Sulfoxides
Accela Chembio Inc Diphenyl Sulfoxide | 100g | 945-51-7 | MFCD00002085 | 97+% | Shelf Life: 1260 Days | Light Sensitive
Diphenyl Sulfoxide | 100g | 945-51-7 | MFCD00002085 | 97+% | Shelf Life: 1260 Days | Light Sensitive
Medchemexpress LLC 4-Morpholineethanamine, N-[[4-[(2-chloro-6-fluorophenyl)methoxy]-3-methoxyphenyl]methyl]- | 875005-43-9 | 98.7% | C21H26ClFN2O3 | 25 MG
GLP-1R modulator C16 is an allosteric modulator designed to enhance GLP-1 binding to GLP-1R via a transmembrane site. With an EC50 of 8.43 ± 3.82 μM, this compound is suitable for research applications.
- Enhances GLP-1 binding to GLP-1R
- Allosteric modulator
- High purity: 98.67%
- Soluble in DMSO
- Target: GCGR
- Pathway: GPCR/G Protein
- For research use only
Medchemexpress LLC MRGPRX2 modulator-1 | 2781839-42-5 | 99.0% | 459.39 | 1 ML
MRGPRX2 modulator-1 is a mas-related g-protein receptor x2 (MRGPRX2) modulator. It can be used for the research of inflammation, pain, and autoimmune disorders.
- Modulator of mas-related G-protein receptor X2
- Used for research of inflammation
- Used for research of pain
- Used for research of autoimmune disorders
Medchemexpress LLC YK-2168 | 2571068-74-9 | 98.1% | 315.80 | 5 MG
YK-2168 is a potent and selective CDK9 inhibitor with an IC50 of 5.9 nM. It inhibits phosphorylation of the CDK9 substrate pS2-RNA Pol II C-terminal domain. YK-2168 induces apoptosis in tumor cells, suppresses expression of CDK9-regulated genes such as MYC and Mcl1, and inhibits tumor growth in CDX mice models. It can be used for the research of cancer, such as leukemia.
- Potent and selective CDK9 inhibitor
- Induces apoptosis in tumor cells
- Suppresses expression of CDK9-regulated genes
- Inhibits tumor growth in CDX mice models
- Suitable for research in cancer, such as leukemia
Medchemexpress LLC Kv3.1 modulator 2 | 99.8% | 437.88 | 50 MG
Kv3.1 modulator 2 (compound 4) is a Kv3.1 channels modulator with an EC50 value of 68 nM. This modulator is suitable for laboratory research and studies involving Kv3.1 channels.
- Functions as a Kv3.1 channels modulator
- Has an EC50 value of 68 nM
Medchemexpress LLC MRGPRX2 modulator-1 | 2781839-42-5 | 99.03% | 459.39 | 5 MG
MRGPRX2 modulator-1 (example 17) is a mas-related g-protein receptor x2 (MRGPRX2) modulator. It can be used for the research of inflammation, pain, and autoimmune disorders.
- Research Reagent: For research use only.
- High Purity: 99.03%.
- Versatile Application: Useful for studying inflammation, pain, and autoimmune disorders.
- Multiple Formats: Available as solid or in DMSO solution.
Medchemexpress LLC CXCR7 modulator 2 | 2227426-37-9 | 98.7% | 522.68 | 50 MG
CXCR7 modulator 2 is a C-X-C Chemokine Receptor Type 7 (CXCR7) modulator with a Ki of 13 nM. It is intended for research use only.
- Potent CXCR7-binding affinity (Ki=13 nM)
- Demonstrates β-arrestin activity (EC50=11 nM)
- Improved selectivity in GPCR panel
- Improved therapeutic index in hERG patch-clamp assay
- Moderate to high in vitro turnover in mouse-liver microsomes and hepatocytes
- Good aqueous solubility
- Significantly reduced cardiac fibrosis in isoproterenol-induced cardiac injury model in mice
Medchemexpress LLC Autotaxin modulator 1 | 1548743-69-6 | 99.4% | 10 MG
Autotaxin modulator 1 is an autotaxin (ATX) enzyme inhibitor, extracted from patent WO 2014018881 A1, Compound Example 12b. It is expected to be useful for researching demyelination due to injury or disease, as well as for researching proliferative disorders such as cancer.
- Autotaxin (ATX) enzyme inhibitor
- Useful for researching demyelination due to injury or disease
- Useful for researching proliferative disorders such as cancer
- For research use only
- Appears as a white to off-white solid
- Soluble in DMSO (100 mg/mL)
TARGETMOL CHEMICALS INC METHOTREXATE METABOLITE 50MG
Also available in 10 mg 25 mg 100 mg 200 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Methotrexate metabolite (DAMPA) (DAMPA) is the active metabolite of Methotrexate. Methotrexate is a folic acid antagonist. Methotrexate is used as a chemotherapeutic agent and immunosuppressant. purity: 99%
Medchemexpress LLC D-galactose-6-O-sulfate sodium salt | 125455-62-1 | MFCD00078771 | 95.0% | 282.20 g/mol | C6H11NaO9S | 5 MG
D-Galactose-6-O-sulfate sodium salt is the sodium salt form of D-galactose 6-sulfate supplied as a biochemical reagent for life-science research. It is intended for use as a biological material or organic compound in laboratory assays and analytical applications where a sulfated galactose derivative is required.
- Used as a biochemical reagent for life-science research.
- Sodium salt form for improved aqueous solubility.
- High purity (95.0%).
- Suitable for use as a biological material or organic compound in assays.
- Available in milligram pack sizes for small-scale experiments.
- Identified by CAS 125455-62-1 and formula C6H11NaO9S.
Apexbio Technology LLC Sulforaphane(Synonyms: Broccoli sulforaphane, DL-Sulforaphane, R-Sulforaphane, 1-Isothiocyanato-4-(methylsulfinyl)butane), 25mg, CAS: 4478-93-7.
Sulforaphane (CAS 4478-93-7) is a naturally occurring isothiocyanate abundantly found in vegetables especially broccoli It acts primarily through activation of the Keap1-Nrf2 signaling pathway enhancing cellular defense against oxidative and electrophilic stress Sulforaphane has demonstrated antiproliferative activity in vitro as shown by dose-dependent cell cycle arrest at G2/M and apoptosis induction in HT29 human colon carcinoma cells Such effects involve elevated cyclin A and B1 levels increased pro-apoptotic Bax expression mitochondrial cytochrome c release and poly(ADP-ribose) polymerase cleavage These properties make sulforaphane relevant for investigating cancer chemoprevention and cellular stress responses