Flavonoids
Medchemexpress LLC (-)-epicatechin (standard) | 490-46-0 | 290.27 g/mol | C15H14O6 | 10 MG
(-)-Epicatechin (standard) is an analytical reference material of the flavonoid (-)-epicatechin provided as a 10 mg quantity for research and analytical use. It is intended for assay calibration, method development, and reference measurements; not for human or clinical use. Recommended storage is 4°C sealed and protected from light and moisture; in solvent, store at -80°C for up to 6 months or -20°C for up to 1 month.
- Analytical reference standard of (-)-epicatechin.
- Intended for research and analytical applications; not for human use.
- CAS number 490-46-0; molecular formula C15H14O6.
- Supplied as a 10 mg quantity suitable for calibration and method development.
- Recommended storage: 4°C sealed; in solvent store at -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC 5,7-Dimethoxyflavone | 21392-57-4 | 100 MG
5,7-Dimethoxyflavone is a natural compound found in *Kaempferia parviflora* that exhibits diverse biological activities. It possesses anti-obesity, anti-inflammatory, and antineoplastic effects. This compound is known to inhibit cytochrome P450 (CYP) 3As and acts as a potent Breast Cancer Resistance Protein (BCRP) inhibitor.
- Inhibits cytochrome P450 (CYP) 3As
- Potent Breast Cancer Resistance Protein (BCRP) inhibitor
- Exhibits anti-obesity effects
- Demonstrates anti-inflammatory properties
- Shows antineoplastic activity
- Reduces liver CYP3A11 and CYP3A25 protein expression in mice
- Inhibits sarcopenia in aged mice
- Decreases body weight gain and inhibits fatty liver in HFD mice
Medchemexpress LLC Acacetin (5,7-dihydroxy-4'-methoxyflavone) | 480-44-4 | MFCD00016936 | 99.7% | 284.26 | C16H12O5 | 10 MG
Acacetin (5,7-dihydroxy-4'-methoxyflavone) is an O-methylated flavone used as a research reagent for studies of apoptosis, autophagy, and inflammatory signaling. It is supplied as a high-purity reference material for in vitro and preclinical experiments.
- CAS number: 480-44-4.
- Molecular formula: C16H12O5.
- Molecular weight: 284.26 g/mol.
- Purity: 99.7%.
- Available pack sizes: 1 mg-1 g for laboratory use.
- Documentation provided: data sheet, certificate of analysis, and safety data sheet.
Medchemexpress LLC Luteolin-3',7-diglucoside | 52187-80-1 | 5 MG
Luteolin-3′,7-diglucoside is a glycoside that can be isolated from *R. luteolin*. It significantly inhibits cataracts induced in ovine lenses and also inhibits the activity of *Ureaplasma urealyticum* ATCC and clinical strains.
- Glycoside isolated from *R. luteolin*.
- Significantly inhibits cataracts induced in ovine lenses.
- Inhibits activity of *Ureaplasma urealyticum* ATCC and clinical strains.
- High purity of 97.0%.
- Appears as a solid, light yellow to yellow.
Medchemexpress LLC 5,7,3',4'-Tetramethoxyflavone | 855-97-0 | 10 MG
5,7,3',4'-Tetramethoxyflavone is an orally active polymethoxyflavone (PMF) isolated from M. exotica. It possesses various bioactivities, including anti-fungal, anti-malarial, anti-mycobacterial, and anti-inflammatory activities. It also exhibits chondroprotective activity by targeting β-catenin signaling.
- Possesses anti-fungal, anti-malarial, anti-mycobacterial, and anti-inflammatory properties.
- Exhibits chondroprotective activity by targeting β-catenin signaling.
- Protects chondrocytes from ER stress-induced apoptosis.
- Decreases inflammatory cytokines.
- Inhibits chondrocyte hypertrophy.
Medchemexpress LLC Myricetin 3'-glucoside | 520-14-9 | 5 MG
Myricetin 3'-glucoside is a glycoside derivative of quercetin. It significantly prevents ethanol-induced hepatotoxicity by reducing hepatic transaminase activity and inflammatory response in HepG2 cells, indicating a protective effect on alcohol-induced liver injury. It has a molecular weight of 480.38 and a chemical formula of C21H20O13.
- Purity: 99.98%
- Appearance: solid, off-white to light yellow
- Molecular weight: 480.38
- Formula: C21H20O13
- Smiles: O=C1C(C(OC(C(C=C2O)=CC(O[C@@H]([C@@H]([C@H]3O)O)O[C@@H]([C@H]3O)CO)=C2O)=C1O)=CC(O)=C4)=C4O
- Structure classification: flavonoids, flavonols
- Initial source: plants, Myrtaceae, Syzygium malaccense (L.) Merr. et Perry
- Solubility (in vitro): DMSO: 50 mg/mL (104.08 mM; needs ultrasonic; hygroscopic DMSO has a significant impact on solubility, use newly opened DMSO)
Medchemexpress LLC Myricetin 3-O-glucoside | 19833-12-6 | 5 MG
Myricetin 3-O-glucoside is a flavonol found in *Tibouchina paratropica* and Hakmeitau beans. This compound demonstrates a range of biological activities, including anti-Leishmanial, anti-inflammatory, and antimicrobial properties.
- Demonstrates anti-Leishmanial activity
- Demonstrates anti-inflammatory activity
- Demonstrates antimicrobial activity
- Exhibits anti-inflammatory effects in mouse RAW264.7 cells
Medchemexpress LLC 4'-Hydroxyflavanone | 6515-37-3 | 1 ML
4'-Hydroxyflavanone is an inhibitor of SREBP maturation and lipid synthesis, and a synthetic analogue of flavanone. It is used in research into hepatic steatosis and dyslipidemia.
- Purity of 99.75%
- Molecular weight of 240.25 g/mol
- Chemical formula C15H12O3
- Classified as a flavonoid, flavanone, phenol, and monophenol
- Isolated from Aspergillus niger
- Provided as a 10 mM solution in DMSO
- Store powder at -20°C for 3 years, or 4°C for 2 years
- Store solution at -80°C for 6 months, or -20°C for 1 month
Medchemexpress LLC 7-Hydroxyflavone | 6665-86-7 | 100 MG
7-Hydroxyflavone is a flavonoid isolated from *Clerodendrum phlomidis*, demonstrating anti-inflammatory activity. It protects renal cells from nicotine (NIC)-associated cytotoxicity through the ERK/Nrf2/HO-1 pathway, and inhibits PKM2, COX-2, and 5-LOX. This compound is orally active.
- Isolated from *Clerodendrum phlomidis*
- Protects renal cells from nicotine-associated cytotoxicity
- Inhibits PKM2 with an IC50 of 2.12 μM
- Inhibits COX-2 and 5-LOX with IC50s of 27 μg/mL and 33 μg/mL
- Orally active
- Ameliorates neuropathic pain in mice models
- Improves high-fat diet-induced non-alcoholic fatty liver disease
- Reduces malondialdehyde (MDA) and ROS levels in HepG2 cells
Medchemexpress LLC Myricetin 3-O-glucoside (Myricetin 3-β-D-glucopyranoside) | 19833-12-6 | 1 MG
Myricetin 3-O-glucoside is a flavonol found in *Tibouchina paratropica* and Hakmeitau beans. It demonstrates anti-Leishmanial, anti-inflammatory, and antimicrobial activities. This product is for research use only.
- Demonstrates anti-Leishmanial activity
- Demonstrates anti-inflammatory activity
- Demonstrates antimicrobial activity
- Found in *Tibouchina paratropica* and Hakmeitau beans
Medchemexpress LLC Luteolin-7-rutinoside | 20633-84-5 | 5 MG
Luteolin-7-rutinoside possesses both anti-arthritic and antifungal activities, which can lead to a combination therapy for treating fungal arthritis caused by *C. albicans* infection. It is intended for research use only and not for sale to patients.
- Possesses anti-arthritic activity.
- Possesses antifungal activity.
- Reduces proliferation of T cells in a dose-dependent manner.
- Shifts Th1-Th2 balance away from Th1 towards Th2-type responses.
- Inhibits nitric oxide (NO) production from macrophages.
Apexbio Technology LLC (±)-AMG 487 50mg
racemic Baclofen -AMG 487 is a small-molecule antagonist targeting the chemokine receptor CXCR3 It is designed to inhibit ligand-induced CXCR3-mediated immune cell migration thereby modulating lymphocyte recruitment to inflammatory and metastatic sites racemic Baclofen -AMG 487 exerts its biological activity primarily through selective inhibition of CXCR3-mediated cell migration In in vitro studies racemic Baclofen -AMG 487 demonstrates inhibition of ligand-induced CXCR3-dependent cell movement Based on these pharmacological properties racemic Baclofen -AMG 487 holds research potential in inflammation and oncology studies
Medchemexpress LLC Apigenin (4',5,7-Trihydroxyflavone) | 520-36-5 | HY-N1201 | 98.9% | 270.24 | 500 MG
Apigenin (4',5,7-Trihydroxyflavone) is identified as a competitive CYP2C9 inhibitor with a Ki of 2 μM. It demonstrates the ability to inhibit cell proliferation, with growth inhibition rates of 38%, 71%, and 99% at concentrations of 20, 40, and 80 μM respectively. The compound also suppresses clone formation in SGC-7901 cells in a dose- and time-dependent manner.
- Competitive inhibitor of Cytochrome P450 2C9 (CYP2C9).
- Exhibits cell proliferation inhibitory activity.
- Suppresses clone formation in specific cell lines.
Apexbio Technology LLC Naringin 10236-47-2 10mM (in 1mL DMSO)
Naringin (CAS 10236-47-2) is a flavanone glycoside predominantly isolated from the fruit of Citrus paradisi Macfadyen (grapefruit) It is recognized for modulating various cellular pathways including inhibition of oxidative stress and inflammation through interaction with NF- B and MAPK signaling cascades Naringin has demonstrated antioxidative anti-inflammatory and potential anti-carcinogenic properties in cellular and animal models Widely used in biomedical research it serves as a tool compound for investigating mechanisms underlying chronic diseases metabolic syndromes and the modulation of drug-metabolizing enzymes For optimal stability it should be stored in a tightly sealed container under cool dry conditions