Sulfoxides
Medchemexpress LLC Mrgprx2 modulator-1 (example 17) | 2781839-42-5 | 99.0% | 459.39 g/mol | C20H19F6N5O | 10 MG
MRGPRX2 modulator-1 (example 17) is a small-molecule modulator of the Mas-related G-protein coupled receptor X2 (MRGPRX2) supplied for preclinical research. It is intended for studies of inflammation, pain signaling, and autoimmune disorders and is characterized by a confirmed molecular formula, molecular weight, and high HPLC purity.
- Small-molecule modulator of MRGPRX2 suitable for preclinical research.
- High purity (99.03% by HPLC) for consistent bioactivity.
- Molecular formula: C20H19F6N5O; molecular weight: 459.39 g/mol.
- Assigned CAS number 2781839-42-5 for unambiguous identification.
- Provided as a powdered research reagent; handle per SDS instructions.
Medchemexpress LLC N-(4-(4-(2-methoxyethoxy)phenyl)thiazol-2-yl)isoxazole-5-carboxamide | 2375779-31-8 | 99.3% | 345.37 g/mol | C16H15N3O4S | 10 MG
GP130 modulator-1 (compound A33) is a small-molecule modulator of the gp130 signaling pathway intended for research use in studies of inflammatory and degenerative disorders.
- Small-molecule gp130 signaling pathway modulator for research use.
- High purity: 99.3%.
- Molecular weight 345.37 g/mol.
- Chemical formula C16H15N3O4S.
- Available in multiple pack sizes, including 10 mg.
- Supplied as a light yellow to yellow solid for laboratory handling and storage.
Medchemexpress LLC Sulforaphane | 4478-93-7 | 99.75% | 177.29 | 200 MG
Sulforaphane is an orally active inducer of the Keap1/Nrf2/ARE pathway. It promotes the transcription of tumor-suppressing proteins and effectively inhibits the activity of HDACs. It protects the heart through the activation of the Keap1/Nrf2/ARE pathway and further induction of HO-1 expression. Sulforaphane suppresses high glucose-induced pancreatic cancer through AMPK-dependent signal transmission and exhibits both anticancer and anti-inflammatory properties.
- Targets: HDAC, Keap1-Nrf2, Apoptosis, Bcl-2 family, Caspase, Reactive oxygen species (ROS)
- Research areas: Inflammation/Immunology, Cancer
Medchemexpress LLC 2H-Indol-2-one, 1,3-dihydro-3-hydroxy-3-(2-oxo-2-phenylethyl)-1-(2-phenylethyl)- | 421578-93-0 | 99.81% | C24H21NO3 | 1 ML
GLP-1R modulator C5 is an allosteric modulator enhancing GLP-1 binding to GLP-1R via a transmembrane site (EC50 1.59 ± 0.53 μM). This compound is for research use only.
- Allosteric modulator
- Enhances GLP-1 binding to GLP-1R
- Via a transmembrane site
Medchemexpress LLC Sulindac sulfide | 49627-27-2 | 98.10% | 250 MG
Sulindac sulfide is a noncompetitive γ-secretase inhibitor, demonstrating an IC50 of 20.2 μM for γ42-secretase activity. This compound is primarily used in research, especially for studying neurological diseases.
- Noncompetitive γ-secretase inhibitor
- IC50 of 20.2 μM for γ42-secretase activity
- Suitable for research applications
- Useful for studying neurological diseases
Medchemexpress LLC Mrgprx4 modulator-1 | 2492596-61-7 | 98.1% | C16H13ClF3NO3 | 10MG
MRGPRX4 modulator-1 is a small-molecule modulator of the Mas-related G-protein coupled receptor X4 used as a research tool for in vitro pharmacology and receptor signaling studies. It is supplied as a solid and as ready-to-use DMSO solutions, and is characterized by defined chemical identity, high purity, and documented storage recommendations.
- Modulates MRGPRX4 receptor activity in vitro.
- Available as solid and DMSO solution formats for flexible use.
- High purity suitable for research applications.
- Documented chemical identity (CAS 2492596-61-7) and formula C16H13ClF3NO3.
- Stable when stored under recommended conditions for extended shelf life.
Medchemexpress LLC Promethazine sulfoxide | 7640-51-9 | MFCD08063694 | 5mg
Promethazine sulfoxide is a metabolite of the histamine H1 receptor antagonist Promethazine (HY-B1296) It is formed from promethazine by the cytochrome P450 (CYP) isoform CYP2D6
Medchemexpress LLC IL-17 modulator 4 | 2446803-65-0 | >99.0% | C27H34N6O2 | 1 ML
IL-17 modulator 4 is a proagent of IL-17 modulator 1, active against IL-17A mediated diseases. This orally active modulator shows promise for the research of conditions including inflammation, autoimmune diseases, infectious diseases, cancer, and precancerous syndrome. It inhibits IL-17A-mediated signaling pathways by stabilizing the IL-17A dimer and preventing its binding to the IL-17RA receptor.
- Modulates IL-17A protein-protein interaction
- Stabilizes IL-17A dimer conformation
- Prevents IL-17A from binding to IL-17RA receptor
- Inhibits IL-17A-mediated signaling pathways
- Exhibits good pharmacokinetic properties in rat models
- Oral bioavailability of 100% in rat models
Medchemexpress LLC GLP-1R modulator C5 | 421578-93-0 | 99.8% | C24H21NO3 | 100 MG
GLP-1R modulator C5 is an allosteric modulator that enhances GLP-1 binding to GLP-1R via a transmembrane site (EC50 1.59 ± 0.53 μM). It is intended for research use only.
- Allosteric modulator
- Enhances GLP-1 binding to GLP-1R
- Suitable for research applications
- Targets glucagon receptor (GCGR)
- Relevant for inflammation or immune system disease research
- Relevant for metabolic or endocrine disease research
- Relevant for digestive system disease research
Medchemexpress LLC GLP-1R modulator C16 | 875005-43-9 | 98.7% | C21H26ClFN2O3 | 10MM/1ML
GLP-1R modulator C16 is an allosteric modulator that enhances GLP-1 binding to GLP-1R via a transmembrane site.
- Enhances GLP-1 binding to GLP-1R
- Operates via a transmembrane site
- Purity of 98.7%
Medchemexpress LLC Sulindac sulfide | 49627-27-2 | MFCD00078044 | 98.1% | 1 ML
Sulindac sulfide is a noncompetitive γ-secretase inhibitor, demonstrating an IC50 of 20.2 μM for γ42-secretase activity. This compound is primarily utilized in neurological disease research, targeting drug metabolites and γ-secretase.
- Noncompetitive γ-secretase inhibitor
- IC50 of 20.2 μM for γ42-secretase activity
- Targeted for drug metabolite research
- Used in neurological disease studies
Medchemexpress LLC Niraparib carboxylic acid metabolite M1 | 1476777-06-6 | 99.7% | 321.37 g/mol | C19H19N3O2 | 10 MG
Niraparib metabolite M1 is the primary carboxylic acid metabolite of the PARP inhibitor niraparib, provided as a solid research reagent for in vitro and analytical use.
- High purity (99.69%) suitable for analytical and research applications.
- Molecular formula C19H19N3O2; molecular weight 321.37 g/mol.
- Solid, light brown to brown appearance.
- Supplied at 10 mg quantity.
- Soluble in DMSO at ≥ 100 mg/mL (in vitro).
- Recommended storage: powder at -20°C (up to 3 years); in solvent at -80°C (up to 2 years).
- Intended for laboratory research use only; not for human therapeutic use.