Thiophenes
Medchemexpress LLC 8-(((2r,5r)-5-amino-1,3-dioxan-2-yl)methyl)-6-(2-chloro-4-(3-fluoropyridin-2-yl)phenyl)-2-(methylami | 2750707-05-0 | 98.8% | C24H22ClFN6O3 | 10MG
MRIA9 is an ATP-competitive chemical probe that inhibits salt-inducible kinases (SIK1/2/3) and p21-activated kinases (PAK2/3), used in biochemical and cellular studies of SIK/PAK signaling. Reported in vitro IC50 values are 516 nM (SIK1), 180 nM (SIK2), and 127 nM (SIK3). The compound is supplied as a high-purity solid for research use.
Medchemexpress LLC SB 242084 dihydrochloride | 1049747-87-6 | MFCD02684417 | 98.1% | C21H21Cl3N4O2 | 10MG
SB 242084 dihydrochloride is a selective, high-affinity 5-HT2C receptor antagonist used in neuroscience research. It crosses the blood-brain barrier and is used to study serotonergic regulation of dopaminergic neurons, behavioral effects, and metabolic changes. Provided as a dihydrochloride salt and available in solution formats, it is intended for research use only.
- Selective 5-HT2C receptor antagonist
- High affinity (pKi = 9.0)
- Crosses the blood-brain barrier
- Suitable for in vitro and in vivo studies
- Available as solid salt and DMSO solution formats
- Intended for research use only
eMolecules Diethyl 2-aminothiophene-3,4-dicarboxylate | 104680-25-3 | MFCD08059079 | 1g
Ambeed | Diethyl 2-aminothiophene-3,4-dicarboxylate | 1g | 600837044 | A306442 | | 104680-25-3 | MFCD08059079 | 243.280 | C10H13NO4S
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Medchemexpress LLC NT1-O12B | 2739805-63-9 | 95.0% | C36H60N2O4S4 | 10MG
NT1-O12B is a neurotransmitter-derived lipidoid designed to enhance brain delivery of cargos that are normally impermeable to the blood-brain barrier when formulated into lipid nanoparticles. The compound is an oil with high purity and documented solubility and formulation protocols for in vitro and in vivo use.
- Enhances delivery across the blood-brain barrier.
- Compatible with lipid nanoparticle formulation.
- High purity (95.0%).
- Soluble in DMSO (200 mg/mL) for in vitro applications.
- Proven in vivo formulation protocols for suspension and clear solutions.
eMolecules Ambeed tert-Butyl (2-methylthiazol-4-yl)carbamate 100mg 837401996 A800522 0 000 848472-61-7 MFCD27923451 214 280 C9H14N2O2S
Ambeed tert-Butyl (2-methylthiazol-4-yl)carbamate 100mg 837401996 A800522 0 000 848472-61-7 MFCD27923451 214 280 C9H14N2O2S
eMolecules 2,3-Dichlorothiophene-5-sulfonamide | 256353-34-1 | MFCD00177161 | 25g
Oakwood Chemical | 2,3-Dichlorothiophene-5-sulfonamide | 25g | 537683755 | 032470 | | 256353-34-1 | MFCD00177161 | 232.090 | C4H3Cl2NO2S2
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![eMolecules 6-Isopropoxybenzo[d]thiazol-2-amine | 15850-81-4 | MFCD09755108 | 250mg](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502136977.JPG-250.jpg)
eMolecules 6-Isopropoxybenzo[d]thiazol-2-amine | 15850-81-4 | MFCD09755108 | 250mg
Ambeed | 6-Isopropoxybenzo[d]thiazol-2-amine | 250mg | 602850648 | A729740 | | 15850-81-4 | MFCD09755108 | 208.280 | C10H12N2OS
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![eMolecules Benzo[b]thiophene-6-carbaldehyde | 6386-80-7 | MFCD18451824 | 50mg](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502141402.JPG-250.jpg)
eMolecules Benzo[b]thiophene-6-carbaldehyde | 6386-80-7 | MFCD18451824 | 50mg
Ambeed | Benzo[b]thiophene-6-carbaldehyde | 50mg | 552547658 | A120837 | | 6386-80-7 | MFCD18451824 | 162.210 | C9H6OS
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Medchemexpress LLC Azido-PEG4-hydrazide-Boc | 1919045-01-4 | >98.0% | C16H31N5O7 | 100 MG
Azido-PEG4-hydrazide-Boc is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent containing an Azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules having Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. PROTACs exploit the intracellular ubiquitin-proteasome system to degrade target proteins, consisting of two different ligands connected by a linker: one for an E3 ubiquitin ligase and one for the target protein.
- PEG-based PROTAC linker
- Utilized in PROTAC synthesis
- Functions as a click chemistry reagent
- Contains an azide group
- Enables copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc)
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
Medchemexpress LLC Alexidine dihydrochloride | 1715-30-6 | 99.7% | 581.71 | 10 MG
Alexidine dihydrochloride is an anticancer agent that targets a mitochondrial tyrosine phosphatase, PTPMT1, in mammalian cells and causes mitochondrial apoptosis. It also has antifungal and antibiofilm activity against a diverse range of fungal pathogens.
- Anticancer agent targeting mitochondrial tyrosine phosphatase, PTPMT1.
- Causes mitochondrial apoptosis.
- Antifungal and antibiofilm activity against a diverse range of fungal pathogens.
- Displays activity against most Candida spp., including fluconazole-resistant isolates.
- Complete inhibition of filamentation or proliferation of imaged fungi.
- Able to decimate mature biofilms of Candida, Cryptococcus, and Aspergillus spp. at low concentrations.
- Inhibits fungal biofilm growth and viability in a murine biofilm model.
eMolecules 6-bromo-1-benzothiophen-2-amine | 739362-50-6 | MFCD17016086 | 1g
Pharmablock | 6-bromo-1-benzothiophen-2-amine | 1g | 551201457 | PB03430 | | 739362-50-6 | MFCD17016086 | 228.110 | C8H6BrNS
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