Thienothiazines
![(S)-6-Chloro-4-hydroxy-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine 1,1-Dioxide 98.0+%, TCI America™](https://assets.fishersci.com/TFS-Assets/CCG/Chemical-Structures/chemical-structure-cas-160982-16-1.jpg-250.jpg)
(S)-6-Chloro-4-hydroxy-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine 1,1-Dioxide 98.0+%, TCI America™
CAS: 160982-16-1 Molecular Formula: C6H6ClNO3S2 Molecular Weight (g/mol): 239.688 MDL Number: MFCD09033311 InChI Key: OFJGKGNJDCLNPM-SCSAIBSYSA-N PubChem CID: 11746721 IUPAC Name: (4S)-6-chloro-1,1-dioxo-3,4-dihydro-2H-thieno[3,2-e]thiazin-4-ol SMILES: C1C(C2=C(SC(=C2)Cl)S(=O)(=O)N1)O
Brinzolamide 98.0+%, TCI America™
CAS: 138890-62-7 Molecular Formula: C12H21N3O5S3 Molecular Weight (g/mol): 383.496 MDL Number: MFCD08067749 InChI Key: HCRKCZRJWPKOAR-JTQLQIEISA-N Synonym: (R)-4-(Ethylamino)-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-Dioxide PubChem CID: 68844 ChEBI: CHEBI:41212 IUPAC Name: (4R)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-3,4-dihydrothieno[3,2-e]thiazine-6-sulfonamide SMILES: CCNC1CN(S(=O)(=O)C2=C1C=C(S2)S(=O)(=O)N)CCCOC
Lornoxicam 98.0+%, TCI America™
CAS: 70374-39-9 Molecular Formula: C13H10ClN3O4S2 Molecular Weight (g/mol): 371.81 MDL Number: MFCD00866163 InChI Key: WLHQHAUOOXYABV-UHFFFAOYSA-N Synonym: 6-Chloro-4-hydroxy-2-methyl-N-(2-pyridyl)-2H-thieno[2,3-e][1,2]thiazine-3-carboxamide 1,1-Dioxide PubChem CID: 54690031 ChEBI: CHEBI:31783 IUPAC Name: 6-chloro-4-hydroxy-2-methyl-1,1-dioxo-N-pyridin-2-ylthieno[2,3-e]thiazine-3-carboxamide SMILES: CN1C(=C(C2=C(S1(=O)=O)C=C(S2)Cl)O)C(=O)NC3=CC=CC=N3
Brinzolamide 138890-62-7 50mg
Brinzolamide (CAS 138890-62-7) is a potent and selective inhibitor of carbonic anhydrase II (CA II) with an IC50 of 3 19 nM and a Ki of 0 13 nM in vitro By inhibiting CA II brinzolamide disrupts the reversible hydration of carbon dioxide thereby reducing aqueous humor production and lowering intraocular pressure Demonstrated to have higher affinity and inhibitory efficacy for CA II compared to CA I and CA IV brinzolamide has been shown to significantly decrease intraocular pressure in animal models Additionally it is utilized in research settings to assess cerebral blood flow reserve as CA inhibition modulates tissue CO2 levels and consequent vasodilation
Lornoxicam 70374-39-9 10mM (in 1mL DMSO)
Lornoxicam (CAS 70374-39-9) is an oxicam-class nonsteroidal anti-inflammatory drug (NSAID) that exerts its pharmacological effects primarily by potent inhibition of cyclooxygenase isoforms COX-1 and COX-2 with in vitro IC50 values of 5 nM and 8 nM respectively Studies in intact human cells and whole blood confirm its strong suppressive activity against both COX isoenzymes Additionally lornoxicam displays dose-dependent inhibition of nitric oxide formation (IC50 65 M) and reduction of IL-6 production in vitro Due to its robust COX inhibition and favorable pharmacokinetic profile lornoxicam is widely utilized as a research tool in studies investigating inflammation pain pathways and COX-mediated prostaglandin synthesis
Selleck Chemical LLC Brinzolamide S3178-1g
Brinzolamide (AL-4862) is a potent carbonic anhydrase II inhibitor with IC50 of 3 19 nM
Cayman Chemical BrInzolamIde 25mg
A selectve P receptor antagonst antagonzes the carbaprostacycln-nduced actvaton of human neuroblastoma adenylate cyclase blockng cyclc AMP accumulaton nhbts the bndng of trtated loprost to rodent neuroblastoma cells (K 3 nM)
Selleck Chemical LLC Lornoxicam S2047-10mg
Lornoxicam (Chlortenoxicam) is a non-steroidal COX-1/COX-2 inhibitor used as an anti-inflammatory drug to treat pain osteoarthritis and rheumatoid arthritis
Selleck Chemical LLC Lornoxicam S2047-50mg
Lornoxicam (Chlortenoxicam) is a non-steroidal COX-1/COX-2 inhibitor used as an anti-inflammatory drug to treat pain osteoarthritis and rheumatoid arthritis
Cayman Chemical BrInzolamIde 50mg
A selectve fluorescent probe for H2O2 detecton fluoresces upon perhydrolyss of the sulfonyl lnkage selectve for hydrogen peroxde over hydroxyl radcal tert-butyl hydroperoxde superoxde anon snglet oxygen and ntrates can be used as a probe for hydrogen peroxde n whole cell systems
BRINZOLAMIDE 50MG
Also available in 5 mg 10 mg 25 mg 100 mg 200 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Brinzolamide (AL-4862) is a Carbonic Anhydrase Inhibitor. The mechanism of action of brinzolamide is as a Carbonic Anhydrase Inhibitor. purity: 100%
Cayman Chemical BrInzolamIde 100mg
A thoester phospholpase substrate substrate for Type PLA2 enzymes such as porcne pancreatc bee venom and snake venom PLA2
AdipoGen Brinzolamide
Chemical. CAS 138890-62-7. Formula C12H21N3O5S3. MW 383.51. Synthetic. Brinzolamide is a potent inhibitor of carbonic anhydrases IC50=3.2nM and 45.3nM for CAII and CAIV, respectively that lowers intraocular pressure by locally inhibiting carbonic anhydrase in the ciliary processes and suppressing aqueous humor secretion. Animal studies have found that one week of twice-daily topical ocular treatment with 2% brinzolamide significantly reduced IOP and enhanced optic nerve head blood flow.
Sigma Aldrich Fine Chemicals Biosciences Brinzolamide >=98% (HPLC) | 138890-62-7 | MFCD08067749 | 10MG
Brinzolamide >=98% (HPLC) | Purity: >=98% (HPLC) | Mol Wt: 383.51 | 138890-62-7 | MFCD08067749 | 10MG
Brinzolamide 138890-62-7 10mM (in 1mL DMSO)
Brinzolamide (CAS 138890-62-7) is a potent and selective inhibitor of carbonic anhydrase II (CA II) with an IC50 of 3 19 nM and a Ki of 0 13 nM in vitro By inhibiting CA II brinzolamide disrupts the reversible hydration of carbon dioxide thereby reducing aqueous humor production and lowering intraocular pressure Demonstrated to have higher affinity and inhibitory efficacy for CA II compared to CA I and CA IV brinzolamide has been shown to significantly decrease intraocular pressure in animal models Additionally it is utilized in research settings to assess cerebral blood flow reserve as CA inhibition modulates tissue CO2 levels and consequent vasodilation
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