N-Bis(2-hydroxypropyl)nitrosamine is a tumor model inducing agent and a metabolite of di-n-propylnitrosamine (DPN). It is used to construct pancreatic cancer models and demonstrates carcinogenic activity. In vivo, it causes tumor development in the lung, liver, and thyroid of rats at a dose of 100 ppm, and in the lung, liver, thyroid, esophagus, kidney, and urinary bladder of rats at a dose of 500 ppm. Bisphenol A (BPA) can enhance the susceptibility to thyroid carcinoma when stimulated by this agent.
- Tumor model inducing agent.
- Metabolite of di-n-propylnitrosamine (DPN).
- Applicable in constructing pancreatic cancer models.
- Demonstrates carcinogenic activity in vitro.
- Induces tumor development in various organs in rats.
- Susceptibility to thyroid carcinoma can be enhanced by Bisphenol A (BPA) stimulation.