Flavonoids
Apexbio Technology LLC (±)-AMG 487 10mg
racemic Baclofen -AMG 487 is a small-molecule antagonist targeting the chemokine receptor CXCR3 It is designed to inhibit ligand-induced CXCR3-mediated immune cell migration thereby modulating lymphocyte recruitment to inflammatory and metastatic sites racemic Baclofen -AMG 487 exerts its biological activity primarily through selective inhibition of CXCR3-mediated cell migration In in vitro studies racemic Baclofen -AMG 487 demonstrates inhibition of ligand-induced CXCR3-dependent cell movement Based on these pharmacological properties racemic Baclofen -AMG 487 holds research potential in inflammation and oncology studies
TARGETMOL CHEMICALS INC SAKURANETIN 10MG
Also available in 1 mg 5 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Sakuranetin a flavanone phytoalexin from ultraviolet-irradiated rice leaves it has antifungal antimutagenic anti-inflammatory and antioxidant effectspurity: 99%
Apexbio Technology LLC AST 487 630124-46-8 5mg
AST487 (CAS 630124-46-8) is a small molecule inhibitor primarily targeting RET kinase exhibiting an IC50 of 0 88 M As a member of the N N -diphenylurea class AST487 inhibits RET autophosphorylation and attenuates downstream signaling pathways such as PLC and ERK in a dose-dependent manner It also displays inhibitory activity against additional kinases including KDR Flt-3 and c-Kit In cellular models harboring RET activating mutations (e g C634W) AST487 suppresses RET-mediated signaling and reduces proliferation of thyroid carcinoma cells with RET mutations In xenograft mouse models oral administration of AST487 leads to a notable reduction in tumor volume making it valuable for preclinical studies of RET-driven cancers
Medchemexpress LLC AMG 487 | 473719-41-4 | C32H28F3N5O4 | 100 MG
AMG 487 is an orally active and selective antagonist of CXC chemokine receptor 3 (CXCR3). It inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of 8.0 and 8.2 nM, respectively.
- Targets CXCR3
- Involved in GPCR/G Protein and immunology/inflammation pathways
- Inhibits CXCR3-mediated cell migration
- Inhibits calcium mobilization
- Leads to fewer lung metastases
- Reduces tumor volume
Apexbio Technology LLC FLAVANONE-200MG
Flavanone (CAS No 487-26-3) is a key compound in the study of polyphenols primarily derived from citrus fruits and certain other plants It functions through various biological pathways notably by modulating antioxidant mechanisms influencing enzyme activity and interacting with cellular signaling pathways such as those involving kinases and transcription factors In vitro studies frequently demonstrate its activity in the nanomolar to low micromolar range showcasing its potential in modulating inflammatory responses and oxidative stress Flavanone is widely utilized in cell models to investigate these effects and is also employed in animal studies to explore its pharmacological potential including its efficacy in drug screening applications Experimental concentrations typically depend on the specific research design
Selleck Chemical LLC Flavanone S3679-25mg
Flavanones (2 3-Dihydroflavone 4-Flavanone 2-Phenyl-4-chromanone 2-Phenylchroman-4-one) show strong antioxidant and radical scavenging activity and appear to be associated with a reduced risk of certain chronic diseases the prevention of some cardiovascular disorders and certain kinds of cancer Flavanones also exhibit antiviral antimicrobial and anti-inflammatory activities beneficial effects on capillary fragility and an ability to inhibit human platelet aggregation anti-ulcer and anti-allergenic properties
Apexbio Technology LLC AST 487 630124-46-8 10mg
AST487 (CAS 630124-46-8) is a small molecule inhibitor primarily targeting RET kinase exhibiting an IC50 of 0 88 M As a member of the N N -diphenylurea class AST487 inhibits RET autophosphorylation and attenuates downstream signaling pathways such as PLC and ERK in a dose-dependent manner It also displays inhibitory activity against additional kinases including KDR Flt-3 and c-Kit In cellular models harboring RET activating mutations (e g C634W) AST487 suppresses RET-mediated signaling and reduces proliferation of thyroid carcinoma cells with RET mutations In xenograft mouse models oral administration of AST487 leads to a notable reduction in tumor volume making it valuable for preclinical studies of RET-driven cancers
Medchemexpress LLC 4'-Hydroxyflavanone | 6515-37-3 | 100 MG
4'-Hydroxyflavanone is an inhibitor of SREBP maturation and lipid synthesis. It is a synthetic analogue of flavanone and has potential for research into hepatic steatosis and dyslipidemia.
- Inhibitor of SREBP maturation
- Inhibitor of lipid synthesis
- Synthetic analogue of flavanone
- Potential for hepatic steatosis research
- Potential for dyslipidemia research
- Molecular weight: 240.25
- Formula: C15H12O3
- Appearance: white to light yellow solid
- Purity: 99.75%
- Soluble in DMSO (100 mg/mL)
- Powder storage: -20°C for 3 years, 4°C for 2 years
- In solvent storage: -80°C for 6 months, -20°C for 1 month
Medchemexpress LLC 3'-Hydroxyflavanone | 92496-65-6 | MFCD00017738 | 240.25 g/mol | C15H12O3 | 50 MG
3'-Hydroxyflavanone is a flavanone-class small molecule provided for research use. It is described as a cyclized flavanone with reported apoptosis-inducing activity in HeLa cells and has demonstrated antitumor effects in cell-based studies. Intended for biochemical and cellular research applications; not for human or clinical use.
- Cyclized flavanone scaffold.
- Reported to induce apoptosis in HeLa cells.
- Demonstrates antitumor activity in cell-based studies.
- Suitable for biochemical and cellular research applications.
- Chemical formula C15H12O3; molecular weight 240.25 g/mol.
Medchemexpress LLC 4'-Hydroxyflavanone | 6515-37-3 | 10 MG
This chemical is a synthetic analog of flavanone that functions as an inhibitor of SREBP maturation and lipid synthesis. It holds potential for investigations into hepatic steatosis and dyslipidemia.
- It is an inhibitor of SREBP maturation.
- It inhibits lipid synthesis.
- It is a synthetic analog of flavanone.
- It has potential for research related to hepatic steatosis.
- It has potential for research related to dyslipidemia.
- It is classified as a flavonoid and flavanone.
- It is classified as a phenol and monophenol.
- It is derived from microorganisms, specifically *Aspergillus niger*.