in vitro. This compound shows potential for anti-obesity and anti-diabetic effects.
High affinity antagonist of the human GIP receptor in vitro.
AMI-1 (CAS 20324-87-2) is a small molecule inhibitor of protein arginine N-methyltransferase 1 (PRMT1) exhibiting an IC50 of 8 8 M It acts by preventing the binding of peptide substrates to PRMT1 without interfering with the S-adenosyl-L-methionine (SAM) cofactor binding site In addition to its action on PRMT1 AMI-1 inhibits HIV-1 reverse transcriptase polymerase activity with an IC50 of 5 0 M AMI-1 is cell-permeable facilitating its use in cellular studies investigating arginine methylation epigenetic regulation and viral replication
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
Human GIP(3-30), amide is a high-affinity antagonist of the human GIP receptor in vitro. It is being investigated for its potential anti-obesity and anti-diabetic effects.
High affinity antagonist: Competitively binds to the GIP receptor (GIPR), blocking GIP-mediated cAMP accumulation (Ki=16.8 nM), β-arrestin recruitment (Ki for β-arrestin-1/2 recruitment is 10.6 nM and 10.2 nM), and receptor internalization.
Inhibits insulin secretion: It has been shown to inhibit GIP-mediated insulin secretion and signal transduction in adipocytes.
Selective for human GIP receptor: This compound demonstrates high-affinity binding to primate GIP receptors but not rodent GIP receptors.
Research use only: This product is intended solely for research purposes and is not for sale to patients.
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More