Anthracyclines
Sigma Aldrich Fine Chemicals Biosciences Doxorubicin hydrochloride50MG
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.for further information and support please go to the website of the issuing Pharmacopoeia.
Selleck Chemical LLC Daunorubicin HCl S3035-1g
Daunorubicin HCl inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0 02 M in a cell-free assay Daunorubicin is a topoisomerase II inhibitor that induces apoptosis Daunorubicin (RP 13057) HCl can be used to induce animal models of Kidney Disease
Medchemexpress LLC Doxorubicin (hydrochloride) | 25316-40-9 | MFCD00077757 | C27H30ClNO11 | 2 G
Doxorubicin hydrochloride is a cytotoxic anthracycline antibiotic and a potent anti-cancer chemotherapy agent. It functions as a human DNA topoisomerase I and II inhibitor, reducing basal phosphorylation of AMPK and inducing apoptosis and autophagy. This orange-red crystalline solid is isolated from cultures of Streptomyces peucetius var. caesius.
- Potent human DNA topoisomerase I and II inhibitor
- Reduces basal phosphorylation of AMPK
- Induces apoptosis and autophagy
- Functions as a DNA intercalator
- Acts as a fluorescent dye
- Exhibits antitumor and antibiotic activity
- Inhibits reverse transcriptase and RNA polymerase
Medchemexpress LLC Doxorubicin (hydrochloride) | 25316-40-9 | C27H30ClNO11 | 25 MG
Doxorubicin hydrochloride (Hydroxydaunorubicin hydrochloride; ADR) is a cytotoxic anthracycline antibiotic and an anti-cancer chemotherapy agent. It functions as a potent human DNA topoisomerase I and topoisomerase II inhibitor, reducing basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Additionally, it induces apoptosis and autophagy.
- Cytotoxic anthracycline antibiotic
- Anti-cancer chemotherapy agent
- Potent human DNA topoisomerase I and II inhibitor
- Reduces basal phosphorylation of AMPK and acetyl-CoA carboxylase
- Induces apoptosis and autophagy
- Suitable for neutral or weakly acidic solvents
- Melting/freezing point of 216°C
- For research use only
Medchemexpress LLC Doxorubicin (hydrochloride) | 25316-40-9 | C27H30ClNO11 | 10 G
Doxorubicin (hydrochloride) | 25316-40-9 | C27H30ClNO11 | 10 G
Medchemexpress LLC Daunorubicin (hydrochloride) | 23541-50-6 | 99.7% | 25 MG
Daunorubicin hydrochloride is a potent topoisomerase II inhibitor with significant anti-tumor activity. This anthracycline antibiotic inhibits both DNA and RNA synthesis, functioning as a cytotoxin that reduces cancer cell viability and induces apoptosis and necrosis. It is utilized in research for various infections and cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, and Wilms' tumor. The compound is a pink to red solid, stable under recommended storage conditions, with a melting point of 190°C.
- Target: topoisomerase, DNA/RNA synthesis, ADC payload, bacterial, autophagy, apoptosis, antibiotic
- Research areas: infection, neurological disease, cancer
- CAS number: 23541-50-6
- Molecular formula: C27H30ClNO10
- Molecular weight: 563.98
- Appearance: pink to red solid
- Purity (LCMS): 99.7%
- Melting point: 190°C
Apexbio Technology LLC Doxorubicin 23214-92-8 10mM (in 1mL DMSO)
Doxorubicin is an anthracycline antibiotic commonly used as an anti-cancer agent targeting DNA replication machinery Its mechanism of action involves intercalation into DNA double helices and subsequent inhibition of DNA topoisomerase II impeding DNA synthesis and causing genomic instability Additionally Doxorubicin mediates chromatin remodeling by facilitating histone displacement from active chromatin contributing further to DNA damage and transcriptional dysregulation It is extensively employed in studies involving hematologic malignancies solid tumors and sarcomas frequently serving as a chemotherapeutic reference compound In biochemical assays Doxorubicin has demonstrated inhibitory effects on Topoisomerase II with an IC50 typically ranging between 1-10 M depending on assay conditions and cell lines applied
Selleck Chemical LLC Daunorubicin HCl S3035-50mg
Daunorubicin HCl inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0 02 M in a cell-free assay Daunorubicin is a topoisomerase II inhibitor that induces apoptosis Daunorubicin (RP 13057) HCl can be used to induce animal models of Kidney Disease
Medchemexpress LLC BIIE-0246 hydrochloride | 246146-55-4 | MFCD04113026 | >98.0% | 896.05 g/mol | C49H57N11O6 | 50 MG
BIIE-0246 is a selective, non-peptide antagonist of the neuropeptide Y Y2 receptor used as a research tool in receptor pharmacology and preclinical studies. It is typically supplied as the hydrochloride salt and is appropriate for in vitro assays and parenteral in vivo investigations.
- Selective antagonist of the NPY Y2 receptor.
- Potent activity (IC50 ≈ 15 nM).
- Typically supplied as a hydrochloride salt for lab use.
- Purity ≥98.0% by HPLC.
- Molecular weight 896.05 g/mol.
- Available in mg-scale quantities for research applications.
- Intended for research use only; not for human therapeutic use.
AdipoGen Doxorubicin hydrochloride
Chemical. CAS 25316-40-9. Formula C27H29NO11 . HCl. MW 579.98. Doxorubicin, a broad spectrum anthracycline antibiotic, inhibits DNA and RNA synthesis in mammalian cells and has been shown to be a very effective anti-tumor agent. Doxorubicin binds to nucleic acids by intercalating the DNA double helix and stabilizing topoisomerase II cleavage complexes, leading to DNA strand breaks at specific doxorubicin-induced sites and formation of reactive oxygen species ROS in cells. It also been shown to evict histones leading to chromatin damage. Doxorubicin induces apoptosis by inducing the accumulation of the p53 tumor suppressor protein and has been shown to have immunosuppressive properties. DOX can reduce mitochondrial NADH accumulation and impair oxidative phosphorylation in heart tissues, events associated with reduced glucose uptake.
Sigma Aldrich Fine Chemicals Biosciences Naltrindole hydrochloride50MG
Naltrindole hydrochloride50MG
Medchemexpress LLC Doxorubicin hydrochloride | 25316-40-9 | C₂₇H₃₀ClNO₁₁ | 5 MG
Doxorubicin hydrochloride is a cytotoxic anthracycline antibiotic and an anti-cancer chemotherapy agent. It is a potent human DNA topoisomerase I and topoisomerase II inhibitor, reducing basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. It also induces apoptosis and autophagy.
- Potent human DNA topoisomerase I and topoisomerase II inhibitor
- Reduces basal phosphorylation of AMPK
- Induces apoptosis and autophagy
- Used in infection and cancer research
Sigma Aldrich Fine Chemicals Biosciences Doxorubicin hydrochloride | 25316-40-9 | MFCD00077757 | 1 mg
Doxorubicin hydrochloride | Purity: 98.0-102.0% | Mol Wt: 579.98 | 25316-40-9 | MFCD00077757 | 1 mg
Medchemexpress LLC Doxorubicin hydrochloride | 25316-40-9 | MFCD00077757 | 99.3% | 579.98 g/mol | C27H30ClNO11 | 10 MG
Doxorubicin hydrochloride is an anthracycline antibiotic with cytotoxic activity supplied as a high-purity analytical standard for laboratory research. It functions as a DNA intercalator and inhibits topoisomerases I and II, making it useful as a biochemical reagent and reference in cell-based assays and analytical method development.
- High purity (99.33%) suitable for analytical applications.
- Confirmed identity: CAS 25316-40-9, molecular weight 579.98 g/mol.
- Available in multiple package sizes, including 10 mg.
- Acts as a DNA intercalator and topoisomerase I/II inhibitor.
- Suitable for biochemical assays, cell-based studies, and analytical standards.