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Reactive Nonmetal Salts

Reactive nonmetal salts are ionic compounds formed with elements classified as reactive nonmetals. These salts are available in a variety of chemical compositions and quantities, and most are formed from the five gaseous reactive nonmetals.

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1

Medchemexpress LLC FD-IN-1 | 1646682-14-5 | 98.6% | 50 MG
SDP

FD-IN-1 is an orally bioavailable and selective factor D (FD) inhibitor with an IC50 of 12 nM, central to the alternative complement pathway of the innate immune system. It also inhibits factor XIa (FXIa) and Tryptase β2 with IC50s of 7.7 and 6.5 μM, respectively. This compound demonstrates systemic suppression of AP activation in vivo and high oral bioavailability in mice (83%) and dogs (70%).

  • Orally bioavailable and selective factor D inhibitor
  • Inhibits factor XIa and Tryptase β2
  • Systemic suppression of AP activation in vivo
  • High oral bioavailability
  • Suitable for research use only

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2

TARGETMOL CHEMICALS INC AEOL-10150 pentachloride 5MG
SDP

Also available in 1 mL, 1 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. AEOL-10150 pentachloride is a metalloporphyrin catalytic antioxidant and superoxide dismutase mimetic that protects lungs from radiation-induced injury.

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3

Medchemexpress LLC 3-chloro-4,7-difluoro-N-[4-(methylamino)cyclohexyl]-N-[(3-pyridin-4-ylphenyl)methyl]-1-benzothiophen | 612542-14-0 | 99.9% | 526.04 | C28H26ClF2N3OS | 50MG
SDP

Hh-Ag1.5 is a potent small-molecule agonist of the Hedgehog signaling pathway (EC50 ≈ 1 nM) for use in in vitro and in vivo pathway activation and stem-cell reprogramming studies. Supplied as a white to off-white solid at high purity, it is formulated for research and preclinical applications.

  • Potency: EC50 1 nM (Hedgehog)
  • CAS number: 612542-14-0
  • Molecular formula: C28H26ClF2N3OS
  • Molecular weight: 526.04
  • Purity: 99.9%
  • Appearance: white to off-white solid
  • Solubility: DMSO 50 mg/mL (use fresh DMSO; ultrasonic may be required)
  • Storage: powder -20°C (3 years), 4°C (2 years)
  • Typical pack sizes: 1 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

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4

Medchemexpress LLC Benzo[b]thiophene-2-carboxamide, 3-chloro-4,7-difluoro-N-[trans-4-(methylamino)cyclohexyl]... | 612542-14-0 | 99.9% | 526.04 | C28H26ClF2N3OS | 100MG
SDP

Hh-Ag1.5 is a potent small-molecule agonist of the Hedgehog signaling pathway that targets Smoothened with an EC50 of about 1 nM. Supplied as a high-purity solid, it is intended for research use in both in vitro and in vivo studies of Hedgehog signaling. The compound exhibits high solubility in DMSO and has defined storage conditions for long-term stability.

  • Potent Hedgehog pathway agonist with EC50 ≈ 1 nM.
  • High purity suitable for analytical and biological assays.
  • Soluble in DMSO at approximately 50 mg/mL for in vitro work.
  • Formulatable for in vivo dosing in common vehicle mixtures.
  • Stable as a powder under frozen storage for extended periods.
  • Available in multiple pack sizes to support screening and scale-up.

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5

Medchemexpress LLC Yangambin | 13060-14-5 | MFCD04307767 | 98.3% | 446.49 | C24H30O8 | 10 MG
SDP

Yangambin is a furofuran lignan supplied for laboratory research that functions as a calcium-channel inhibitor and platelet-activating factor (PAF) receptor antagonist. It reduces intracellular Ca2+ in vascular smooth muscle cells and has reported antiallergic and anti-inflammatory activity in vitro.

  • Acts as a calcium-channel inhibitor and PAF receptor antagonist.
  • Shows antiallergic and anti-inflammatory activity in vitro.
  • High purity (≈98.3%), suitable for biochemical and pharmacological assays.
  • Soluble in DMSO (50 mg/mL) and compatible with several in vivo formulations (≥1.25 mg/mL reported).
  • Furofuran lignan chemical class, C24H30O8, MW 446.49 Da.
  • Store at 4°C protected from light; in solution store at -80°C (6 months) or -20°C (1 month).

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6

Medchemexpress LLC 3-chloro-4,7-difluoro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]-benzo[b]thi | 612542-14-0 | MFCD12032128 | 99.9% | 526.04 | C28H26ClF2N3OS | 25MG
SDP

Hh-Ag1.5 (SAg1.5) is a potent small-molecule agonist of the Hedgehog signaling pathway that activates the Smoothened (Smo) receptor. It is supplied as a white to off-white solid with high reported purity and is used as a research tool to activate Hh signaling in cellular and in vivo studies. The compound is highly soluble in DMSO and has documented storage recommendations for powder and solutions.

  • Potent Hedgehog pathway agonist with EC50 ≈ 1 nM.
  • Activates Smoothened to induce downstream GLI transcription activity.
  • High purity suitable for research (99.9%).
  • Soluble in DMSO at 50 mg/mL; in vivo formulations achievable at ≥2.5 mg/mL.
  • Stable as powder when stored cold; aliquot solutions to avoid freeze-thaw.
  • Demonstrated biological activity in liver stem cell expansion at 5 μM in vitro.

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