Organic disulfides
Medchemexpress LLC NX-2127 | 2416131-46-7 | C39H45N9O5 | 500 MG
Zelebrudomide (NX-2127) is an orally active PROTAC degrader that targets Bruton's Tyrosine Kinase (Btk). It inhibits the proliferation of BTKC481S mutant TMD8 cells more effectively than Ibrutinib. In vivo, it demonstrates potent degradation of BTK in cynomolgus monkeys and leads to superior tumor growth inhibition in both WT TMD8 and C481S mutant xenograft models in mice.
- Inhibits proliferation of BTKC481S mutant TMD8 cells
- Catalyzes the degradation of Ikaros (IKZF1) and Aiolos (IKZF3)
- Stimulates T cell activation and increases IL-2 production
- Demonstrates potent degradation of BTK in cynomolgus monkeys
- Leads to superior tumor growth inhibition in xenograft models in mice
Medchemexpress LLC PROTAC degrader targeting Bruton's tyrosine kinase (BTK) | 2416131-46-7 | 99.7% | 719.83 | C39H45N9O5 | 10 MG
NX-2127 is an orally bioavailable PROTAC degrader that targets Bruton's tyrosine kinase (BTK). It induces proteasomal degradation of BTK, shows activity against BTK C481S resistance mutants, degrades IKZF1 and IKZF3 transcription factors, and has demonstrated cellular and in vivo preclinical activity while promoting T cell activation and IL-2 production.
- Orally bioavailable PROTAC degrader of BTK.
- Induces proteasomal degradation of BTK and reduces BTK signaling.
- Active against BTK C481S resistance mutants in cellular models.
- Degrades IKZF1 and IKZF3, providing immunomodulatory effects.
- Stimulates T cell activation and increases IL-2 production in primary human T cells.
- Demonstrated efficacy in preclinical in vivo models.
eMolecules 108641-82-3 | Medchem Express | DL-Homocystine-33334444-d8 | 5mg | 771359132 | HY-W009390S | MFCD00209738 | 276.39 | C8H16N2O4S2
Ambeed | 2-Fluoro-3-(trifluoromethoxy)benzoic acid | 1g | 600839228 | A390619 | 1159512-62-5 | MFCD12026477 | 224.111 | C8H4F4O3
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eMolecules Building Block Tool
Medchemexpress LLC CSTSMLKAC (disulfide) | 99.3% | 941.15 | 10 MG
CSTSMLKAC (peptide 2) is a cyclic 9 amino acid sequence that mimics endogenous peptide sequences. CSTSMLKAC homes to cardiomyocytes in the ischemic myocardium.
- Cyclic 9 amino acid sequence
- Mimics endogenous peptide sequences
- Homes to cardiomyocytes in the ischemic myocardium
Selleck Chemical LLC NX-2127-E1381-100MG
NX-2127 is a unique potent inhibitor of BTK that prevents its functions by catalyzing the ubiquitylation and proteasomal degradation of BTK rather than via direct binding NX-2127 stimulates T cell activation and increases IL-2 production in primary human T Cells
Medchemexpress LLC Dipropyl disulfide | 629-19-6 | MFCD00009378 | 99.3% | 150.31 g/mol | C6H14S2 | 1 G
Dipropyl disulfide is an organosulfur compound supplied as a high-purity research standard for biochemical and metabolic studies, analytical reference work, and assay development. It is offered in liquid and ready-to-use solution formats for convenient laboratory handling.
- High purity (99.3%).
- Molecular formula C6H14S2; molecular weight 150.31 g/mol.
- Available as 1 G liquid and larger pack sizes; also as 10 mM 1 mL in DMSO solutions.
- Storage: pure form -20°C (up to 3 years); in solvent -80°C (6 months).
- Suitable for metabolic studies and analytical reference use.
Medchemexpress LLC 1,2-Benzenedicarboxylic acid, 1,2-dicyclohexyl ester | 84-61-7 | ≥97.0% | 330.42 | 25 G
Dicyclohexyl phthalate (DCHP) can be used as a plasticizer. It is a biological material or organic compound widely used in life science research.
- Can be used as a plasticizer.
- A biological material or organic compound widely used in life science research.
Chem-Impex International, Inc. 3-(2-Pyridyldithio)propionic acid N-hydroxyuccinimide ester | 68181-17-9 | MFCD00009636 | 250MG
3-(2-Pyridyldithio)propionic acid N-hydroxyuccinimide ester, 68181-17-9, MFCD00009636, 250MG
Selleck Chemical LLC NX-2127-E1381-5MG
NX-2127 is a unique potent inhibitor of BTK that prevents its functions by catalyzing the ubiquitylation and proteasomal degradation of BTK rather than via direct binding NX-2127 stimulates T cell activation and increases IL-2 production in primary human T Cells
Cambridge Isotope Laboratories Dicyclohexyl phthalate (ring-1 2-13C2 dicarboxyl-13C2 99%) 100 ug/mL in nonane 1 2 mL
Dicyclohexyl phthalate (ring-1 2-13C2 dicarboxyl-13C2 99%) 100 ug/mL in nonane 1 2 mL
Medchemexpress LLC N N-Dicyclohexyl-2-b 25g
N N-Dicyclohexyl-2-benzothiazolesulfenamide is a compound with reproductive and developmental toxicity that can affect body weight gain reproductive organ weight and multiple reproductive and developmental indicators in rats
Medchemexpress LLC NX-2127 | 2416131-46-7 | C39H45N9O5 | 1 G
NX-2127 | 2416131-46-7 | C39H45N9O5 | 1 G
Medchemexpress LLC Captopril disulfide | 64806-05-9 | MFCD08063643 | 99.3% | 432.55 | C18H28N2O6S2 | 5MG
Captopril disulfide is the symmetrical disulfide metabolite of the ACE inhibitor captopril, provided as a research-grade analytical standard for studies of angiotensin-converting enzyme inhibition and antihypertensive drug metabolism. Molecular formula C18H28N2O6S2, molecular weight 432.55, CAS 64806-05-9.
- High reported purity (99.29%).
- Analytical standard for metabolite and pharmacokinetic studies.
- Applicable to ACE activity and antihypertensive research.
- Available in milligram-scale pack sizes suitable for small-scale experiments.
- Stable white solid with defined molecular identity.