Sulfoxides
Cayman Chemical Sulindac sulfide
An active metabolite of sulindac; inhibits COX-1 and COX-2 (IC50s = 1.9 and 1.21 µM, respectively); inhibits aldose reductase (IC50 = 279 nM), blocking NADPH-dependent reduction of glucose to sorbitol, and reducing type 2 diabetic complications; inhibits colorectal cancer growth in vitro and in vivo
![Medchemexpress LLC N-{4-[(2-chloro-6-fluorobenzyl)oxy]-3-methoxybenzyl}-2-(morpholin-4-yl)ethanamine | 875005-43-9 | 99.6% | C21H26ClFN2O3 | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000259354.png-250.jpg)
Medchemexpress LLC N-{4-[(2-chloro-6-fluorobenzyl)oxy]-3-methoxybenzyl}-2-(morpholin-4-yl)ethanamine | 875005-43-9 | 99.6% | C21H26ClFN2O3 | 10MG
GLP-1R modulator C16 is a small-molecule allosteric modulator that enhances glucagon-like peptide-1 (GLP-1) binding to the GLP-1 receptor via a transmembrane site. Supplied for research use in solid form or as a DMSO solution, it is characterized by micromolar potency and high reported purity, and is intended for in vitro pharmacology and receptor modulation studies.
- Enhances GLP-1 binding to the GLP-1 receptor via a transmembrane allosteric site.
- Micromolar potency with EC50 ≈ 8.43 ± 3.82 μM.
- High purity suitable for biochemical and cell-based assays.
- Available as a solid and as a 10 mM solution in DMSO.
- Recommended storage: powder -20°C (long term) or 4°C; in solvent -80°C (long term).
Medchemexpress LLC Sirtuin modulator 1 | 2070015-26-6 | 99.85% | 606.20 | 100 MG
Sirtuin modulator 1 is a compound that acts as a modulator of SIRTl, a homolog of SIRT3. This compound has an EC1.5 of less than 1 μM and was extracted from patent WO 2010071853 A1, Compound No.4.
- Modulator of SIRTl, a homolog of SIRT3
- High purity of 99.85%
- Solid appearance, light yellow to yellow color
- Molecular weight of 606.20
- Soluble in DMSO at 12.5 mg/mL
Medchemexpress LLC Autotaxin modulator 1 | 1548743-69-6 | 99.4% | 10 MG
Autotaxin modulator 1 is an autotaxin (ATX) enzyme inhibitor, extracted from patent WO 2014018881 A1, Compound Example 12b. It is expected to be useful for researching demyelination due to injury or disease, as well as for researching proliferative disorders such as cancer.
- Autotaxin (ATX) enzyme inhibitor
- Useful for researching demyelination due to injury or disease
- Useful for researching proliferative disorders such as cancer
- For research use only
- Appears as a white to off-white solid
- Soluble in DMSO (100 mg/mL)
Apexbio Technology LLC Sulforaphane(Synonyms: Broccoli sulforaphane, DL-Sulforaphane, R-Sulforaphane, 1-Isothiocyanato-4-(methylsulfinyl)butane), 50mg, CAS: 4478-93-7.
Sulforaphane (CAS 4478-93-7) is a naturally occurring isothiocyanate abundantly found in vegetables especially broccoli It acts primarily through activation of the Keap1-Nrf2 signaling pathway enhancing cellular defense against oxidative and electrophilic stress Sulforaphane has demonstrated antiproliferative activity in vitro as shown by dose-dependent cell cycle arrest at G2/M and apoptosis induction in HT29 human colon carcinoma cells Such effects involve elevated cyclin A and B1 levels increased pro-apoptotic Bax expression mitochondrial cytochrome c release and poly(ADP-ribose) polymerase cleavage These properties make sulforaphane relevant for investigating cancer chemoprevention and cellular stress responses
Medchemexpress LLC YK-2168 | 2571068-74-9 | 98.1% | 315.80 | 5 MG
YK-2168 is a potent and selective CDK9 inhibitor with an IC50 of 5.9 nM. It inhibits phosphorylation of the CDK9 substrate pS2-RNA Pol II C-terminal domain. YK-2168 induces apoptosis in tumor cells, suppresses expression of CDK9-regulated genes such as MYC and Mcl1, and inhibits tumor growth in CDX mice models. It can be used for the research of cancer, such as leukemia.
- Potent and selective CDK9 inhibitor
- Induces apoptosis in tumor cells
- Suppresses expression of CDK9-regulated genes
- Inhibits tumor growth in CDX mice models
- Suitable for research in cancer, such as leukemia
Medchemexpress LLC MRGPRX2 modulator-1 | 2781839-42-5 | 99.03% | 459.39 | 5 MG
MRGPRX2 modulator-1 (example 17) is a mas-related g-protein receptor x2 (MRGPRX2) modulator. It can be used for the research of inflammation, pain, and autoimmune disorders.
- Research Reagent: For research use only.
- High Purity: 99.03%.
- Versatile Application: Useful for studying inflammation, pain, and autoimmune disorders.
- Multiple Formats: Available as solid or in DMSO solution.
Medchemexpress LLC (E/Z)-Sulindac sulfide | 32004-67-4 | 99.9% | 1 ML
(E/Z)-Sulindac sulfide is a potent γ-secretase modulator (GSM) that selectively reduces Aβ42 production in favor of shorter Aβ species. This product is designed for researching Alzheimer's disease.
- Potent γ-secretase modulator
- Selectively reduces Aβ42 production
- Favors shorter Aβ species
- Suitable for Alzheimer's disease research
Medchemexpress LLC KAT modulator-1 (Compound 3) | 1314006-43-3 | 98.0% | 308.50 | C20H36O2 | 10 MG
KAT modulator-1 is a small-molecule modulator of lysine acetyltransferase (KAT) activity developed for epigenetics research. It has been shown to interact with full-length p300 but not with the isolated catalytic domain, making it a useful probe for studying KAT-protein interactions and regulatory mechanisms in biochemical and cell-based assays. The compound is supplied as a solid with documented storage recommendations and analytical data.
- Modulates lysine acetyltransferase (KAT) activity.
- Interacts with full-length p300 but not the catalytic domain.
- Suitable for biochemical and cell-based epigenetics studies.
- Supplied as a solid with defined storage stability.
- Molecular formula C20H36O2 and molecular weight 308.50.
- High chemical purity typically reported (about 98%).
Medchemexpress LLC 2H-Indol-2-one, 1,3-dihydro-3-hydroxy-3-(2-oxo-2-phenylethyl)-1-(2-phenylethyl)- | 421578-93-0 | 99.8% | C24H21NO3 | 25 MG
GLP-1R modulator C5 is an allosteric modulator enhancing GLP-1 binding to GLP-1R via a transmembrane site (EC50 1.59 ± 0.53 μM).
- Enhances GLP-1 binding to GLP-1R.
- Acts via a transmembrane site.
- High purity of 99.8%.
- White to off-white solid.
- Suitable for research applications.
Medchemexpress LLC Mutant p53 modulator-1 | 2746371-35-5 | 99.9% | C27H32F4N8O2 | 1 ML
Mutant p53 modulator-1 is a compound that acts as a modulator of mutant p53. It has been shown to reduce the progression of cancers that possess a p53 mutation. This compound is identified as 231B in patent WO2021231474A1.
- Molecular weight: 576.59
- Appearance: Solid
- Color: Light yellow to brown
- Shipping: Room temperature in continental US; may vary elsewhere
- Storage: Powder at -20°C for 3 years, 4°C for 2 years. In solvent at -80°C for 6 months, -20°C for 1 month
- Solubility (in vitro): 100 mg/mL (173.43 mM) in DMSO (requires sonication; hygroscopic DMSO significantly impacts solubility, use newly opened DMSO)
TARGETMOL CHEMICALS INC CALCIUM CHANNEL-MODULATO 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Calcium channel-modulator-1 is a calcium channel-modulator (IC500.8 uM) with specialisation to block aortic constriction. purity: 99%
Research Products International Corp 4Meth BDGalact 6 Sulf Sod 50MG
Fluorescent substrate for Morquio A Sulphatase.
- 4-Methylumbelliferone: <100PPM