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- (1)
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Filtered Search Results
Chemscene CHEMSCENE
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5000575536 TERT-BUTYL 3-OXOCYCLOBUTAN 25G
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5000577813 4-DEOXYPYRIDOXINE HYDROCHLO 1G
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5000579779 PCPA METHYL ESTER HYDROCHLO 5G
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Medchemexpress LLC Slm6031434 hydrochloride | 1897379-34-8 | 99.1% | 1 MG
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A selective sphingosine kinase 2 (SphK2) inhibitor supplied as the hydrochloride salt for research use. Solid, high-purity material characterized by molecular formula C22H31ClF3N5O2 and molecular weight 489.96 Da.
- Selective sphingosine kinase 2 inhibitor for biochemical and cellular studies.
- Hydrochloride salt form, supplied as a solid powder.
- High purity (reported 99.1%), suitable for research applications.
- Soluble in water at approximately 40 mg/mL with ultrasonic warming if required.
- Recommended storage: long-term in solvent at -80°C, short-term at -20°C, sealed and away from moisture.
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Medchemexpress LLC Melitracen hydrochloride | 10563-70-9 | MFCD00242905 | >98.0% | 327.89 | C21H26ClN | 200 MG
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Melitracen hydrochloride is a research-grade tricyclic antidepressant hydrochloride salt supplied for laboratory use. It is used in pharmacological studies of monoamine neurotransmitter uptake and serotonergic (5-HT) receptor pathways. Provided as a solid for in vitro and preclinical research; not for human or veterinary use.
- Tricyclic antidepressant hydrochloride salt.
- Molecular formula C21H26ClN.
- Molecular weight 327.89.
- Purity >98.0% (HPLC).
- Available as a solid powder, commonly in 200 MG quantities.
- For research use only; not for human or veterinary use.
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Medchemexpress LLC 1-Piperazinebutanol, α-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-, hydrochloride (1:1) | 105565-55-7 | 98.0% | 384.85 | 50 MG
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BMY-14802 hydrochloride is a potent agonist of 5-HT1A and adrenergic α1 receptors, known for its antipsychotic effects.
- Appearance: white to off-white solid.
- Storage: -20°C, sealed storage, away from moisture. In solvent: -80°C, 6 months; -20°C, 1 month.
- ¹H NMR spectrum consistent with structure.
- MS consistent with structure.
- Product tested and complies with given specifications.
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Medchemexpress LLC Ponatinib hydrochloride | 1114544-31-8 | 99.8% | 569.02 | 25 MG
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Ponatinib hydrochloride, also known as AP24534 hydrochloride, is an orally active multi-targeted kinase inhibitor. It inhibits various kinases with IC50s including 0.37 nM for Abl, 1.1 nM for PDGFRα, 1.5 nM for VEGFR2, 2.2 nM for FGFR1, and 5.4 nM for Src.
- Purity of 99.76%
- CAS number: 1114544-31-8
- Molecular weight: 569.02
- Appears as an off-white to light yellow solid
- Soluble in DMSO at 25 mg/mL
- Targets Bcr-Abl, FGFR, PDGFR, VEGFR, Src, and Autophagy pathways
- Store at 4°C, sealed, away from moisture; in solvent, store at -80°C for 6 months or -20°C for 1 month
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Medchemexpress LLC PhiKan 083 hydrochloride | 1050480-30-2 | 99.3% | 274.79 | 10 MG
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PhiKan 083 hydrochloride is a carbazole derivative designed to bind to the surface cavity and stabilize the Y220C p53 mutant, with a binding affinity (Kd) of 167 μM. It effectively slows down the thermal denaturation rate of the p53 mutant and has been shown to reduce cell viability in engineered variants of Ln229 cells. When used in combination with NSC 123127, it enhances pro-apoptotic activity across multiple Ln229 cell variants.
- Binds to and stabilizes Y220C p53 mutant
- Slows down thermal denaturation rate of p53 mutant
- Reduces cell viability in engineered variants of Ln229 cells
- Enhances pro-apoptotic activity when combined with NSC 123127
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Medchemexpress LLC Cl-amidine hydrochloride | 1373232-26-8 | MFCD22201084 | 99.8% | 347.24 | C14H20Cl2N4O2 | 1 ML
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Cl-amidine hydrochloride is an orally active peptidylarginine deiminase (PAD) inhibitor used in biochemical, cellular, and in vivo research to block protein citrullination and probe PAD-related pathways.
- Inhibits PAD1, PAD3, and PAD4 with reported IC50 values of 0.8 μM, 6.2 μM, and 5.9 μM.
- Available as a 10 mM solution in DMSO or as solid quantities for formulation flexibility.
- High purity (~99.8%) suitable for biochemical and cellular assays.
- Demonstrated activity in cell apoptosis and neutrophil extracellular trap formation assays.
- Shows efficacy in murine models of colitis and sepsis in published studies.
- Provided supporting documents: data sheet, SDS, COA, HNMR, RP-HPLC, and LCMS.
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Medchemexpress LLC Aptiganel hydrochloride | 137160-11-3 | 99.8% | 339.86 g·mol⁻1 | C20H22ClN3 | 5 MG
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Aptiganel hydrochloride is the hydrochloride salt of aptiganel, a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist with reported neuroprotective activity. It is provided as a purified research chemical for studies of excitotoxicity and NMDA receptor-mediated signaling.
- Non-competitive NMDA receptor antagonist
- Reported neuroprotective activity
- Hydrochloride salt form
- High purity (99.8%)
- Suitable for in vitro and in vivo research
- Molecular weight 339.86 g·mol⁻1
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Medchemexpress LLC BMY-14802 hydrochlo | 10 MG
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BMY-14802 hydrochlo | 10 MG
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Medchemexpress LLC Simufilam hydrochloride (PTI-125 hydrochloride) | 2480226-07-9 | 99.9% | 295.81 | 25 MG
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Simufilam hydrochloride (PTI-125 hydrochloride) is an orally active FLNA modulator. It restores NMDAR signaling and Arc expression. It inhibits overactive mTOR signaling by restoring the normal conformation of FLNA, improves insulin sensitivity, reduces Aβ42-induced neuroinflammation, and tau protein hyperphosphorylation. This product can be used for research related to Alzheimer's disease.
- Reduces FLNA-α7nAChR/TLR4 associations and dissociates Aβ42-α7nAChR complexes.
- Restores α7nAChR/NMDAR/IR function and NMDAR signaling and arc expression in human AD brain slices.
- Decreases tau phosphorylation, Aβ42 aggregates, and inflammatory cytokines in mouse models.
- Improves NMDAR/IR function, synaptic plasticity, spatial/working memory, and nesting behavior in 3xTg AD mice.
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Medchemexpress LLC Imidapril hydrochloride | 89396-94-1 | 99.91% | 5 MG
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Imidapril hydrochloride (TA-6366) is an orally active angiotensin-converting enzyme (ACE) and MMP-9 inhibitor. It suppresses the conversion of angiotensin I to angiotensin II, which reduces total peripheral resistance and systemic blood pressure. It can be used for research on hypertension, type 1 diabetic nephropathy, and chronic heart failure.
- Orally active ACE and MMP-9 inhibitor
- Suppresses the conversion of angiotensin I to angiotensin II
- Reduces total peripheral resistance and systemic blood pressure
- Applicable for research in hypertension, type 1 diabetic nephropathy, and chronic heart failure
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Medchemexpress LLC GW806742X hydrochloride | 98.3% | 610.01 | 25 MG
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GW806742X hydrochloride is an ATP mimetic and a potent MLKL inhibitor that binds the MLKL pseudokinase domain with a Kd of 9.3 μM. It also exhibits activity against VEGFR2 (IC50=2 nM). This compound retards MLKL membrane translocation and inhibits necroptosis. It is for research use only.
- Potent MLKL inhibitor (Kd of 9.3 μM)
- Active against VEGFR2 (IC50=2 nM)
- Retards MLKL membrane translocation
- Inhibits necroptosis
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Medchemexpress LLC Sovesudil hydrochloride | 2984963-50-8 | 99.5% | 443.90 | 25 MG
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Sovesudil (PHP-201) hydrochloride is a potent, ATP-competitive, locally acting Rho kinase (ROCK) inhibitor with IC50s of 3.7 and 2.3 nM for ROCK-I and ROCK-II, respectively. It lowers intraocular pressure (IOP) without inducing hyperemia.
- Potent, ATP-competitive, locally acting Rho kinase (ROCK) inhibitor
- IC50s of 3.7 nM for ROCK-I and 2.3 nM for ROCK-II
- Lowers intraocular pressure (IOP) without inducing hyperemia
- Induces altered cellular behavior of human trabecular meshwork (HTM) cells in vitro
- Effectively reduces IOP in ocular normotensive and acute hypertensive rabbits without causing distinct hyperemia in vivo
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