Sulfoxides
Medchemexpress LLC N'-(3-acetylphenyl)-N-(3-(2-methoxyethyl)-2,4-dioxo-1-(2-(piperidin-1-yl)ethyl)-1,2,3,4-tetrahydroquinazolin | 2946701-09-1 | 99.3% | 507.58 g/mol | C27H33N5O5 | 10 MG
COP1-ATGL modulator 1 is an orally active small-molecule research reagent that modulates the COP1-ATGL pathway. It increases ATGL protein expression, reduces ATGL and COP1 ubiquitination, and diminishes lipid accumulation in hepatocytes at nanomolar concentrations. Supplied as a white to off-white solid with high purity and defined storage recommendations for powder and solution.
- Orally active modulator of COP1-ATGL signaling.
- Increases ATGL protein expression at nanomolar concentrations.
- Reduces ATGL and COP1 ubiquitination in cellular assays.
- High purity suitable for research applications.
- Stable solid with recommended low-temperature storage.
Medchemexpress LLC GLP-1R modulator C16 | 875005-43-9 | 98.7% | C21H26ClFN2O3 | 10MM/1ML
GLP-1R modulator C16 is an allosteric modulator that enhances GLP-1 binding to GLP-1R via a transmembrane site.
- Enhances GLP-1 binding to GLP-1R
- Operates via a transmembrane site
- Purity of 98.7%
Medchemexpress LLC CXCR7 modulator 2 | 2227426-37-9 | 98.71% | 522.68 | 1 ML
CXCR7 modulator 2 is a modulator of C-X-C Chemokine Receptor Type 7 (CXCR7), with a Ki of 13 nM. It is for research use only and not sold to patients. This modulator offers protection against cardiac injury.
- Potent CXCR7-binding affinity (Ki=13 nM).
- β-arrestin activity (EC50=11 nM).
- Improved selectivity in the GPCR panel.
- Improved therapeutic index in the hERG patch-clamp assay.
- Moderate to high in vitro turnover in NADPH-supplemented mouse-liver microsomes (MLM, 93 μL/min/mg) and hepatocytes (28 μL/min per million cells).
- Good aqueous solubility.
- Rapidly absorbed with a mean maximal plasma concentration (Cmax) of 682 ng/mL at 0.25 h (Tmax).
- Reduces cardiac fibrosis in an isoproterenol-induced cardiac injury model in mice.
Medchemexpress LLC Mutant p53 modulator-1 | 2746371-35-5 | 99.9% | C27H32F4N8O2 | 10MG
Mutant p53 modulator-1 is a small-molecule research reagent reported to modulate mutant p53 and to reduce progression of cancers harboring p53 mutations. It is supplied as a powder for laboratory research and includes stability instructions for storage and handling.
- High purity: 99.9% suitable for analytical and biological studies.
- Defined chemical formula: C27H32F4N8O2 for unambiguous identification.
- Documented stability: powder stable at -20°C for long-term storage.
- Reported activity against mutant p53 to support targeted cancer research.
- Intended for research use only, not for human or clinical use.
Cayman Chemical AM630 Other Receptor Modulator
An inverse agonist at CB2 and partial agonist at CB1 receptors; binds selectively to CB2 over CB1 receptors (Kis = 31.2 and 5,152 nM, respectively); blocks the antinociceptive effects of cannabinoids; decreases proliferation and induces cell cycle arrest in renal cell carcinoma cells
Medchemexpress LLC Yk-2168 | 2571068-74-9 | 98.1% | 315.80 | 1 ML
YK-2168 is a potent and selective CDK9 inhibitor (IC50 of 5.9 nM) that targets the pS2-RNA Pol II C-terminal domain. It induces apoptosis, suppresses CDK9-regulated genes like MYC and Mcl1, and inhibits tumor growth in CDX mice models. This compound is suitable for cancer research, particularly leukemia.
- Potent and selective CDK9 inhibitor (IC50 of 5.9 nM).
- Induces apoptosis and suppresses CDK9-regulated genes.
- Inhibits tumor growth in CDX mice models (80% inhibition at 10 mg/kg).
- Highly selective over CDK1 and CDK2, with no hERG channel inhibition up to 30 μM.
- Reduces pS2-RNA Pol II CTD levels and upregulates cleaved caspase 3.
- Demonstrates good safety in vivo with no significant body weight changes.
Medchemexpress LLC Sulindac sulfone | 59973-80-7 | 98.1% | 5 MG
Sulindac sulfone is an mTORC1 pathway inhibitor and a metabolite of Sulindac. It inhibits colon cancer cell growth and induces cell cycle arrest. Sulindac sulfone is utilized in cancer research.
- Cytotoxicity against human COLO320 cells after 72 hrs by WST-1 assay (IC50 > 200 μM)
- Cytotoxicity against human MIAPaCa2 cells after 72 hrs by WST-1 assay (IC50 > 200 μM)
Medchemexpress LLC Nourseothricin (sulfate) | 96736-11-7 | 87.3% | 250 MG
Nourseothricin sulfate is a broad-spectrum antibiotic that inhibits protein biosynthesis in prokaryotic cells and strongly suppresses the growth of eukaryotes. It targets the outer membrane of Gram-negative bacteria and serves as a selective marker for various organisms, including bacteria, yeast, filamentous fungi, and plant cells.
- Broad-spectrum antibiotic
- Targets outer membrane of Gram-negative bacteria
- Serves as a selective marker for Fonsecaea pedrosoi
- Inhibits protein biosynthesis in prokaryotic cells
- Strongly suppresses growth of eukaryotes, such as fungi
- Sensitizes resistant Escherichia coli strains by eliminating outer membrane resistance
- Mixture of several Streptothricins (primarily D and F)
- Can create channels in the outer membrane
Medchemexpress LLC (E/Z)-Sulindac sulfide | 32004-67-4 | MFCD00869764 | 99.88% | 250 MG
(E/Z)-Sulindac sulfide is a potent γ-secretase modulator (GSM) that selectively reduces Aβ42 production in favor of shorter Aβ species. It can be used for researching Alzheimer's disease.
- Potent γ-secretase modulator (GSM).
- Selectively reduces Aβ42 production.
- Useful for Alzheimer's disease research.
Medchemexpress LLC GLP-1R modulator C5 | 421578-93-0 | 99.8% | C24H21NO3 | 100 MG
GLP-1R modulator C5 is an allosteric modulator that enhances GLP-1 binding to GLP-1R via a transmembrane site (EC50 1.59 ± 0.53 μM). It is intended for research use only.
- Allosteric modulator
- Enhances GLP-1 binding to GLP-1R
- Suitable for research applications
- Targets glucagon receptor (GCGR)
- Relevant for inflammation or immune system disease research
- Relevant for metabolic or endocrine disease research
- Relevant for digestive system disease research
Medchemexpress LLC YK-2168 | 2571068-74-9 | 98.05% | 315.80 | 50 MG
YK-2168 is a potent and selective CDK9 inhibitor with an IC50 of 5.9 nM. It inhibits the phosphorylation of the CDK9 substrate pS2-RNA Pol II C-terminal domain. YK-2168 induces apoptosis in tumor cells, suppresses the expression of CDK9-regulated genes such as MYC and Mcl1, and inhibits tumor growth in CDX mice models. This product can be used for cancer research, including leukemia.
- Potently inhibits purified CDK9 enzymatic activity
- Exhibits high selectivity over CDK1 and CDK2
- Inhibits proliferation of MV4-11 leukemia cells
- Induces dose-dependent inhibition of tumor growth in CDX mice models
- Suppresses CDK9-regulated gene expression
- Upregulates cleaved caspase 3, indicating induced apoptosis
- Maintains a good safety profile in vivo with no significant body weight changes
Medchemexpress LLC 3',4'-Tetramethylene-α-pyrrolidinobutiophenone (hydrochloride) | 2749504-65-0 | 99.9% | 307.86 | 50 MG
3',4'-Tetramethylene-α-pyrrolidinobutiophenone (hydrochloride) | 2749504-65-0 | 99.9% | 307.86 | 50 MG
Medchemexpress LLC Kv3.1 modulator 2 | 3035827-42-7 | 99.8% | 437.88 | 25 MG
Kv3.1 modulator 2 is a Kv3.1 channels modulator with an EC50 value of 68 nM. It is for research use only and not sold to patients. This compound is a solid, appearing white to off-white, and has detailed storage and solubility protocols for various applications.
- Kv3.1 channels modulator
- EC50 value of 68 nM
- Solid, white to off-white appearance
- Specific storage recommendations for powder and in solvent
- Detailed solubility information for in vitro and in vivo use
![Medchemexpress LLC 1-(2-(dimethylamino)ethyl)-3-(7-methylbenzo[1,2-d:3,4-d']bis(thiazole)-2-yl)urea | 1428729-63-8 | MFCD31619259 | 99.5% | 335.45 | C14H17N5OS2 | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000242667.png-250.jpg)
Medchemexpress LLC 1-(2-(dimethylamino)ethyl)-3-(7-methylbenzo[1,2-d:3,4-d']bis(thiazole)-2-yl)urea | 1428729-63-8 | MFCD31619259 | 99.5% | 335.45 | C14H17N5OS2 | 100 MG
RIG-1 modulator 1 is a small-molecule antiviral research compound described as "Compound of claim 13" that modulates RIG-1-related activity and is reported active against influenza virus, HBV, HCV, and HIV. It is supplied as a characterized solid for in vitro research and includes storage and stability information for powder and solutions.
- High purity: 99.5%.
- Appearance: solid, white to light yellow.
- Molecular formula: C14H17N5OS2; molecular weight: 335.45.
- Available in multiple pack sizes, including 100 mg.
- Storage recommendations: powder -20 °C (up to 3 years) or 4 °C (up to 2 years); in solvent -80 °C (up to 2 years).
- Intended for research use only; not for human or clinical use.
Medchemexpress LLC Elafibranor sulfoxide | 95.0% | 400.49 | C22H24O5S | 10 MG
Elafibranor sulfoxide is the sulfoxide metabolite of elafibranor supplied as a research-grade powder for in vitro and preclinical studies. It is intended for laboratory research use only and can be used to investigate PPAR-related pathways and metabolic disease models such as primary biliary cholangitis.
- Chemical formula C22H24O5S, molecular weight 400.49.
- Supplied as a powder; pack sizes include 10 MG.
- Purity (NMR): 95.0%.
- Target: PPAR; drug metabolite.
- Storage: powder -20°C for 3 years, 4°C for 2 years; in solvent -80°C for 6 months, -20°C for 1 month.
- Provided for research use only; not for human therapeutic use.