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Filtered Search Results
Medchemexpress LLC RP-1664 | 2980682-00-4 | 98.8% | 514.55 | 25 MG
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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RP-1664 is a selective and orally active PLK4 inhibitor with an IC50 of 3 nM. It demonstrates high selectivity over related kinases like AURKA/B and PLK1. This compound disrupts centriole biogenesis in cancer cells, leading to an accumulation of PLK4 and p21 protein. RP-1664 shows increased sensitivity in TRIM37-high-expressing cells or tumors and exhibits anti-tumor activity in breast cancer and neuroblastoma research.
- Selective and orally active PLK4 inhibitor.
- IC50 of 3 nM for PLK4.
- Exhibits exquisite selectivity over related kinases such as AURKA/B and PLK1.
- Disrupts centriole biogenesis in cancer cells.
- Leads to accumulation of PLK4 and p21 protein.
- Demonstrates increased sensitivity in TRIM37-high-expressing cells or tumors.
- Exhibits anti-tumor activity in breast cancer and neuroblastoma research.
- Appearance: Solid, White to off-white.
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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eMolecules 75178-96-0 | 1-Boc-amino-1,3-propanediamine | Advanced ChemBlocks | MFCD00210021 | 174.244 | C8H18N2O2 | 97.000 | CC(C)(C)OC(=O)NCCCN | 5g | 875074114
1-Boc-amino-1,3-propanediamine | Advanced ChemBlocks | 75178-96-0 | MFCD00210021 | 174.244 | C8H18N2O2 | 97.000 | CC(C)(C)OC(=O)NCCCN | 5g | 875074114
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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eMolecules EMOLECULES INC
5000482118 N-3-AMINOPROPYL-N-METHYL 25G
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eMolecules 111-40-0 | Diethylenetriamine | Oakwood Chemical | MFCD00008171 | 103.169 | C4H13N3 | 99.000 | NCCNCCN | 500g | 857187899
Diethylenetriamine | Oakwood Chemical | 111-40-0 | MFCD00008171 | 103.169 | C4H13N3 | 99.000 | NCCNCCN | 500g | 857187899
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eMolecules 110-91-8 | Morpholine purified by distillation from glass | Oakwood Chemicals | MFCD00005972 | 87.122 | C4H9NO | 99.000 | C1COCCN1 | 25g | 480151580
Morpholine purified by distillation from glass | Oakwood Chemicals | 110-91-8 | MFCD00005972 | 87.122 | C4H9NO | 99.000 | C1COCCN1 | 25g | 480151580
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Cayman Chemical Tranylcypromine hydrochlorid
An irreversible, mechanism-based inhibitor of LSD1 (IC50 = 20.7 µM); irreversibly inhibits MAO-A and MAO-B (IC50s = 2.3 and 0.95 µM, respectively); PCPA inhibits nucleosomal demethylation of H3K4 (IC50 = <2 µM); induces EpiSCs to convert to more undifferentiated state but requires inhibitors of ALK5, MEK, FGFR, and GSK3 for full conversion to pluripotent mESCs; decreases proliferation of neural progenitors in the hippocampal dentate gyrus in adult mice at 10 mg/kg for ten days; decreases the time juvenile rats spend immobile in the forced swim test at 0.4-10 mg/kg
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eMolecules 114841-52-0 | 3-AMINOPYRROLIDINE-2,5-DIONE HCL | AstaTech150.560 | C4H7ClN2O2 | 95.000 | Cl.NC1CC(=O)NC1=O | 0.1g | 603096903
3-AMINOPYRROLIDINE-2,5-DIONE HCL | AstaTech | 114841-52-0150.560 | C4H7ClN2O2 | 95.000 | Cl.NC1CC(=O)NC1=O | 0.1g | 603096903
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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eMolecules 1177339-95-5 | 2-Isopropylpiperidine hydrochloride | Combi-Blocks | MFCD07357628 | 163.690 | C8H18ClN | 96.000 | Cl.CC(C)C1CCCCN1 | 1g | 205406222
2-Isopropylpiperidine hydrochloride | Combi-Blocks | 1177339-95-5 | MFCD07357628 | 163.690 | C8H18ClN | 96.000 | Cl.CC(C)C1CCCCN1 | 1g | 205406222
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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eMolecules 17583-40-3 | 2-(METHYLAMINO)BENZONITRILE | AstaTech | MFCD11155692 | 132.166 | C8H8N2 | 95.000 | CNc1ccccc1C#N | 1g | 449756444
2-(METHYLAMINO)BENZONITRILE | AstaTech | 17583-40-3 | MFCD11155692 | 132.166 | C8H8N2 | 95.000 | CNc1ccccc1C#N | 1g | 449756444
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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eMolecules 40896-74-0 | 3-(AMINOMETHYL)BENZONITRILE HCL | AstaTech | MFCD06797955 | 168.620 | C8H9ClN2 | 95.000 | Cl.NCc1cccc(c1)C#N | 5g | 449772995
3-(AMINOMETHYL)BENZONITRILE HCL | AstaTech | 40896-74-0 | MFCD06797955 | 168.620 | C8H9ClN2 | 95.000 | Cl.NCc1cccc(c1)C#N | 5g | 449772995
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eMolecules 1311254-39-3 | Ethyl N-Boc-isoindoline-4-carboxylate | Combi-Blocks | MFCD19382496 | 291.347 | C16H21NO4 | 95.000 | CCOC(=O)c1cccc2CN(Cc12)C(=O)OC(C)(C)C | 1g | 448009826
Ethyl N-Boc-isoindoline-4-carboxylate | Combi-Blocks | 1311254-39-3 | MFCD19382496 | 291.347 | C16H21NO4 | 95.000 | CCOC(=O)c1cccc2CN(Cc12)C(=O)OC(C)(C)C | 1g | 448009826
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Chem-Impex International, Inc. N,N'-Bis(3-aminopropyl)-1,4-butanediamine | MFCD00008215 | 1G
N,N'-Bis(3-aminopropyl)-1,4-butanediamine, MFCD00008215, 1G
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Medchemexpress LLC Melk-8a hydrochloride | 2096992-20-8 | 99.3% | 469.02 | C25H33ClN6O | 5 MG
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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MELK-8a hydrochloride is a potent research-use small-molecule inhibitor of maternal embryonic leucine zipper kinase (MELK) with an IC50 of 2 nM. It is supplied as a light yellow to yellow solid with high purity, and is intended for in vitro research applications only. Chemical properties include formula C25H33ClN6O and molecular weight 469.02. Recommended storage is 4°C sealed; in solvent store at -80°C for long-term stability.
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Medchemexpress LLC MEDCHEMEXPRESS LLC
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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5000284792 2-ETHYLHEXYL 2 3 4 5 1MG
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Medchemexpress LLC RP-1664 | 2980682-00-4 | 98.77% | 514.55 | 50 MG
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More
RP-1664 is a selective and orally active PLK4 inhibitor with an IC50 of 3 nM. It demonstrates exquisite selectivity over related kinases, including AURKA/B and PLK1. It disrupts centriole biogenesis in cancer cells, leading to an accumulation of PLK4 and p21 protein. It shows increased sensitivity in TRIM37-high-expressing cells or tumors and exhibits anti-tumor activity in breast cancer and neuroblastoma research.
- Selective and orally active PLK4 inhibitor.
- IC50 of 3 nM for PLK4.
- Exquisite selectivity over AURKA/B and PLK1.
- Disrupts centriole biogenesis in cancer cells.
- Leads to accumulation of PLK4 and p21 protein.
- Increased sensitivity in TRIM37-high-expressing cells or tumors.
- Exhibits anti-tumor activity in breast cancer and neuroblastoma research.
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
Learn More