Thioureas
Chem-Impex International, Inc. Thiourea | 62-56-6 | MFCD00008067 | 1KG
Thiourea, 62-56-6, MFCD00008067, 1KG
AdipoGen Zoxamide
Chemical. CAS 156052-68-5. Formula C14H16Cl3NO2. MW 336.6. Synthetic. Fungicide. Primarily an oomycete fungicide although it has some activity against ascomycetes and basidiomycetes. The product acts by disruption of the microtubule structure and inhibition of cell division. The mechanism for this activity is through the covalent binding of the active ingredient to beta-tubulin in the cytoskeleton. Scanning microscopy studies showed zoxamide action against blight on potato crops begins after germination, achieving inhibition of hyphal development and sporangia production. This novel mode of action makes zoxamide an important new tool in antiresistance strategies. Can be used as a reference compound.
AdipoGen Budesonide
Chemical. CAS 51333-22-3. Formula C25H34O6. MW 430.5. Budesonide is a glucocorticoid and an agonist of glucocorticoid receptors EC50=45.7pM in a transactivation assay, selective for glucocorticoid over mineralocorticoid receptors. Budesonide is a synthetic anti-inflammatory agent that displays chemopreventive activity. It is used as an anti-inflammatory agent in the treatment of asthma, rhinitis and inflammatory bowel disease and is evaluated in prevention of lung cancer. It prevents formation of lung adenomas and adenocarcinomas in mice following inhalation or oral administration. It also reverses DNA hypomethylation and modulates expression of cancer related genes. Due to its potent activity, as an inhaled glucocorticoid, in reducing airway inflammation, Budesonide has potential as treatment for early COVID-19 infection.
AdipoGen Efavirenz
Chemical. CAS 154598-52-4. Formula C14H9ClF3NO2. MW 315.7. Efavirenz is a non-nucleoside reverse transcriptase inhibitor NNRTI that exhibits antiviral and anticancer activities. Efavirenz binds to wild-type and mutant HIV-1 RTs Ki= 2.93nM and 3.85-56.5nM, respectively. It inhibits wild-type and mutant HIV-1 viral replication in MT-4 human T lymphoid cells IC95s = 1.5-1,500 nM. Efavirenz also prevents RNA plus-strand initiation with an IC50 value of 17nM. Efavirenz is an anti-HIV drug, commonly used in combination therapy for AIDS treatment. It is part of highly active antiretroviral therapy HAART for the treatment of a human immunodeficiency virus HIV type 1. In various cancer cell lines, Efavirenz inhibits cellular proliferation and increases activation of p53. CARD8 inflammasome senses HIV-1 protease activity. In HIV1-infected cells, CARD8 cannot detect the virus because the viral protease remains inactive as a subunit of unprocessed Gag-Pol polyprotein.
AdipoGen PP2
Chemical. CAS 172889-27-9. Formula C15H16ClN5. MW 301.8. Highly potent and selective Scr family tyrosine kinase inhibitor. Reduces cancer metastasis. Apoptotic. Antitumor compound. RIP2 inhbitor. Blocks TGF-beta-mediated cellular responses. Autophagy modulator.
AdipoGen Efavirenz
Chemical. CAS 154598-52-4. Formula C14H9ClF3NO2. MW 315.7. Efavirenz is a non-nucleoside reverse transcriptase inhibitor NNRTI that exhibits antiviral and anticancer activities. Efavirenz binds to wild-type and mutant HIV-1 RTs Ki= 2.93nM and 3.85-56.5nM, respectively. It inhibits wild-type and mutant HIV-1 viral replication in MT-4 human T lymphoid cells IC95s = 1.5-1,500 nM. Efavirenz also prevents RNA plus-strand initiation with an IC50 value of 17nM. Efavirenz is an anti-HIV drug, commonly used in combination therapy for AIDS treatment. It is part of highly active antiretroviral therapy HAART for the treatment of a human immunodeficiency virus HIV type 1. In various cancer cell lines, Efavirenz inhibits cellular proliferation and increases activation of p53. CARD8 inflammasome senses HIV-1 protease activity. In HIV1-infected cells, CARD8 cannot detect the virus because the viral protease remains inactive as a subunit of unprocessed Gag-Pol polyprotein.
AdipoGen MnTBAP chloride
Chemical. CAS 55266-18-7. Formula C48H28MnN4O8Cl. MW 879.2. Cell permeable superoxide dismutase SOD mimetic. Potent inhibitor of peroxynitrite-induced oxidative reactions peroxynitrite scavenger, but not a scavenger of nitric oxide NO. Neuronal apoptosis inhibitor. Protects T cells from superoxide generation, caspase-dependent DNA loss and cell death. Lipopolysaccharide-induced TNF-alpha production inhibitor, by prevention of intracellular ROS generation and subsequent inactivation of p38 MAPK and SAPK/JNK. .
AdipoGen KBU2046
Chemical. CAS 1143863-69-7. Formula C15H11FO2. MW 242.2. Highly selective metastasis inhibitor in vitro. Binds to and stabilizes Cdc37-HSP90beta heterocomplexes, consequently blocking its function and inhibiting cancer cell motility. Does not bind to Cdc37 or HSP90beta alone. Inhibits cancer metastasis in vivo in murine models of human prostate and breast cancer. Shown to exhibit a complete lack of cellular cytotoxicity and systemic toxicity.
AdipoGen KBU2046
Chemical. CAS 1143863-69-7. Formula C15H11FO2. MW 242.2. Highly selective metastasis inhibitor in vitro. Binds to and stabilizes Cdc37-HSP90beta heterocomplexes, consequently blocking its function and inhibiting cancer cell motility. Does not bind to Cdc37 or HSP90beta alone. Inhibits cancer metastasis in vivo in murine models of human prostate and breast cancer. Shown to exhibit a complete lack of cellular cytotoxicity and systemic toxicity.
AdipoGen CTPB
Chemical. CAS 586976-24-1. Formula C31H43ClF3NO2. MW 554.1. Potent activator of p300 HAT histone acetyltransferase activity, which has an important role in regulation of gene expression. Does not show PCAF p300/CBP-associated factor HAT activities. Membrane-impermeable that requires a carrier to pass the membrane barrier of cells.
AdipoGen Suc-Leu-Leu-Val-Tyr-AMC
Chemical. CAS 94367-21-2. Formula C40H53N5O10. MW 763.9. Fluorogenic substrate for measuring the chymotrypsin-like peptidase activity of the 20S proteasome, calpains and other chymotrypsin-like proteases. Extinction 380nm. Emission 460 nm. This substrate is useful for inhibitor screening and kinetic analysis.
AdipoGen 1-Azakenpaullone
Chemical. CAS 676596-65-9. Formula C15H10BrN3O. MW 328.2. Potent and ATP-competitive GSK-3beta glycogen synthase kinase-3beta inhibitor IC50 = 18 nM.
AdipoGen Z-Leu-Leu-Leu-AMC
Chemical. CAS 152015-61-7. Formula C36H48N4O7. MW 648.8. Fluorogenic substrate for measuring the chymotrypsin-like peptidase activity of the 20S proteasome. Excitation 345nm. Emission 445nm. This substrate is useful for inhibitor screening and kinetic analysis.
AdipoGen Raptinal
Chemical. CAS 1176-09-6. Formula C28H18O2. MW 386.4. Rapid apoptosis inducer that initiates intrinsic pathway caspase-dependent apoptosis within minutes in multiple cell lines and in vivo systems. Exerts anticancer activity in vivo, likely through the induction of apoptosis. Induces cell death against various cancer and non-cancerous cell lines with 24 hour IC50 values between 0.7-3.4µM indicating activity across a wide range of cell lines. Activates the intrinsic pathway and requires functional mitochondria for apoptosis induction. Treated cells did not undergo mitochondrial-permeability-transition-pore MPTP formation, suggesting a mitochondrial outer membrane permeabilization MOMP model of cytochrome c release.
AdipoGen YC-1
Chemical. CAS 170632-47-0. Formula C19H16N2O2. MW 304.4. Nitric oxide NO independent, superoxide-sensitive soluble guanylyl cyclase sGC activator. Induces concentration-dependent increase in cGMP levels. Inhibits platelet adhesion to collagen. Thombosis inhibitor. Non-specific phosphodiesterase inhibitor. Na channel blocker. Anticancer compound. HIF-alpha inhibitor. Blocks angiogenesis. Tumor growth inhibitor. Apoptosis inducer. NK cell differentiation enhancer. TRAIL sensitizer.