Anthracyclines
Medchemexpress LLC BIIE-0246 hydrochloride | 246146-55-4 | MFCD04113026 | >98.0% | 896.0 g/mol | C49H57N11O6 | 5 MG
BIIE-0246 hydrochloride is a selective, non-peptide antagonist of the neuropeptide Y Y2 receptor supplied as the hydrochloride salt for research use. It is used in pharmacological studies to probe NPY-mediated signaling and is provided at high purity for in vitro and in vivo experiments.
- Selective NPY Y2 receptor antagonist
- High purity (>98.0%) suitable for research
- Hydrochloride salt for improved aqueous solubility
- Molecular formula C49H57N11O6; molar mass 896.0 g/mol
- Available in small research pack sizes, for example 5 MG
Medchemexpress LLC BIIE-0246 | 246146-55-4 | 99.1% | 896.05 g·mol⁻¹ | C49H57N11O6 | 1 ML
BIIE-0246 is a potent, selective non-peptide antagonist of the neuropeptide Y Y2 receptor (NPY2R) used in preclinical neuroscience research. It has an IC50 of approximately 15 nM (rat [125I]PYY3-36) and modulates downstream signaling pathways including p-AKT and p44/42 MAPK. The compound is supplied as a 10 mM solution in DMSO with reported high purity for research use only.
- Potent NPY Y2 receptor antagonist (IC50 ~15 nM).
- Ready-to-use 10 mM solution in DMSO for in vitro assays.
- High reported purity (99.1%).
- Molecular weight 896.05 g·mol⁻¹ and formula C49H57N11O6.
- Suitable for studies of NPY2R signaling and related pathways.
Medchemexpress LLC Daunorubicin hydrochloride | 23541-50-6 | MFCD04974507 | 99.7% | 563.98 g/mol | C27H30ClNO10 | 5 MG
Daunorubicin hydrochloride is an anthracycline antibiotic and potent cytotoxic research compound that intercalates DNA and inhibits topoisomerase II. Provided as the hydrochloride salt for research use, it is commonly used in oncology and biochemical studies where controlled, small-quantity reagent handling and high-purity material are required.
- Anthracycline antibiotic with cytotoxic activity.
- Potent topoisomerase II inhibitor causing DNA intercalation.
- Hydrochloride salt form for enhanced solubility and handling.
- High purity suitable for analytical and biological assays.
- Molecular weight 563.98 g/mol; formula C27H30ClNO10.
- Supplied in small measured quantities for research workflows.
Medchemexpress LLC BIIE-0246 hydrochloride | 99.1% | 896.05 g/mol | C49H57N11O6
BIIE-0246 hydrochloride is a potent, selective, non-peptide antagonist of the neuropeptide Y Y2 receptor (NPY2R) used in pharmacological and neuroscience research. Supplied as a white to off-white solid, the compound is offered as bulk material and as pre-made DMSO solutions for in vitro studies. Documentation such as COA, SDS, and analytical reports are available to support experimental reproducibility.
- Potent and selective NPY Y2 receptor antagonist for research applications.
- High purity (reported at 99.1%), reducing variability in assays.
- Available as solid material and as pre-made DMSO solutions for convenience.
- White to off-white solid appearance suitable for laboratory handling.
- Stability data provided for powder and solutions to aid storage planning.
- Analytical documentation (COA, HNMR, HPLC) available to verify quality.
Apexbio Technology LLC Doxorubicin (Adriamycin) HCl 25316-40-9 10mg
Doxorubicin hydrochloride an anthracycline antibiotic derivative exhibits cytotoxic activity and is widely utilized as an anticancer chemotherapeutic agent Its mechanism involves intercalating into DNA double-strands inhibiting DNA topoisomerase II activity and consequently interrupting replication processes causing DNA damage and altered chromatin structure by histone displacement In biomedical research settings doxorubicin hydrochloride is employed in vitro and in animal models to study therapeutic strategies against hematologic malignancies solid tumors and sarcomas Reported IC50 values vary with cell type and assay conditions typically ranging between approximately 0 1 M to 2 M in various tumor-derived cell models
Apexbio Technology LLC Doxorubicin 23214-92-8 10mM (in 1mL DMSO)
Doxorubicin is an anthracycline antibiotic commonly used as an anti-cancer agent targeting DNA replication machinery Its mechanism of action involves intercalation into DNA double helices and subsequent inhibition of DNA topoisomerase II impeding DNA synthesis and causing genomic instability Additionally Doxorubicin mediates chromatin remodeling by facilitating histone displacement from active chromatin contributing further to DNA damage and transcriptional dysregulation It is extensively employed in studies involving hematologic malignancies solid tumors and sarcomas frequently serving as a chemotherapeutic reference compound In biochemical assays Doxorubicin has demonstrated inhibitory effects on Topoisomerase II with an IC50 typically ranging between 1-10 M depending on assay conditions and cell lines applied
Apexbio Technology LLC Doxorubicin 23214-92-8 25mg
Doxorubicin is an anthracycline antibiotic commonly used as an anti-cancer agent targeting DNA replication machinery Its mechanism of action involves intercalation into DNA double helices and subsequent inhibition of DNA topoisomerase II impeding DNA synthesis and causing genomic instability Additionally Doxorubicin mediates chromatin remodeling by facilitating histone displacement from active chromatin contributing further to DNA damage and transcriptional dysregulation It is extensively employed in studies involving hematologic malignancies solid tumors and sarcomas frequently serving as a chemotherapeutic reference compound In biochemical assays Doxorubicin has demonstrated inhibitory effects on Topoisomerase II with an IC50 typically ranging between 1-10 M depending on assay conditions and cell lines applied
Apexbio Technology LLC Daunorubicin 20830-81-3 10mg
Daunorubicin (20830-81-3) is a small-molecule inhibitor targeting DNA topoisomerase II It is designed to inhibit this target thereby disrupting nucleic acid synthesis within tumor cells Daunorubicin exerts its biological activity primarily through stabilizing the topoisomerase II-DNA cleavage complex interfering with DNA replication and transcription In in vitro studies daunorubicin demonstrates inhibition of metabolic incorporation of nucleoside precursors into DNA and RNA with reported IC50 values for inhibition of leukemia cell growth ranging from 0 02 1 M depending on cellular context and assay conditions Based on these pharmacological properties daunorubicin holds research potential in oncology studies related to chemotherapy-induced genotoxicity and nucleic acid metabolism
Sigma Aldrich Fine Chemicals Biosciences Doxorubicin hydrochloride | 25316-40-9 | MFCD00077757 | 1 mg
Doxorubicin hydrochloride | Purity: 98.0-102.0% | Mol Wt: 579.98 | 25316-40-9 | MFCD00077757 | 1 mg
AdipoGen Doxorubicin hydrochloride
Chemical. CAS 25316-40-9. Formula C27H29NO11 . HCl. MW 579.98. Doxorubicin, a broad spectrum anthracycline antibiotic, inhibits DNA and RNA synthesis in mammalian cells and has been shown to be a very effective anti-tumor agent. Doxorubicin binds to nucleic acids by intercalating the DNA double helix and stabilizing topoisomerase II cleavage complexes, leading to DNA strand breaks at specific doxorubicin-induced sites and formation of reactive oxygen species ROS in cells. It also been shown to evict histones leading to chromatin damage. Doxorubicin induces apoptosis by inducing the accumulation of the p53 tumor suppressor protein and has been shown to have immunosuppressive properties. DOX can reduce mitochondrial NADH accumulation and impair oxidative phosphorylation in heart tissues, events associated with reduced glucose uptake.
TARGETMOL CHEMICALS INC DAUNORUBICIN HYDROCHLORI 50MG
Also available in 5 mg 10 mg 25 mg 100 mg 200 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Daunorubicin hydrochloride (Rubidomycin hydrochloride) an anthracycline aminoglycoside antineoplastic inhibits DNA replication and repair and RNA and protein synthesis. purity: 99%
Sigma Aldrich Fine Chemicals Biosciences R -SCH-23390 hydrochloride5MG
hydrochloride R -SCH-23390 hydrochloride5MG
Sigma Aldrich Fine Chemicals Biosciences Doxorubicin hydrochloride10MG
Chemical structure tetracycline
Sigma Aldrich Fine Chemicals Biosciences Doxorubicin hydrochloride50MG
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.for further information and support please go to the website of the issuing Pharmacopoeia.