Cinnamic acids and derivatives
Apexbio Technology LLC Entacapone 130929-57-6 10mg
Entacapone (CAS 130929-57-6) is a selective second-generation inhibitor of catechol-O-methyltransferase (COMT) It demonstrates potent inhibition of total COMT in mouse liver with reported IC50 and Ki values of 20 1 nM and 10 7 nM respectively In rat models IC50 values for soluble COMT and membrane-bound COMT are 14 3 nM and 73 3 nM Entacapone is primarily utilized in research as an adjunct to levodopa and dopa decarboxylase inhibitor regimens in Parkinson s disease studies given its ability to suppress the formation of 3-O-methyldopa thereby enhancing levodopa bioavailability and prolonging its pharmacological effect
Medchemexpress LLC Tyrphostin AG30 | 122520-79-0 | MFCD09739079 | 99.7% | 205.17 | C10H7NO4 | 1 ML
Tyrphostin AG30 (CAS 122520-79-0) is a small-molecule inhibitor of EGFR tyrosine kinase supplied as a 10 mM solution in DMSO (1 mL), intended for biochemical and cell-based research.
- Potent and selective EGFR tyrosine kinase inhibition.
- Supplied as a ready-to-use 10 mM solution in DMSO.
- High purity suitable for research applications.
- Molecular weight 205.17 and formula C10H7NO4 provided for characterization.
- Storage recommendations provided to maintain compound stability.
Medchemexpress LLC M-coumaric acid (standard) | 588-30-7 | 99.9% | 164.16 | 10 MG
M-coumaric acid (standard) | 588-30-7 | 99.9% | 164.16 | 10 MG
Medchemexpress LLC Tyrphostin A1 | 2826-26-8 | 99.0% | 184.19 | 10 MG
Tyrphostin A1 (AG9) inhibits CD40L-stimulated IL-12 production in macrophage cultures and antigen-induced generation of Th1 cells. It is for research use only.
- Inhibits CD40L-stimulated IL-12 production in macrophage cultures
- Decreases IL-12 p40 production in a dose-dependent manner
- Blocks CD40L-induced translocation of NF-κB to the nucleus
- Reduces activation of IL-12 p40 gene
- Leads to a decrease in the generation of myelin basic protein (MBP) specific encephalitogenic T cells in vivo therapy
- Attenuates experimental allergic encephalomyelitis (EAE) in SJL/J mice
- Weaker inhibitor of TK compared to other tyrphostins, useful for differentiating TK-mediated effects
Apexbio Technology LLC (E,E)-Bisdemethoxycurcumin 33171-05-0 10mg
(E E)-Bisdemethoxycurcumin (CAS 33171-05-0) is a naturally derived curcuminoid and a structural analog within the demethoxycurcumin class Research demonstrates that this compound modulates multiple inflammatory signaling pathways and alters the expression of various inflammatory mediators It has been shown to induce cell cycle arrest promote apoptosis in cancer cells and inhibit proliferation-related pathways (E E)-Bisdemethoxycurcumin is widely utilized in studies investigating the molecular mechanisms of inflammation tumor cell biology and the pharmacological properties of curcuminoid derivatives
Medchemexpress LLC m-Coumaric acid (Standard) | 588-30-7 | 99.9% | 164.16 | 100 MG
m-Coumaric acid (Standard) | 588-30-7 | 99.9% | 164.16 | 100 MG
eMolecules 2699937-04-5 | Medchem Express | MRL-494 (hydrochloride) | 5mg | 552386588 | HY-128773A | 659.13 | C26H36ClFN16O2
Medchem Express | Apramycin (sulfate) | 100mg | 446273816 | HY-B1329 | 65710-07-8 | 637.660 | C21H43N5O15S
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Sigma Aldrich Fine Chemicals Biosciences 4-Formylcinnamic acid, predominantly trans | 23359-08-2 | MFCD00006955 | 5G
4-Formylcinnamic acid, predominantly trans | Mol Wt: 176.17 | 23359-08-2 | MFCD00006955 | 5G
Medchemexpress LLC 2-acetamido-3-phenylprop-2-enoic acid | 5469-45-4 | MFCD00188416 | 99.5% | 205.21 g·mol⁻¹ | C11H11NO3 | 25 G
α-Acetamidocinnamic acid is an alkaloid-derived research reagent (CAS 5469-45-4) used in biochemical and natural product studies. It is supplied as a high-purity solid for use as a reference compound, synthetic building block, or analytical standard. Certificate of analysis and safety data sheet are available.
- CAS number 5469-45-4.
- Molecular formula C11H11NO3.
- Molecular weight 205.21 g·mol⁻¹.
- Purity 99.5%.
- Supplied as a solid.
- Available pack sizes: 25 g, 50 g, 100 g.
- Certificate of analysis and safety data sheet available.
Medchemexpress LLC 4-methylcinnamic acid | 1866-39-3 | MFCD00002697 | 99.6% | 162.19 | C10H10O2 | 1 ML
4-methylcinnamic acid is a cinnamic acid derivative used in research with reported antifungal activity. It is supplied for in vitro and in vivo studies and is provided as powder or concentrated stock solutions with guidance for formulation and storage.
- Cas number 1866-39-3.
- Molecular formula C10H10O2.
- Molecular weight 162.19 g/mol.
- Purity approximately 99.6%.
- Available as powder and in-solvent preparations.
- Solvent guidance: DMSO for high-concentration stocks.
- Stock preparation guidance for 1, 5, and 10 mM solutions from mg quantities.
- Storage recommendations: powder and in-solution temperature ranges with multi-year stability.
Medchemexpress LLC p-Coumaric acid-13C3 | 1261170-80-2 | 167.14 | 500 UG
p-Coumaric acid-13C3 is the 13C-labeled p-Coumaric acid, an abundant isomer of cinnamic acid known for its antitumor and anti-mutagenic activities.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Purity of 99.12%.
- Appears as a solid, white to off-white.