Organic disulfides
Medchemexpress LLC NX-2127 | 2416131-46-7 | C39H45N9O5 | 500 MG
Zelebrudomide (NX-2127) is an orally active PROTAC degrader that targets Bruton's Tyrosine Kinase (Btk). It inhibits the proliferation of BTKC481S mutant TMD8 cells more effectively than Ibrutinib. In vivo, it demonstrates potent degradation of BTK in cynomolgus monkeys and leads to superior tumor growth inhibition in both WT TMD8 and C481S mutant xenograft models in mice.
- Inhibits proliferation of BTKC481S mutant TMD8 cells
- Catalyzes the degradation of Ikaros (IKZF1) and Aiolos (IKZF3)
- Stimulates T cell activation and increases IL-2 production
- Demonstrates potent degradation of BTK in cynomolgus monkeys
- Leads to superior tumor growth inhibition in xenograft models in mice
Medchemexpress LLC PROTAC degrader targeting Bruton's tyrosine kinase (BTK) | 2416131-46-7 | 99.7% | 719.83 | C39H45N9O5 | 10 MG
NX-2127 is an orally bioavailable PROTAC degrader that targets Bruton's tyrosine kinase (BTK). It induces proteasomal degradation of BTK, shows activity against BTK C481S resistance mutants, degrades IKZF1 and IKZF3 transcription factors, and has demonstrated cellular and in vivo preclinical activity while promoting T cell activation and IL-2 production.
- Orally bioavailable PROTAC degrader of BTK.
- Induces proteasomal degradation of BTK and reduces BTK signaling.
- Active against BTK C481S resistance mutants in cellular models.
- Degrades IKZF1 and IKZF3, providing immunomodulatory effects.
- Stimulates T cell activation and increases IL-2 production in primary human T cells.
- Demonstrated efficacy in preclinical in vivo models.
Chem-Impex International, Inc. 3-(2-Pyridyldithio)propionic acid N-hydroxyuccinimide ester | 68181-17-9 | MFCD00009636 | 250MG
3-(2-Pyridyldithio)propionic acid N-hydroxyuccinimide ester, 68181-17-9, MFCD00009636, 250MG
Cambridge Isotope Laboratories Dicyclohexyl phthalate (ring-1 2-13C2 dicarboxyl-13C2 99%) 100 ug/mL in nonane 1 2 mL
Dicyclohexyl phthalate (ring-1 2-13C2 dicarboxyl-13C2 99%) 100 ug/mL in nonane 1 2 mL
Medchemexpress LLC N N-Dicyclohexyl-2-b 25g
N N-Dicyclohexyl-2-benzothiazolesulfenamide is a compound with reproductive and developmental toxicity that can affect body weight gain reproductive organ weight and multiple reproductive and developmental indicators in rats
Medchemexpress LLC NX-2127 | 2416131-46-7 | C39H45N9O5 | 1 G
NX-2127 | 2416131-46-7 | C39H45N9O5 | 1 G
Medchemexpress LLC Captopril disulfide | 64806-05-9 | MFCD08063643 | 99.3% | 432.55 | C18H28N2O6S2 | 5MG
Captopril disulfide is the symmetrical disulfide metabolite of the ACE inhibitor captopril, provided as a research-grade analytical standard for studies of angiotensin-converting enzyme inhibition and antihypertensive drug metabolism. Molecular formula C18H28N2O6S2, molecular weight 432.55, CAS 64806-05-9.
- High reported purity (99.29%).
- Analytical standard for metabolite and pharmacokinetic studies.
- Applicable to ACE activity and antihypertensive research.
- Available in milligram-scale pack sizes suitable for small-scale experiments.
- Stable white solid with defined molecular identity.
eMolecules 2645-08-1 | Ambeed | Bz-Arg-OEt.HCl | 5g | 525085449 | A168972 | MFCD00012579 | 342.82 | C15H23ClN4O3
AstaTech | ETHYL 4-BROMO-22-DIMETHYL-3-OXOBUTANOATE | 0.25g | 296377431 | AB7147 | 95.000 | 63891-88-3 | MFCD16620938 | 237.093 | C8H13BrO3
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