Alcohols and polyols
Medchemexpress LLC Enerisant hydrochloride | 1152749-07-9 | 95.0% | 10 MG
Enerisant hydrochloride is the hydrochloride salt of a potent, selective histamine H3 receptor antagonist/inverse agonist supplied as a research reagent for preclinical and in vitro studies. It is provided as a solid for laboratory use and is not intended for human or veterinary applications.
- Potent histamine H3 receptor antagonist/inverse agonist.
- Hydrochloride salt form for improved stability and solubility.
- CAS number 1152749-07-9 and molecular formula C22H31ClN4O3.
- Molecular weight 434.96 g·mol-1.
- Typical purity 95.0%.
- Packaged as a 10 mg solid; store frozen per supplier guidance.
Medchemexpress LLC Enerisant hydrochloride | 1152749-07-9 | 98.7% | 434.96 | 5 MG
Enerisant hydrochloride | 1152749-07-9 | 98.7% | 434.96 | 5 MG
Medchemexpress LLC Simufilam hydrochloride | 2480226-07-9 | 99.9% | 295.81 | 10 MG
Simufilam hydrochloride (PTI-125 hydrochloride) is an orally active FLNA modulator. It restores NMDAR signaling and Arc expression, inhibits overactive mTOR signaling by restoring the normal conformation of FLNA, improves insulin sensitivity, and reduces Aβ42-induced neuroinflammation and tau protein hyperphosphorylation. It can be used for research of Alzheimer's disease.
- Acts as an orally active FLNA modulator
- Restores NMDAR signaling and Arc expression
- Inhibits overactive mTOR signaling by restoring normal FLNA conformation
- Improves insulin sensitivity
- Reduces Aβ42-induced neuroinflammation and tau protein hyperphosphorylation
- Useful for Alzheimer's disease research
Medchemexpress LLC Simufilam hydrochloride (PTI-125 hydrochloride) | 2480226-07-9 | 99.9% | 295.81 | 25 MG
Simufilam hydrochloride (PTI-125 hydrochloride) is an orally active FLNA modulator. It restores NMDAR signaling and Arc expression. It inhibits overactive mTOR signaling by restoring the normal conformation of FLNA, improves insulin sensitivity, reduces Aβ42-induced neuroinflammation, and tau protein hyperphosphorylation. This product can be used for research related to Alzheimer's disease.
- Reduces FLNA-α7nAChR/TLR4 associations and dissociates Aβ42-α7nAChR complexes.
- Restores α7nAChR/NMDAR/IR function and NMDAR signaling and arc expression in human AD brain slices.
- Decreases tau phosphorylation, Aβ42 aggregates, and inflammatory cytokines in mouse models.
- Improves NMDAR/IR function, synaptic plasticity, spatial/working memory, and nesting behavior in 3xTg AD mice.