Thiophenes

Aobchem AOBCHEM

5001007882 2-METHYLTHIOPHENE-3-CARBONYL C

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Aobchem AOBCHEM

5001010543 METHYL 3-ISOPROPOXY-4-METHYLBE

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Aobchem AOBCHEM

5001010610 3-FLUORO-2-METHYL-6- METHYLTHI

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Aobchem AOBCHEM

5001016128 1- 3- TERT-BUTYL -5- METHYLTHI

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Aobchem AOBCHEM

5001020733 4-FLUORO-3- HYDROXY THIOPHEN-2

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Aobchem AOBCHEM

5001020818 5-ETHOXY-2-FLUORO-3- METHYLTHI

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Aobchem AOBCHEM

5001021176 4-BROMO-2-CHLOROBENZO B THIOPH

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Aobchem AOBCHEM

5001021254 4-CHLORO-3-FLUORO-2- METHYLTHI

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Aobchem AOBCHEM

5001021297 2-FLUORO-5-METHYL-3- METHYLTHI

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Apexbio Technology LLC Quinacrine 2HCl 69-05-6 10mM (in 1mL H2O)

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Quinacrine 2HCl (69-05-6) is an orally active small-molecule inhibitor targeting the NF- B signaling pathway It is designed to inhibit the NF- B cascade thereby downregulating pro-survival gene expression and promoting apoptotic pathways in tumor cells Quinacrine 2HCl exerts its biological activity primarily through inhibition of NF- B and activation of the p53-dependent apoptotic pathway In in vitro studies Quinacrine 2HCl demonstrates growth inhibition of multiple cancer cell lines with reported IC50 values generally in the low micromolar range depending on the specific cell model and experimental context Based on these pharmacological properties Quinacrine 2HCl holds research potential in investigating apoptosis regulatory mechanisms NF- B pathway involvement in cancer biology and preclinical evaluation of potential anticancer therapies

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Medchemexpress LLC 2-[2-(4-methoxy-2-pyridinyl)ethyl]-1H-imidazo[4,5-b]pyridine, dihydrochloride | 1216722-25-6 | MFCD11100187 | 99.6% | 327.21 g·mol⁻¹ | C14H16Cl2N4O | 5 MG

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BYK 191023 dihydrochloride is a selective inducible nitric-oxide synthase (iNOS) inhibitor used in in vitro and in vivo research to probe iNOS-mediated pathways. It is supplied as a solid research chemical with high purity and is characterized by a defined molecular formula and molecular weight.

• Selective inhibitor of inducible nitric-oxide synthase for mechanistic studies
• High purity (≈99.6%) for reproducible results
• Well-characterized molecular weight 327.21 g·mol⁻¹ and chemical formula C14H16Cl2N4O
• Solid powder form for convenient handling and formulation
• Storage recommendations available for both solid and solution states
• Available in small research quantities suitable for assay development

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Medchemexpress LLC DDP-38003 dihydrochloride | 1831167-98-6 | 99.3% | 423.38 | 100 MG

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DDP-38003 dihydrochloride is a novel, orally available inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1) with an IC50 of 84 nM. It exhibits in vivo efficacy after oral administration, determining a 62% increased survival in mouse leukemia models with evidence of KDM1A inhibition. The half-life of DDP-38003 is 8 hours. A significant dose-dependent increase of mice survival is obtained by DDP-38003 treatment. DDP-38003 is a potential oral anticancer agent.

• Novel, orally available inhibitor of KDM1A/LSD1
• IC50 of 84 nM against KDM1A
• More active in reducing colony forming ability and inducing differentiation of THP-1 cells compared to the 1R, 2S analogue
• Exhibits in vivo efficacy after oral administration
• Determines 62% increased survival in mouse leukemia models
• Half-life of 8 hours
• Potential oral anticancer agent
• Appearance: Solid, brown to reddish brown

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Medchemexpress LLC Prlx-93936 (dihydrochloride) | 1094210-96-4 | 10 MG

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Research-grade HIF-1α inhibitor provided as the dihydrochloride salt for in vitro research. Reported to inhibit HIF-1α and the activated Ras pathway; intended for use in anticancer pathway studies and compound screening. Molecular formula C21H26Cl2N4O2; molecular weight 437.36; CAS 1094210-96-4.

• Dihydrochloride salt, suitable for laboratory research.
• Reported HIF-1α inhibitory activity and Ras pathway inhibition.
• Supplied in small mg package sizes for assay and screening use.
• Molecular formula C21H26Cl2N4O2; molecular weight 437.36.
• CAS number 1094210-96-4 for unambiguous identification.

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Apexbio Technology LLC Dorsomorphin 2HCl 1219168-18-9 5mg

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Dorsomorphin 2HCl (CAS 1219168-18-9) is a small-molecule inhibitor targeting BMP signaling through selective blockade of BMP type I receptors ALK2 ALK3 and ALK6 It prevents phosphorylation of downstream effectors SMAD1/5/8 with an IC50 of approximately 0 47 mM Originally identified by zebrafish phenotypic screening as a disruptor of embryonic dorsoventral patterning Dorsomorphin has been employed to dissect BMP-regulated pathways in iron homeostasis significantly affecting hepcidin expression and iron metabolism in vitro and in vivo It is widely utilized in mechanistic studies of BMP function and signaling regulation

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Medchemexpress LLC Rimcazole dihydrochloride | 75859-03-9 | 100.0% | 394.38 | 25 MG

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Rimcazole dihydrochloride is a carbazole derivative that acts in part as a sigma (σ) receptor antagonist. It also binds with moderate affinity to the dopamine transporter and inhibits dopamine uptake. It can reduce locomotor activity and sensitization and can be used for cancer research.

• Acts as a sigma (σ) receptor antagonist
• Binds to the dopamine transporter
• Inhibits dopamine uptake
• Reduces locomotor activity and sensitization
• Can be used for cancer research

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